TY - JOUR
T1 - Simultaneous epicardial and endocardial substrate mapping and radiofrequency catheter ablation as first-line treatment for ventricular tachycardia and frequent ICD shocks in chronic chagasic cardiomyopathy
AU - Henz, Benhur Davi
AU - Do Nascimento, Thais A.
AU - Dietrich, Cristiano De O.
AU - Dalegrave, Charles
AU - Hernandes, Veruska
AU - Mesas, Cezar E.
AU - Leite, Luiz R.
AU - Cirenza, Claudio
AU - Asirvatham, Samuel J.
AU - De Paola, Angelo Amato Vincenzo
N1 - Funding Information:
This study was in part supported by Biosense
Funding Information:
Dr. Henz is the recipient of a research grant from the CAPES, a Brazilian government research institute. B.D.Henz.T.A.doNascimento.C.d.Dietrich.C.Dalegrave. V. Hernandes.C. E. Mesas.L. R. Leite.C. Cirenza. A. A. V. de Paola (*) Clinical Cardiac Electrophysiology, Cardiology Division Hospital São Paulo, Paulista School of Medicine, Federal University of São Paulo, Rua Napoleao de Barros 715 - São Paulo, 04024-002 São Paulo, Brazil e-mail: depaola@uol.com.br
PY - 2009/12
Y1 - 2009/12
N2 - Background and Aims: Slow conduction scarred areas are related with ventricular tachycardia (VT) arrhythmogenesis in nonischemic cardiomyopathy. The purpose of this study was to characterize the substrate in both epicardial and endocardial surfaces of the left ventricle and to evaluate the effectiveness of substrate mapping and ablation for VT in Chagas cardiomyopathy. Methods and Results: Seventeen patients were evaluated prospectively using a simultaneous epicardial and endocardial electroanatomical substrate mapping and ablation. With a mean of 201 ± 94 epicardial and 169 ± 77 endocardial points, the epicardial voltage areas ≤0.5 mV were 56.8 ± 40.6 (range 4.4 to 154.8 cm2) as compared to 22.5 ± 15.8 cm2 (range 5.4 to 61.0 cm2; p = 0.004) in the endocardium. Analyzing the epicardial surface, there was a strong correlation between the bipolar voltage electrograms and the electrogram duration at the epicardium during sinus rhythm (r = 0.897, p < 0.0001). Acute success was obtained in 83.3% of patients with no serious complications. At the end of follow-up from 14 patients with acute success, 11 (78.6%) had been event-free based on implantable cardioverter defibrillator (ICD) interrogation logs. Conclusion: Chronic Chagas cardiomyopathy patients have larger epicardial as compared to endocardial substrate areas. Combined epicardial endocardial substrate mapping and ablation during sinus rhythm proves effective in preventing VT recurrences and appropriate ICD therapies.
AB - Background and Aims: Slow conduction scarred areas are related with ventricular tachycardia (VT) arrhythmogenesis in nonischemic cardiomyopathy. The purpose of this study was to characterize the substrate in both epicardial and endocardial surfaces of the left ventricle and to evaluate the effectiveness of substrate mapping and ablation for VT in Chagas cardiomyopathy. Methods and Results: Seventeen patients were evaluated prospectively using a simultaneous epicardial and endocardial electroanatomical substrate mapping and ablation. With a mean of 201 ± 94 epicardial and 169 ± 77 endocardial points, the epicardial voltage areas ≤0.5 mV were 56.8 ± 40.6 (range 4.4 to 154.8 cm2) as compared to 22.5 ± 15.8 cm2 (range 5.4 to 61.0 cm2; p = 0.004) in the endocardium. Analyzing the epicardial surface, there was a strong correlation between the bipolar voltage electrograms and the electrogram duration at the epicardium during sinus rhythm (r = 0.897, p < 0.0001). Acute success was obtained in 83.3% of patients with no serious complications. At the end of follow-up from 14 patients with acute success, 11 (78.6%) had been event-free based on implantable cardioverter defibrillator (ICD) interrogation logs. Conclusion: Chronic Chagas cardiomyopathy patients have larger epicardial as compared to endocardial substrate areas. Combined epicardial endocardial substrate mapping and ablation during sinus rhythm proves effective in preventing VT recurrences and appropriate ICD therapies.
KW - Catheter ablation
KW - Chagas cardiomyopathy
KW - Epicardial
KW - Substrate mapping
KW - Ventricular tachycardia
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U2 - 10.1007/s10840-009-9433-4
DO - 10.1007/s10840-009-9433-4
M3 - Article
C2 - 19757003
AN - SCOPUS:75949118698
SN - 1383-875X
VL - 26
SP - 195
EP - 205
JO - Journal of Interventional Cardiac Electrophysiology
JF - Journal of Interventional Cardiac Electrophysiology
IS - 3
ER -