Abstract
We set out to determine factors that influence the rate of brain atrophy in 1-year longitudinal magnetic resonance imaging (MRI) data. With tensor-based morphometry (TBM), we mapped the 3-dimensional profile of progressive atrophy in 144 subjects with probable Alzheimer's disease (AD) (age: 76.5 ± 7.4 years), 338 with amnestic mild cognitive impairment (MCI; 76.0 ± 7.2), and 202 healthy controls (77.0 ± 5.1), scanned twice, 1 year apart. Statistical maps revealed significant age and sex differences in atrophic rates. Brain atrophic rates were about 1%-1.5% faster in women than men. Atrophy was faster in younger than older subjects, most prominently in mild cognitive impairment, with a 1% increase in the rates of atrophy and 2% in ventricular expansion, for every 10-year decrease in age. TBM-derived atrophic rates correlated with reduced beta-amyloid and elevated tau levels (n = 363) at baseline, baseline and progressive deterioration in clinical measures, and increasing numbers of risk alleles for the ApoE4 gene. TBM is a sensitive, high-throughput biomarker for tracking disease progression in large imaging studies; sub-analyses focusing on women or younger subjects gave improved sample size requirements for clinical trials.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1463-1480 |
| Number of pages | 18 |
| Journal | Neurobiology of Aging |
| Volume | 31 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2010 |
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Keywords
- Age
- Alzheimer's disease
- Atrophy rate
- Biomarker
- Drug trial enrichment
- Longitudinal
- Mild cognitive impairment
- MRI
- Neuroimaging
- Sex effect
- Tensor-based morphometry
ASJC Scopus subject areas
- Aging
- Developmental Biology
- Geriatrics and Gerontology
- Clinical Neurology
- Neuroscience(all)
Cite this
Sex and age differences in atrophic rates : An ADNI study with n=1368 MRI scans. / Hua, Xue; Hibar, Derrek P.; Lee, Suh; Toga, Arthur W.; Jack, Clifford R Jr.; Weiner, Michael W.; Thompson, Paul M.
In: Neurobiology of Aging, Vol. 31, No. 8, 08.2010, p. 1463-1480.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sex and age differences in atrophic rates
T2 - An ADNI study with n=1368 MRI scans
AU - Hua, Xue
AU - Hibar, Derrek P.
AU - Lee, Suh
AU - Toga, Arthur W.
AU - Jack, Clifford R Jr.
AU - Weiner, Michael W.
AU - Thompson, Paul M.
PY - 2010/8
Y1 - 2010/8
N2 - We set out to determine factors that influence the rate of brain atrophy in 1-year longitudinal magnetic resonance imaging (MRI) data. With tensor-based morphometry (TBM), we mapped the 3-dimensional profile of progressive atrophy in 144 subjects with probable Alzheimer's disease (AD) (age: 76.5 ± 7.4 years), 338 with amnestic mild cognitive impairment (MCI; 76.0 ± 7.2), and 202 healthy controls (77.0 ± 5.1), scanned twice, 1 year apart. Statistical maps revealed significant age and sex differences in atrophic rates. Brain atrophic rates were about 1%-1.5% faster in women than men. Atrophy was faster in younger than older subjects, most prominently in mild cognitive impairment, with a 1% increase in the rates of atrophy and 2% in ventricular expansion, for every 10-year decrease in age. TBM-derived atrophic rates correlated with reduced beta-amyloid and elevated tau levels (n = 363) at baseline, baseline and progressive deterioration in clinical measures, and increasing numbers of risk alleles for the ApoE4 gene. TBM is a sensitive, high-throughput biomarker for tracking disease progression in large imaging studies; sub-analyses focusing on women or younger subjects gave improved sample size requirements for clinical trials.
AB - We set out to determine factors that influence the rate of brain atrophy in 1-year longitudinal magnetic resonance imaging (MRI) data. With tensor-based morphometry (TBM), we mapped the 3-dimensional profile of progressive atrophy in 144 subjects with probable Alzheimer's disease (AD) (age: 76.5 ± 7.4 years), 338 with amnestic mild cognitive impairment (MCI; 76.0 ± 7.2), and 202 healthy controls (77.0 ± 5.1), scanned twice, 1 year apart. Statistical maps revealed significant age and sex differences in atrophic rates. Brain atrophic rates were about 1%-1.5% faster in women than men. Atrophy was faster in younger than older subjects, most prominently in mild cognitive impairment, with a 1% increase in the rates of atrophy and 2% in ventricular expansion, for every 10-year decrease in age. TBM-derived atrophic rates correlated with reduced beta-amyloid and elevated tau levels (n = 363) at baseline, baseline and progressive deterioration in clinical measures, and increasing numbers of risk alleles for the ApoE4 gene. TBM is a sensitive, high-throughput biomarker for tracking disease progression in large imaging studies; sub-analyses focusing on women or younger subjects gave improved sample size requirements for clinical trials.
KW - Age
KW - Alzheimer's disease
KW - Atrophy rate
KW - Biomarker
KW - Drug trial enrichment
KW - Longitudinal
KW - Mild cognitive impairment
KW - MRI
KW - Neuroimaging
KW - Sex effect
KW - Tensor-based morphometry
UR - http://www.scopus.com/inward/record.url?scp=77954007740&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954007740&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2010.04.033
DO - 10.1016/j.neurobiolaging.2010.04.033
M3 - Article
VL - 31
SP - 1463
EP - 1480
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 8
ER -