Sinusoidal communication in liver fibrosis and regeneration

Giusi Marrone; Vijay H. Shah; Jordi Gracia-Sancho

doi:10.1016/j.jhep.2016.04.018

Sinusoidal communication in liver fibrosis and regeneration

Giusi Marrone, Vijay H. Shah, Jordi Gracia-Sancho

Gastroenterology and Hepatology

Research output: Contribution to journal › Review article › peer-review

97 Scopus citations

Abstract

Cellular crosstalk is a process through which a message is transmitted within an individual cell (intracellular crosstalk) or between different cells (intercellular crosstalk). Intercellular crosstalk within the liver microenvironment is critical for the maintenance of normal hepatic functions and for cells survival. Hepatic cells are closely connected to each other, work in synergy, and produce molecules that modulate their differentiation and activity. This review summarises the current knowledge regarding paracrine communication networks in parenchymal and non-parenchymal cells in liver fibrosis due to chronic injury, and regeneration after partial hepatectomy.

Original language	English (US)
Pages (from-to)	608-617
Number of pages	10
Journal	Journal of hepatology
Volume	65
Issue number	3
DOIs	https://doi.org/10.1016/j.jhep.2016.04.018
State	Published - Sep 1 2016

Keywords

Cirrhosis
HSC
Hepatic stellate cells
Hepatocytes
Ischemia/reperfusion
Kupffer cells
LSEC
Liver sinusoidal endothelial cells
Portal hypertension
Regeneration
Transplantation

ASJC Scopus subject areas

Hepatology

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10.1016/j.jhep.2016.04.018

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title = "Sinusoidal communication in liver fibrosis and regeneration",

abstract = "Cellular crosstalk is a process through which a message is transmitted within an individual cell (intracellular crosstalk) or between different cells (intercellular crosstalk). Intercellular crosstalk within the liver microenvironment is critical for the maintenance of normal hepatic functions and for cells survival. Hepatic cells are closely connected to each other, work in synergy, and produce molecules that modulate their differentiation and activity. This review summarises the current knowledge regarding paracrine communication networks in parenchymal and non-parenchymal cells in liver fibrosis due to chronic injury, and regeneration after partial hepatectomy.",

keywords = "Cirrhosis, HSC, Hepatic stellate cells, Hepatocytes, Ischemia/reperfusion, Kupffer cells, LSEC, Liver sinusoidal endothelial cells, Portal hypertension, Regeneration, Transplantation",

author = "Giusi Marrone and Shah, {Vijay H.} and Jordi Gracia-Sancho",

note = "Publisher Copyright: {\textcopyright} 2016 European Association for the Study of the Liver",

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T1 - Sinusoidal communication in liver fibrosis and regeneration

AU - Marrone, Giusi

AU - Shah, Vijay H.

AU - Gracia-Sancho, Jordi

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Cellular crosstalk is a process through which a message is transmitted within an individual cell (intracellular crosstalk) or between different cells (intercellular crosstalk). Intercellular crosstalk within the liver microenvironment is critical for the maintenance of normal hepatic functions and for cells survival. Hepatic cells are closely connected to each other, work in synergy, and produce molecules that modulate their differentiation and activity. This review summarises the current knowledge regarding paracrine communication networks in parenchymal and non-parenchymal cells in liver fibrosis due to chronic injury, and regeneration after partial hepatectomy.

AB - Cellular crosstalk is a process through which a message is transmitted within an individual cell (intracellular crosstalk) or between different cells (intercellular crosstalk). Intercellular crosstalk within the liver microenvironment is critical for the maintenance of normal hepatic functions and for cells survival. Hepatic cells are closely connected to each other, work in synergy, and produce molecules that modulate their differentiation and activity. This review summarises the current knowledge regarding paracrine communication networks in parenchymal and non-parenchymal cells in liver fibrosis due to chronic injury, and regeneration after partial hepatectomy.

KW - Cirrhosis

KW - HSC

KW - Hepatic stellate cells

KW - Hepatocytes

KW - Ischemia/reperfusion

KW - Kupffer cells

KW - LSEC

KW - Liver sinusoidal endothelial cells

KW - Portal hypertension

KW - Regeneration

KW - Transplantation

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DO - 10.1016/j.jhep.2016.04.018

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JO - Journal of hepatology

JF - Journal of hepatology

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Sinusoidal communication in liver fibrosis and regeneration

Abstract

Keywords

ASJC Scopus subject areas

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