Sinusoidal communication in liver fibrosis and regeneration

Giusi Marrone, Vijay Shah, Jordi Gracia-Sancho

Research output: Contribution to journalReview article

69 Scopus citations

Abstract

Cellular crosstalk is a process through which a message is transmitted within an individual cell (intracellular crosstalk) or between different cells (intercellular crosstalk). Intercellular crosstalk within the liver microenvironment is critical for the maintenance of normal hepatic functions and for cells survival. Hepatic cells are closely connected to each other, work in synergy, and produce molecules that modulate their differentiation and activity. This review summarises the current knowledge regarding paracrine communication networks in parenchymal and non-parenchymal cells in liver fibrosis due to chronic injury, and regeneration after partial hepatectomy.

Original languageEnglish (US)
Pages (from-to)608-617
Number of pages10
JournalJournal of Hepatology
Volume65
Issue number3
DOIs
StatePublished - Sep 1 2016

Keywords

  • Cirrhosis
  • Hepatic stellate cells
  • Hepatocytes
  • HSC
  • Ischemia/reperfusion
  • Kupffer cells
  • Liver sinusoidal endothelial cells
  • LSEC
  • Portal hypertension
  • Regeneration
  • Transplantation

ASJC Scopus subject areas

  • Hepatology

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