Should all patients with pulmonary hypertension undergo HIV serologic testing?

Alexis A. Vazquez, Javier F. Aduen, Paula Aduen, Michael G. Heckman, Charles Dwayne Burger

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

OBJECTIVES: To evaluate the yield of screening patients with pulmonary hypertension (PH) for human immunodeficiency virus (HIV) infection. METHODS: We retrospectively reviewed the records of consecutive patients with PH seen at our institution from July 1992 to November 2008. We assessed HIV risk factors and history of HIV. We estimated the proportion of patients who tested positive for HIV. RESULTS: We identified 445 patients with PH who had serologic testing for HIV antibody. The mean age was 63 years, and 66% were women. Of these patients, 224 (50%) were in World Health Organization diagnostic group I, pulmonary arterial hypertension (PAH). Only 1 patient (0.2%; 95% confidence interval, 0.0%-1.2%) was positive for HIV, and this was the only patient who had a known history of HIV infection. Ten other patients (2.2%) had risk factors for HIV infection but had negative serologic results. The patient who tested positive for HIV had PAH, yielding an estimated prevalence of positive HIV testing in that subgroup of 0.4% (95% confidence interval, 0.0%-2.5%); 6 other patients with PAH (2.7%) had risk factors for HIV but negative serology. CONCLUSIONS: To our knowledge, this is the first study examining the yield of screening patients with PH for HIV using serologic testing. Of the 445 patients tested, only 1 patient was positive for HIV. This patient was known to have risk factors for and exposure to HIV. Patients with PAH should be assessed for risk factors for HIV before testing for HIV in low-risk populations.

Original languageEnglish (US)
Pages (from-to)589-592
Number of pages4
JournalSouthern Medical Journal
Volume104
Issue number8
DOIs
StatePublished - Aug 2011

Fingerprint

Pulmonary Hypertension
HIV
Virus Diseases
Confidence Intervals
Serology

Keywords

  • HIV
  • HIV screening
  • human immunodeficiency virus
  • pulmonary hypertension

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Should all patients with pulmonary hypertension undergo HIV serologic testing? / Vazquez, Alexis A.; Aduen, Javier F.; Aduen, Paula; Heckman, Michael G.; Burger, Charles Dwayne.

In: Southern Medical Journal, Vol. 104, No. 8, 08.2011, p. 589-592.

Research output: Contribution to journalArticle

Vazquez, Alexis A. ; Aduen, Javier F. ; Aduen, Paula ; Heckman, Michael G. ; Burger, Charles Dwayne. / Should all patients with pulmonary hypertension undergo HIV serologic testing?. In: Southern Medical Journal. 2011 ; Vol. 104, No. 8. pp. 589-592.
@article{a1dc454f64c84ef4b73b4640c2c342ec,
title = "Should all patients with pulmonary hypertension undergo HIV serologic testing?",
abstract = "OBJECTIVES: To evaluate the yield of screening patients with pulmonary hypertension (PH) for human immunodeficiency virus (HIV) infection. METHODS: We retrospectively reviewed the records of consecutive patients with PH seen at our institution from July 1992 to November 2008. We assessed HIV risk factors and history of HIV. We estimated the proportion of patients who tested positive for HIV. RESULTS: We identified 445 patients with PH who had serologic testing for HIV antibody. The mean age was 63 years, and 66{\%} were women. Of these patients, 224 (50{\%}) were in World Health Organization diagnostic group I, pulmonary arterial hypertension (PAH). Only 1 patient (0.2{\%}; 95{\%} confidence interval, 0.0{\%}-1.2{\%}) was positive for HIV, and this was the only patient who had a known history of HIV infection. Ten other patients (2.2{\%}) had risk factors for HIV infection but had negative serologic results. The patient who tested positive for HIV had PAH, yielding an estimated prevalence of positive HIV testing in that subgroup of 0.4{\%} (95{\%} confidence interval, 0.0{\%}-2.5{\%}); 6 other patients with PAH (2.7{\%}) had risk factors for HIV but negative serology. CONCLUSIONS: To our knowledge, this is the first study examining the yield of screening patients with PH for HIV using serologic testing. Of the 445 patients tested, only 1 patient was positive for HIV. This patient was known to have risk factors for and exposure to HIV. Patients with PAH should be assessed for risk factors for HIV before testing for HIV in low-risk populations.",
keywords = "HIV, HIV screening, human immunodeficiency virus, pulmonary hypertension",
author = "Vazquez, {Alexis A.} and Aduen, {Javier F.} and Paula Aduen and Heckman, {Michael G.} and Burger, {Charles Dwayne}",
year = "2011",
month = "8",
doi = "10.1097/SMJ.0b013e318225cdfd",
language = "English (US)",
volume = "104",
pages = "589--592",
journal = "Southern Medical Journal",
issn = "0038-4348",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Should all patients with pulmonary hypertension undergo HIV serologic testing?

AU - Vazquez, Alexis A.

AU - Aduen, Javier F.

AU - Aduen, Paula

AU - Heckman, Michael G.

AU - Burger, Charles Dwayne

PY - 2011/8

Y1 - 2011/8

N2 - OBJECTIVES: To evaluate the yield of screening patients with pulmonary hypertension (PH) for human immunodeficiency virus (HIV) infection. METHODS: We retrospectively reviewed the records of consecutive patients with PH seen at our institution from July 1992 to November 2008. We assessed HIV risk factors and history of HIV. We estimated the proportion of patients who tested positive for HIV. RESULTS: We identified 445 patients with PH who had serologic testing for HIV antibody. The mean age was 63 years, and 66% were women. Of these patients, 224 (50%) were in World Health Organization diagnostic group I, pulmonary arterial hypertension (PAH). Only 1 patient (0.2%; 95% confidence interval, 0.0%-1.2%) was positive for HIV, and this was the only patient who had a known history of HIV infection. Ten other patients (2.2%) had risk factors for HIV infection but had negative serologic results. The patient who tested positive for HIV had PAH, yielding an estimated prevalence of positive HIV testing in that subgroup of 0.4% (95% confidence interval, 0.0%-2.5%); 6 other patients with PAH (2.7%) had risk factors for HIV but negative serology. CONCLUSIONS: To our knowledge, this is the first study examining the yield of screening patients with PH for HIV using serologic testing. Of the 445 patients tested, only 1 patient was positive for HIV. This patient was known to have risk factors for and exposure to HIV. Patients with PAH should be assessed for risk factors for HIV before testing for HIV in low-risk populations.

AB - OBJECTIVES: To evaluate the yield of screening patients with pulmonary hypertension (PH) for human immunodeficiency virus (HIV) infection. METHODS: We retrospectively reviewed the records of consecutive patients with PH seen at our institution from July 1992 to November 2008. We assessed HIV risk factors and history of HIV. We estimated the proportion of patients who tested positive for HIV. RESULTS: We identified 445 patients with PH who had serologic testing for HIV antibody. The mean age was 63 years, and 66% were women. Of these patients, 224 (50%) were in World Health Organization diagnostic group I, pulmonary arterial hypertension (PAH). Only 1 patient (0.2%; 95% confidence interval, 0.0%-1.2%) was positive for HIV, and this was the only patient who had a known history of HIV infection. Ten other patients (2.2%) had risk factors for HIV infection but had negative serologic results. The patient who tested positive for HIV had PAH, yielding an estimated prevalence of positive HIV testing in that subgroup of 0.4% (95% confidence interval, 0.0%-2.5%); 6 other patients with PAH (2.7%) had risk factors for HIV but negative serology. CONCLUSIONS: To our knowledge, this is the first study examining the yield of screening patients with PH for HIV using serologic testing. Of the 445 patients tested, only 1 patient was positive for HIV. This patient was known to have risk factors for and exposure to HIV. Patients with PAH should be assessed for risk factors for HIV before testing for HIV in low-risk populations.

KW - HIV

KW - HIV screening

KW - human immunodeficiency virus

KW - pulmonary hypertension

UR - http://www.scopus.com/inward/record.url?scp=80051528120&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80051528120&partnerID=8YFLogxK

U2 - 10.1097/SMJ.0b013e318225cdfd

DO - 10.1097/SMJ.0b013e318225cdfd

M3 - Article

C2 - 21886069

AN - SCOPUS:80051528120

VL - 104

SP - 589

EP - 592

JO - Southern Medical Journal

JF - Southern Medical Journal

SN - 0038-4348

IS - 8

ER -