Sex-specific association of lipoprotein(a) with presence and quantity of coronary artery calcification in an asymptomatic population

Andrea E. Cassidy, Lawrence F. Bielak, Iftikhar Jan Kullo, George G. Klee, Stephen T Turner, Patrick F. Sheedy, Patricia A. Peyser

Research output: Contribution to journalArticle

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Abstract

Background: Lipoprotein(a) (Lp(a)) is a potential risk factor for coronary artery disease (CAD). The relationship between serum Lp (a) and coronary artery calcification (CAC), a measure of subclinical coronary artery atherosclerosis, has not been extensively explored. Material/Methods: Electron beam computed tomography was performed on 616 asymptomatic, white individuals (285 men) from a community-based study. Mean age was 57.2 years. Serum Lp (a) levels were measured by an immunoturbidimetric assay. Tobit regression was used to determine the sex-specific association of Lp (a) levels with presence and quantity of CAC. Results: In women, Lp (a) was a significant predictor (P=0.0426) of presence and quantity of CAC after adjustment for age, hypertension status, waist circumference, presence of high low-density lipoprotein cholesterol (LDL-C), and history of smoking. In men, after adjusting for age, hypertension status, body mass index, presence of high LDL-C, and history of smoking, a positive interaction between Lp (a) and history of smoking (P=0.0387) was significantly associated with presence and quantity of CAC. Conclusions: Sex-specific relationships between Lp (a) and CAC provide evidence supporting sex-specific risk factor profiling for CAD. In women, Lp(a) alone may be an independent risk factor for coronary atherosclerosis, while in men, Lp (a) may confer higher risk conditional on the presence and level of other risk factors. The role of Lp (a) in the prediction and pathogenesis of subclinical coronary atherosclerosis needs to be further elucidated.

Original languageEnglish (US)
JournalMedical Science Monitor
Volume10
Issue number9
StatePublished - Sep 2004

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Lipoprotein(a)
Coronary Vessels
Coronary Artery Disease
Population
Smoking
LDL Cholesterol
HDL Cholesterol
Hypertension
X Ray Computed Tomography
Waist Circumference
Serum
Body Mass Index

Keywords

  • Atherosclerosis
  • Coronary artery calcification
  • Coronary artery disease
  • Electron beam computed tomography
  • Lipoprotein (a)

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sex-specific association of lipoprotein(a) with presence and quantity of coronary artery calcification in an asymptomatic population. / Cassidy, Andrea E.; Bielak, Lawrence F.; Kullo, Iftikhar Jan; Klee, George G.; Turner, Stephen T; Sheedy, Patrick F.; Peyser, Patricia A.

In: Medical Science Monitor, Vol. 10, No. 9, 09.2004.

Research output: Contribution to journalArticle

Cassidy, Andrea E. ; Bielak, Lawrence F. ; Kullo, Iftikhar Jan ; Klee, George G. ; Turner, Stephen T ; Sheedy, Patrick F. ; Peyser, Patricia A. / Sex-specific association of lipoprotein(a) with presence and quantity of coronary artery calcification in an asymptomatic population. In: Medical Science Monitor. 2004 ; Vol. 10, No. 9.
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abstract = "Background: Lipoprotein(a) (Lp(a)) is a potential risk factor for coronary artery disease (CAD). The relationship between serum Lp (a) and coronary artery calcification (CAC), a measure of subclinical coronary artery atherosclerosis, has not been extensively explored. Material/Methods: Electron beam computed tomography was performed on 616 asymptomatic, white individuals (285 men) from a community-based study. Mean age was 57.2 years. Serum Lp (a) levels were measured by an immunoturbidimetric assay. Tobit regression was used to determine the sex-specific association of Lp (a) levels with presence and quantity of CAC. Results: In women, Lp (a) was a significant predictor (P=0.0426) of presence and quantity of CAC after adjustment for age, hypertension status, waist circumference, presence of high low-density lipoprotein cholesterol (LDL-C), and history of smoking. In men, after adjusting for age, hypertension status, body mass index, presence of high LDL-C, and history of smoking, a positive interaction between Lp (a) and history of smoking (P=0.0387) was significantly associated with presence and quantity of CAC. Conclusions: Sex-specific relationships between Lp (a) and CAC provide evidence supporting sex-specific risk factor profiling for CAD. In women, Lp(a) alone may be an independent risk factor for coronary atherosclerosis, while in men, Lp (a) may confer higher risk conditional on the presence and level of other risk factors. The role of Lp (a) in the prediction and pathogenesis of subclinical coronary atherosclerosis needs to be further elucidated.",
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T1 - Sex-specific association of lipoprotein(a) with presence and quantity of coronary artery calcification in an asymptomatic population

AU - Cassidy, Andrea E.

AU - Bielak, Lawrence F.

AU - Kullo, Iftikhar Jan

AU - Klee, George G.

AU - Turner, Stephen T

AU - Sheedy, Patrick F.

AU - Peyser, Patricia A.

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N2 - Background: Lipoprotein(a) (Lp(a)) is a potential risk factor for coronary artery disease (CAD). The relationship between serum Lp (a) and coronary artery calcification (CAC), a measure of subclinical coronary artery atherosclerosis, has not been extensively explored. Material/Methods: Electron beam computed tomography was performed on 616 asymptomatic, white individuals (285 men) from a community-based study. Mean age was 57.2 years. Serum Lp (a) levels were measured by an immunoturbidimetric assay. Tobit regression was used to determine the sex-specific association of Lp (a) levels with presence and quantity of CAC. Results: In women, Lp (a) was a significant predictor (P=0.0426) of presence and quantity of CAC after adjustment for age, hypertension status, waist circumference, presence of high low-density lipoprotein cholesterol (LDL-C), and history of smoking. In men, after adjusting for age, hypertension status, body mass index, presence of high LDL-C, and history of smoking, a positive interaction between Lp (a) and history of smoking (P=0.0387) was significantly associated with presence and quantity of CAC. Conclusions: Sex-specific relationships between Lp (a) and CAC provide evidence supporting sex-specific risk factor profiling for CAD. In women, Lp(a) alone may be an independent risk factor for coronary atherosclerosis, while in men, Lp (a) may confer higher risk conditional on the presence and level of other risk factors. The role of Lp (a) in the prediction and pathogenesis of subclinical coronary atherosclerosis needs to be further elucidated.

AB - Background: Lipoprotein(a) (Lp(a)) is a potential risk factor for coronary artery disease (CAD). The relationship between serum Lp (a) and coronary artery calcification (CAC), a measure of subclinical coronary artery atherosclerosis, has not been extensively explored. Material/Methods: Electron beam computed tomography was performed on 616 asymptomatic, white individuals (285 men) from a community-based study. Mean age was 57.2 years. Serum Lp (a) levels were measured by an immunoturbidimetric assay. Tobit regression was used to determine the sex-specific association of Lp (a) levels with presence and quantity of CAC. Results: In women, Lp (a) was a significant predictor (P=0.0426) of presence and quantity of CAC after adjustment for age, hypertension status, waist circumference, presence of high low-density lipoprotein cholesterol (LDL-C), and history of smoking. In men, after adjusting for age, hypertension status, body mass index, presence of high LDL-C, and history of smoking, a positive interaction between Lp (a) and history of smoking (P=0.0387) was significantly associated with presence and quantity of CAC. Conclusions: Sex-specific relationships between Lp (a) and CAC provide evidence supporting sex-specific risk factor profiling for CAD. In women, Lp(a) alone may be an independent risk factor for coronary atherosclerosis, while in men, Lp (a) may confer higher risk conditional on the presence and level of other risk factors. The role of Lp (a) in the prediction and pathogenesis of subclinical coronary atherosclerosis needs to be further elucidated.

KW - Atherosclerosis

KW - Coronary artery calcification

KW - Coronary artery disease

KW - Electron beam computed tomography

KW - Lipoprotein (a)

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