Six-Month Outcomes of Goniotomy Performed with the Kahook Dual Blade as a Stand-Alone Glaucoma Procedure

John P. Berdahl, Mark J. Gallardo, Mohammed K. ElMallah, Blake K. Williamson, Malik Y. Kahook, Ahad Mahootchi, Leonard A. Rappaport, Gabriel S. Lazcano-Gomez, Daniela Díaz-Robles, Syril Dorairaj

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction: To characterize the reduction in intraocular pressure (IOP) and IOP-lowering medication use following goniotomy via trabecular meshwork excision performed using the Kahook Dual Blade as a stand-alone procedure in adult eyes with glaucoma uncontrolled on a regimen of 1–3 topical IOP-lowering medications. Methods: In this retrospective analysis, data from consecutive patients undergoing goniotomy with the Kahook Dual Blade by 11 surgeons were analyzed. Preoperative, intraoperative, and postoperative follow-up data through 6 months of follow-up were collected. The primary efficacy endpoint was IOP reduction from preoperative baseline; reduction in IOP-lowering medication use was a secondary endpoint. Results: Data were collected from 53 eyes of 42 subjects. Mean (± SE) preoperative IOP was 23.5 ± 1.1 mmHg, and from day 1 through 6 months of postoperative follow-up mean IOP reductions of 7.0–10.3 mmHg (29.8–43.8%; p < 0.001 at each time point) were observed. Mean preoperative medication use was 2.5 ± 0.2 medications per eye and was reduced by month 6 to 1.5 ± 0.2 (a 40.0% reduction; p < 0.05). Eyes with higher baseline IOP experienced mean IOP reductions of 13.7 mmHg (− 46.4%) at month 6, while eyes with lower baseline IOP experienced mean IOP reductions of 3.8 mmHg (− 21.0%) at month 6. Mean medications were reduced by 1.3 medications in high-IOP eyes and by 0.9 in low-IOP eyes at month 6. No significant sight-threatening adverse events were observed. Conclusions: Goniotomy via trabecular meshwork excision performed using the Kahook Dual Blade effectively and safely lowered IOP when performed as a stand-alone procedure in eyes with glaucoma. The significant drop in IOP met or exceeded the recommended targets for these glaucoma patients. Funding: New World Medical, Inc.

Original languageEnglish (US)
Pages (from-to)2093-2102
Number of pages10
JournalAdvances in Therapy
Volume35
Issue number11
DOIs
StatePublished - Nov 1 2018

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Trabeculectomy
Intraocular Pressure
Glaucoma
Trabecular Meshwork

Keywords

  • Glaucoma
  • Goniotomy
  • Intraocular pressure
  • Micro-incisional glaucoma surgery
  • Minimally invasive glaucoma surgery
  • Ophthalmology

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Berdahl, J. P., Gallardo, M. J., ElMallah, M. K., Williamson, B. K., Kahook, M. Y., Mahootchi, A., ... Dorairaj, S. (2018). Six-Month Outcomes of Goniotomy Performed with the Kahook Dual Blade as a Stand-Alone Glaucoma Procedure. Advances in Therapy, 35(11), 2093-2102. https://doi.org/10.1007/s12325-018-0803-0

Six-Month Outcomes of Goniotomy Performed with the Kahook Dual Blade as a Stand-Alone Glaucoma Procedure. / Berdahl, John P.; Gallardo, Mark J.; ElMallah, Mohammed K.; Williamson, Blake K.; Kahook, Malik Y.; Mahootchi, Ahad; Rappaport, Leonard A.; Lazcano-Gomez, Gabriel S.; Díaz-Robles, Daniela; Dorairaj, Syril.

In: Advances in Therapy, Vol. 35, No. 11, 01.11.2018, p. 2093-2102.

Research output: Contribution to journalArticle

Berdahl, JP, Gallardo, MJ, ElMallah, MK, Williamson, BK, Kahook, MY, Mahootchi, A, Rappaport, LA, Lazcano-Gomez, GS, Díaz-Robles, D & Dorairaj, S 2018, 'Six-Month Outcomes of Goniotomy Performed with the Kahook Dual Blade as a Stand-Alone Glaucoma Procedure', Advances in Therapy, vol. 35, no. 11, pp. 2093-2102. https://doi.org/10.1007/s12325-018-0803-0
Berdahl JP, Gallardo MJ, ElMallah MK, Williamson BK, Kahook MY, Mahootchi A et al. Six-Month Outcomes of Goniotomy Performed with the Kahook Dual Blade as a Stand-Alone Glaucoma Procedure. Advances in Therapy. 2018 Nov 1;35(11):2093-2102. https://doi.org/10.1007/s12325-018-0803-0
Berdahl, John P. ; Gallardo, Mark J. ; ElMallah, Mohammed K. ; Williamson, Blake K. ; Kahook, Malik Y. ; Mahootchi, Ahad ; Rappaport, Leonard A. ; Lazcano-Gomez, Gabriel S. ; Díaz-Robles, Daniela ; Dorairaj, Syril. / Six-Month Outcomes of Goniotomy Performed with the Kahook Dual Blade as a Stand-Alone Glaucoma Procedure. In: Advances in Therapy. 2018 ; Vol. 35, No. 11. pp. 2093-2102.
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abstract = "Introduction: To characterize the reduction in intraocular pressure (IOP) and IOP-lowering medication use following goniotomy via trabecular meshwork excision performed using the Kahook Dual Blade as a stand-alone procedure in adult eyes with glaucoma uncontrolled on a regimen of 1–3 topical IOP-lowering medications. Methods: In this retrospective analysis, data from consecutive patients undergoing goniotomy with the Kahook Dual Blade by 11 surgeons were analyzed. Preoperative, intraoperative, and postoperative follow-up data through 6 months of follow-up were collected. The primary efficacy endpoint was IOP reduction from preoperative baseline; reduction in IOP-lowering medication use was a secondary endpoint. Results: Data were collected from 53 eyes of 42 subjects. Mean (± SE) preoperative IOP was 23.5 ± 1.1 mmHg, and from day 1 through 6 months of postoperative follow-up mean IOP reductions of 7.0–10.3 mmHg (29.8–43.8{\%}; p < 0.001 at each time point) were observed. Mean preoperative medication use was 2.5 ± 0.2 medications per eye and was reduced by month 6 to 1.5 ± 0.2 (a 40.0{\%} reduction; p < 0.05). Eyes with higher baseline IOP experienced mean IOP reductions of 13.7 mmHg (− 46.4{\%}) at month 6, while eyes with lower baseline IOP experienced mean IOP reductions of 3.8 mmHg (− 21.0{\%}) at month 6. Mean medications were reduced by 1.3 medications in high-IOP eyes and by 0.9 in low-IOP eyes at month 6. No significant sight-threatening adverse events were observed. Conclusions: Goniotomy via trabecular meshwork excision performed using the Kahook Dual Blade effectively and safely lowered IOP when performed as a stand-alone procedure in eyes with glaucoma. The significant drop in IOP met or exceeded the recommended targets for these glaucoma patients. Funding: New World Medical, Inc.",
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T1 - Six-Month Outcomes of Goniotomy Performed with the Kahook Dual Blade as a Stand-Alone Glaucoma Procedure

AU - Berdahl, John P.

AU - Gallardo, Mark J.

AU - ElMallah, Mohammed K.

AU - Williamson, Blake K.

AU - Kahook, Malik Y.

AU - Mahootchi, Ahad

AU - Rappaport, Leonard A.

AU - Lazcano-Gomez, Gabriel S.

AU - Díaz-Robles, Daniela

AU - Dorairaj, Syril

PY - 2018/11/1

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N2 - Introduction: To characterize the reduction in intraocular pressure (IOP) and IOP-lowering medication use following goniotomy via trabecular meshwork excision performed using the Kahook Dual Blade as a stand-alone procedure in adult eyes with glaucoma uncontrolled on a regimen of 1–3 topical IOP-lowering medications. Methods: In this retrospective analysis, data from consecutive patients undergoing goniotomy with the Kahook Dual Blade by 11 surgeons were analyzed. Preoperative, intraoperative, and postoperative follow-up data through 6 months of follow-up were collected. The primary efficacy endpoint was IOP reduction from preoperative baseline; reduction in IOP-lowering medication use was a secondary endpoint. Results: Data were collected from 53 eyes of 42 subjects. Mean (± SE) preoperative IOP was 23.5 ± 1.1 mmHg, and from day 1 through 6 months of postoperative follow-up mean IOP reductions of 7.0–10.3 mmHg (29.8–43.8%; p < 0.001 at each time point) were observed. Mean preoperative medication use was 2.5 ± 0.2 medications per eye and was reduced by month 6 to 1.5 ± 0.2 (a 40.0% reduction; p < 0.05). Eyes with higher baseline IOP experienced mean IOP reductions of 13.7 mmHg (− 46.4%) at month 6, while eyes with lower baseline IOP experienced mean IOP reductions of 3.8 mmHg (− 21.0%) at month 6. Mean medications were reduced by 1.3 medications in high-IOP eyes and by 0.9 in low-IOP eyes at month 6. No significant sight-threatening adverse events were observed. Conclusions: Goniotomy via trabecular meshwork excision performed using the Kahook Dual Blade effectively and safely lowered IOP when performed as a stand-alone procedure in eyes with glaucoma. The significant drop in IOP met or exceeded the recommended targets for these glaucoma patients. Funding: New World Medical, Inc.

AB - Introduction: To characterize the reduction in intraocular pressure (IOP) and IOP-lowering medication use following goniotomy via trabecular meshwork excision performed using the Kahook Dual Blade as a stand-alone procedure in adult eyes with glaucoma uncontrolled on a regimen of 1–3 topical IOP-lowering medications. Methods: In this retrospective analysis, data from consecutive patients undergoing goniotomy with the Kahook Dual Blade by 11 surgeons were analyzed. Preoperative, intraoperative, and postoperative follow-up data through 6 months of follow-up were collected. The primary efficacy endpoint was IOP reduction from preoperative baseline; reduction in IOP-lowering medication use was a secondary endpoint. Results: Data were collected from 53 eyes of 42 subjects. Mean (± SE) preoperative IOP was 23.5 ± 1.1 mmHg, and from day 1 through 6 months of postoperative follow-up mean IOP reductions of 7.0–10.3 mmHg (29.8–43.8%; p < 0.001 at each time point) were observed. Mean preoperative medication use was 2.5 ± 0.2 medications per eye and was reduced by month 6 to 1.5 ± 0.2 (a 40.0% reduction; p < 0.05). Eyes with higher baseline IOP experienced mean IOP reductions of 13.7 mmHg (− 46.4%) at month 6, while eyes with lower baseline IOP experienced mean IOP reductions of 3.8 mmHg (− 21.0%) at month 6. Mean medications were reduced by 1.3 medications in high-IOP eyes and by 0.9 in low-IOP eyes at month 6. No significant sight-threatening adverse events were observed. Conclusions: Goniotomy via trabecular meshwork excision performed using the Kahook Dual Blade effectively and safely lowered IOP when performed as a stand-alone procedure in eyes with glaucoma. The significant drop in IOP met or exceeded the recommended targets for these glaucoma patients. Funding: New World Medical, Inc.

KW - Glaucoma

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KW - Intraocular pressure

KW - Micro-incisional glaucoma surgery

KW - Minimally invasive glaucoma surgery

KW - Ophthalmology

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