Simulation of the vertical gradient of transpulmonary pressure by stable foams

D. O. Warner, K. Rehder, R. E. Hyatt

Research output: Contribution to journalArticle

Abstract

We describe a simulation of the vertical gradient of transpulmonary pressure (VGTP) using a stable foam, which is suitable for use in studies of the effect of the VGTP on excised lungs. We generated foams that produced linear hydrostatic pressure gradients (HPGs) from 0.18 to 0.44 cmH2O/cm depth, which were stable over time and were reproducible. The HPG was similar under static and dynamic conditions. The foam did not affect lung elastic properties or cause histological changes. We conclude that these stable foams provide a practical, inexpensive simulation of the VGTP and should be useful in studying the effects of the VGTP on regional lung behavior.

Original languageEnglish (US)
Pages (from-to)1221-1225
Number of pages5
JournalJournal of applied physiology
Volume61
Issue number3
DOIs
StatePublished - 1986

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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