Short and long telomeres increase risk of amnestic mild cognitive impairment

Rosebud O Roberts, Lisa Allyn Boardman, Ruth H. Cha, V. Shane Pankratz, Ruth A. Johnson, Brooke R. Druliner, Teresa J H Christianson, Lewis Rowland Roberts, Ronald Carl Petersen

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Peripheral blood telomere length has been associated with age-related conditions including Alzheimer's disease (AD). This suggests that telomere length may identify subjects at increased risk of AD. Thus, we investigated the associations of peripheral blood telomere length with amnestic mild cognitive impairment (aMCI), a putative precursor of AD, among Mayo Clinic Study of Aging participants who were prospectively followed for incident aMCI. We matched 137 incident aMCI cases (mean age 81.1 years, [range 70.9-90.8]; 49.6% men) by age and sex to 137 cognitively normal controls. We measured telomere length (T/S ratio) at baseline using quantitative PCR. Compared to the middle T/S quintile (Q3), the risk of aMCI was elevated for subjects with the shortest (Q1: HR, 2.85, 95% Confidence interval [CI] 0.98, 8.25; p= 0.05) and the longest telomere lengths (Q5: HR, 5.58, 95%CI, 2.21, 14.11; p= 0.0003). In this elderly cohort, short and long telomeres were associated with increased risk of aMCI. Our findings suggest that both long and short telomere lengths may play a role in the pathogenesis of aMCI, and may be markers of increased risk of aMCI.

Original languageEnglish (US)
Pages (from-to)64-69
Number of pages6
JournalMechanisms of Ageing and Development
Volume141-142
DOIs
StatePublished - Nov 1 2014

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Telomere
Alzheimer Disease
Confidence Intervals
Cognitive Dysfunction
Polymerase Chain Reaction

Keywords

  • Aging cells
  • Alzheimer disease
  • Cohort study
  • Leukocyte telomere length
  • Mild cognitive impairment
  • Population-based

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

Cite this

Short and long telomeres increase risk of amnestic mild cognitive impairment. / Roberts, Rosebud O; Boardman, Lisa Allyn; Cha, Ruth H.; Pankratz, V. Shane; Johnson, Ruth A.; Druliner, Brooke R.; Christianson, Teresa J H; Roberts, Lewis Rowland; Petersen, Ronald Carl.

In: Mechanisms of Ageing and Development, Vol. 141-142, 01.11.2014, p. 64-69.

Research output: Contribution to journalArticle

Roberts, Rosebud O ; Boardman, Lisa Allyn ; Cha, Ruth H. ; Pankratz, V. Shane ; Johnson, Ruth A. ; Druliner, Brooke R. ; Christianson, Teresa J H ; Roberts, Lewis Rowland ; Petersen, Ronald Carl. / Short and long telomeres increase risk of amnestic mild cognitive impairment. In: Mechanisms of Ageing and Development. 2014 ; Vol. 141-142. pp. 64-69.
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