Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines

Inna G. Ovsyannikova, Hannah M. Salk, Beth R. Larrabee, V. Shane Pankratz, Gregory A. Poland

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Single-nucleotide polymorphisms (SNPs) in candidate immune response genes were evaluated for associations with measles- and rubella-specific neutralizing antibodies, interferon (IFN)-γ, and interleukin (IL)-6 secretion in two separate association analyses in a cohort of healthy immunized subjects. We identified six SNP associations shared between the measles-specific and rubella-specific immune responses, specifically neutralizing antibody titers (DDX58), secreted IL-6 (IL10RB, IL12B), and secreted IFN-γ (IFNAR2, TLR4). An intronic SNP (rs669260) in the antiviral innate immune receptor gene, DDX58, was significantly associated with increased neutralizing antibody titers for both measles and rubella viral antigens post-MMR vaccination (p values 0.02 and 0.0002, respectively). Significant associations were also found between IL10RB (rs2284552; measles study p value 0.006, rubella study p value 0.00008) and IL12B (rs2546893; measles study p value 0.005, rubella study p value 0.03) gene polymorphisms and variations in both measles- and rubella virus-specific IL-6 responses. We also identified associations between individual SNPs in the IFNAR2 and TLR4 genes that were associated with IFN-γ secretion for both measles and rubella vaccine-specific immune responses. These results are the first to indicate that there are SNP associations in common across measles and rubella vaccine immune responses and that SNPs from multiple genes involved in innate and adaptive immune response regulation may contribute to the overall human antiviral response.

Original languageEnglish (US)
Pages (from-to)663-669
Number of pages7
JournalImmunogenetics
Volume66
Issue number11
DOIs
StatePublished - Nov 1 2014

Fingerprint

Rubella Vaccine
Measles Vaccine
Rubella
Measles
Single Nucleotide Polymorphism
Neutralizing Antibodies
Interferons
Interleukin-6
Genes
Antiviral Agents
Rubella virus
Measles virus
Viral Antigens
Adaptive Immunity
Innate Immunity
Healthy Volunteers
Vaccination

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ovsyannikova, I. G., Salk, H. M., Larrabee, B. R., Pankratz, V. S., & Poland, G. A. (2014). Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines. Immunogenetics, 66(11), 663-669. https://doi.org/10.1007/s00251-014-0796-z

Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines. / Ovsyannikova, Inna G.; Salk, Hannah M.; Larrabee, Beth R.; Pankratz, V. Shane; Poland, Gregory A.

In: Immunogenetics, Vol. 66, No. 11, 01.11.2014, p. 663-669.

Research output: Contribution to journalArticle

Ovsyannikova, IG, Salk, HM, Larrabee, BR, Pankratz, VS & Poland, GA 2014, 'Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines', Immunogenetics, vol. 66, no. 11, pp. 663-669. https://doi.org/10.1007/s00251-014-0796-z
Ovsyannikova, Inna G. ; Salk, Hannah M. ; Larrabee, Beth R. ; Pankratz, V. Shane ; Poland, Gregory A. / Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines. In: Immunogenetics. 2014 ; Vol. 66, No. 11. pp. 663-669.
@article{4d87a451e2394a44ad290f2df6f2cc0f,
title = "Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines",
abstract = "Single-nucleotide polymorphisms (SNPs) in candidate immune response genes were evaluated for associations with measles- and rubella-specific neutralizing antibodies, interferon (IFN)-γ, and interleukin (IL)-6 secretion in two separate association analyses in a cohort of healthy immunized subjects. We identified six SNP associations shared between the measles-specific and rubella-specific immune responses, specifically neutralizing antibody titers (DDX58), secreted IL-6 (IL10RB, IL12B), and secreted IFN-γ (IFNAR2, TLR4). An intronic SNP (rs669260) in the antiviral innate immune receptor gene, DDX58, was significantly associated with increased neutralizing antibody titers for both measles and rubella viral antigens post-MMR vaccination (p values 0.02 and 0.0002, respectively). Significant associations were also found between IL10RB (rs2284552; measles study p value 0.006, rubella study p value 0.00008) and IL12B (rs2546893; measles study p value 0.005, rubella study p value 0.03) gene polymorphisms and variations in both measles- and rubella virus-specific IL-6 responses. We also identified associations between individual SNPs in the IFNAR2 and TLR4 genes that were associated with IFN-γ secretion for both measles and rubella vaccine-specific immune responses. These results are the first to indicate that there are SNP associations in common across measles and rubella vaccine immune responses and that SNPs from multiple genes involved in innate and adaptive immune response regulation may contribute to the overall human antiviral response.",
author = "Ovsyannikova, {Inna G.} and Salk, {Hannah M.} and Larrabee, {Beth R.} and Pankratz, {V. Shane} and Poland, {Gregory A.}",
year = "2014",
month = "11",
day = "1",
doi = "10.1007/s00251-014-0796-z",
language = "English (US)",
volume = "66",
pages = "663--669",
journal = "Immunogenetics",
issn = "0093-7711",
publisher = "Springer Verlag",
number = "11",

}

TY - JOUR

T1 - Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines

AU - Ovsyannikova, Inna G.

AU - Salk, Hannah M.

AU - Larrabee, Beth R.

AU - Pankratz, V. Shane

AU - Poland, Gregory A.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Single-nucleotide polymorphisms (SNPs) in candidate immune response genes were evaluated for associations with measles- and rubella-specific neutralizing antibodies, interferon (IFN)-γ, and interleukin (IL)-6 secretion in two separate association analyses in a cohort of healthy immunized subjects. We identified six SNP associations shared between the measles-specific and rubella-specific immune responses, specifically neutralizing antibody titers (DDX58), secreted IL-6 (IL10RB, IL12B), and secreted IFN-γ (IFNAR2, TLR4). An intronic SNP (rs669260) in the antiviral innate immune receptor gene, DDX58, was significantly associated with increased neutralizing antibody titers for both measles and rubella viral antigens post-MMR vaccination (p values 0.02 and 0.0002, respectively). Significant associations were also found between IL10RB (rs2284552; measles study p value 0.006, rubella study p value 0.00008) and IL12B (rs2546893; measles study p value 0.005, rubella study p value 0.03) gene polymorphisms and variations in both measles- and rubella virus-specific IL-6 responses. We also identified associations between individual SNPs in the IFNAR2 and TLR4 genes that were associated with IFN-γ secretion for both measles and rubella vaccine-specific immune responses. These results are the first to indicate that there are SNP associations in common across measles and rubella vaccine immune responses and that SNPs from multiple genes involved in innate and adaptive immune response regulation may contribute to the overall human antiviral response.

AB - Single-nucleotide polymorphisms (SNPs) in candidate immune response genes were evaluated for associations with measles- and rubella-specific neutralizing antibodies, interferon (IFN)-γ, and interleukin (IL)-6 secretion in two separate association analyses in a cohort of healthy immunized subjects. We identified six SNP associations shared between the measles-specific and rubella-specific immune responses, specifically neutralizing antibody titers (DDX58), secreted IL-6 (IL10RB, IL12B), and secreted IFN-γ (IFNAR2, TLR4). An intronic SNP (rs669260) in the antiviral innate immune receptor gene, DDX58, was significantly associated with increased neutralizing antibody titers for both measles and rubella viral antigens post-MMR vaccination (p values 0.02 and 0.0002, respectively). Significant associations were also found between IL10RB (rs2284552; measles study p value 0.006, rubella study p value 0.00008) and IL12B (rs2546893; measles study p value 0.005, rubella study p value 0.03) gene polymorphisms and variations in both measles- and rubella virus-specific IL-6 responses. We also identified associations between individual SNPs in the IFNAR2 and TLR4 genes that were associated with IFN-γ secretion for both measles and rubella vaccine-specific immune responses. These results are the first to indicate that there are SNP associations in common across measles and rubella vaccine immune responses and that SNPs from multiple genes involved in innate and adaptive immune response regulation may contribute to the overall human antiviral response.

UR - http://www.scopus.com/inward/record.url?scp=84921973951&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921973951&partnerID=8YFLogxK

U2 - 10.1007/s00251-014-0796-z

DO - 10.1007/s00251-014-0796-z

M3 - Article

VL - 66

SP - 663

EP - 669

JO - Immunogenetics

JF - Immunogenetics

SN - 0093-7711

IS - 11

ER -