Sex and gender influence symptom manifestation and survival in multiple system atrophy

Elizabeth A. Coon; Renee M. Nelson; David M. Sletten; Mariana D. Suarez; J. Eric Ahlskog; Eduardo E. Benarroch; Paola Sandroni; Jay N. Mandrekar; Phillip A. Low; Wolfgang Singer

doi:10.1016/j.autneu.2019.04.002

Sex and gender influence symptom manifestation and survival in multiple system atrophy

Elizabeth A. Coon, Renee M. Nelson, David M. Sletten, Mariana D. Suarez, J. Eric Ahlskog, Eduardo E. Benarroch, Paola Sandroni, Jay N. Mandrekar, Phillip A. Low, Wolfgang Singer

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6 Scopus citations

Abstract

To evaluate the influence of sex and gender on clinical characteristics and survival in multiple system atrophy (MSA), we reviewed MSA patients with autonomic testing 1998–2012. Of 685 patients, 52% were male. Median survival overall was 7.3 years for males, 7.6 years for females. Survival from diagnosis was 2.9 years in males, 3.8 years in females. Females were more likely to initially manifest motor symptoms. Males were more likely to have orthostatic intolerance and early catheterization. In conclusion, our data show longer survival from diagnosis in females and slight overall survival benefit which may be related to initial motor manifestations.

Original language	English (US)
Pages (from-to)	49-52
Number of pages	4
Journal	Autonomic Neuroscience: Basic and Clinical
Volume	219
DOIs	https://doi.org/10.1016/j.autneu.2019.04.002
State	Published - Jul 2019

Keywords

Ataxia
Autonomic
Gender
Multiple system atrophy
Parkinsonism
Sex

ASJC Scopus subject areas

Endocrine and Autonomic Systems
Clinical Neurology
Cellular and Molecular Neuroscience

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10.1016/j.autneu.2019.04.002

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title = "Sex and gender influence symptom manifestation and survival in multiple system atrophy",

abstract = "To evaluate the influence of sex and gender on clinical characteristics and survival in multiple system atrophy (MSA), we reviewed MSA patients with autonomic testing 1998–2012. Of 685 patients, 52% were male. Median survival overall was 7.3 years for males, 7.6 years for females. Survival from diagnosis was 2.9 years in males, 3.8 years in females. Females were more likely to initially manifest motor symptoms. Males were more likely to have orthostatic intolerance and early catheterization. In conclusion, our data show longer survival from diagnosis in females and slight overall survival benefit which may be related to initial motor manifestations.",

keywords = "Ataxia, Autonomic, Gender, Multiple system atrophy, Parkinsonism, Sex",

author = "Coon, {Elizabeth A.} and Nelson, {Renee M.} and Sletten, {David M.} and Suarez, {Mariana D.} and Ahlskog, {J. Eric} and Benarroch, {Eduardo E.} and Paola Sandroni and Mandrekar, {Jay N.} and Low, {Phillip A.} and Wolfgang Singer",

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year = "2019",

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doi = "10.1016/j.autneu.2019.04.002",

language = "English (US)",

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T1 - Sex and gender influence symptom manifestation and survival in multiple system atrophy

AU - Coon, Elizabeth A.

AU - Nelson, Renee M.

AU - Sletten, David M.

AU - Suarez, Mariana D.

AU - Ahlskog, J. Eric

AU - Benarroch, Eduardo E.

AU - Sandroni, Paola

AU - Mandrekar, Jay N.

AU - Low, Phillip A.

AU - Singer, Wolfgang

PY - 2019/7

Y1 - 2019/7

N2 - To evaluate the influence of sex and gender on clinical characteristics and survival in multiple system atrophy (MSA), we reviewed MSA patients with autonomic testing 1998–2012. Of 685 patients, 52% were male. Median survival overall was 7.3 years for males, 7.6 years for females. Survival from diagnosis was 2.9 years in males, 3.8 years in females. Females were more likely to initially manifest motor symptoms. Males were more likely to have orthostatic intolerance and early catheterization. In conclusion, our data show longer survival from diagnosis in females and slight overall survival benefit which may be related to initial motor manifestations.

AB - To evaluate the influence of sex and gender on clinical characteristics and survival in multiple system atrophy (MSA), we reviewed MSA patients with autonomic testing 1998–2012. Of 685 patients, 52% were male. Median survival overall was 7.3 years for males, 7.6 years for females. Survival from diagnosis was 2.9 years in males, 3.8 years in females. Females were more likely to initially manifest motor symptoms. Males were more likely to have orthostatic intolerance and early catheterization. In conclusion, our data show longer survival from diagnosis in females and slight overall survival benefit which may be related to initial motor manifestations.

KW - Ataxia

KW - Autonomic

KW - Gender

KW - Multiple system atrophy

KW - Parkinsonism

KW - Sex

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Sex and gender influence symptom manifestation and survival in multiple system atrophy

Abstract

Keywords

ASJC Scopus subject areas

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