Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction

Madhav Swaminathan, Brian J. McCreath, Barbara G. Phillips-Bute, Mark F. Newman, Joseph P. Mathew, Peter K. Smith, James A. Blumenthal, Mark Stafford-Smith, Hilary P. Grocott, Steven E. Hill, J. G. Reves, Debra A. Schwinn, David Warner, Malissa Harris, Jerry L. Kirchner, Brenda Mickley, Mandy Barnes, Elizabeth Carver, Bonita L. Funk, E. D. DerilusJason Hawkins, Terri Moore, Chonna Campbell, Amanda Cheek, Tanya Kagarise, Tori Latiker, Erich Lauff, Melanie Tirronen, Regina DeLacy, William Hansley, Yvonne M. Connelly, William D. White, Michael A. Babyak, Daniel B. Mark, Michael H. Sketch, Carmelo Graffagnino, Daniel T. Laskowitz, John R. Lynch, Ann M. Saunders, Warren J. Strittmatter, Kathleen A. Welsh-Bohmer, Ellen Bennett, Greg Smigla, Ian Shearer, Robert W. Anderson, Thomas A. D'Amico, R. Duane Davis, Donald D. Glower, R. David Harpole, James Jaggers, Robert H. Jones, Kevin Landolfo, James E. Lowe, Robert H. Messier, Carmelo Milano, Eric M. Toloza, Walter G. Wolfe

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Renal dysfunction is common after coronary artery bypass graft (CABG) surgery. We have previously shown that CABG procedures complicated by stroke have a threefold greater peak serum creatinine level relative to uncomplicated surgery. However, postoperative creatinine patterns for procedures complicated by cognitive dysfunction are unknown. Therefore, we tested the hypothesis that postoperative cognitive dysfunction is associated with acute perioperative renal injury after CABG surgery. Data were prospectively gathered for 282 elective CABG surgery patients. Psychometric tests were performed at baseline and 6 wk after surgery. Cognitive dysfunction was defined both as a dichotomous variable (cognitive deficit [CD]) and as a continuous variable (cognitive index). Forty percent of patients had CD at 6 wk. However, the association between peak percentage change in postoperative creatinine and CD (parameter estimate = -0.41; P = 0.91) or cognitive index (parameter estimate = -1.29; P = 0.46) was not significant. These data indicate that postcardiac surgery cognitive dysfunction, unlike stroke, is not associated with major increases in postoperative renal dysfunction.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalAnesthesia and Analgesia
Volume95
Issue number1
StatePublished - 2002
Externally publishedYes

Fingerprint

Coronary Artery Bypass
Creatinine
Transplants
Serum
Stroke
Kidney
Acute Kidney Injury
Psychometrics
Cognitive Dysfunction

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Swaminathan, M., McCreath, B. J., Phillips-Bute, B. G., Newman, M. F., Mathew, J. P., Smith, P. K., ... Wolfe, W. G. (2002). Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction. Anesthesia and Analgesia, 95(1), 1-8.

Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction. / Swaminathan, Madhav; McCreath, Brian J.; Phillips-Bute, Barbara G.; Newman, Mark F.; Mathew, Joseph P.; Smith, Peter K.; Blumenthal, James A.; Stafford-Smith, Mark; Grocott, Hilary P.; Hill, Steven E.; Reves, J. G.; Schwinn, Debra A.; Warner, David; Harris, Malissa; Kirchner, Jerry L.; Mickley, Brenda; Barnes, Mandy; Carver, Elizabeth; Funk, Bonita L.; Derilus, E. D.; Hawkins, Jason; Moore, Terri; Campbell, Chonna; Cheek, Amanda; Kagarise, Tanya; Latiker, Tori; Lauff, Erich; Tirronen, Melanie; DeLacy, Regina; Hansley, William; Connelly, Yvonne M.; White, William D.; Babyak, Michael A.; Mark, Daniel B.; Sketch, Michael H.; Graffagnino, Carmelo; Laskowitz, Daniel T.; Lynch, John R.; Saunders, Ann M.; Strittmatter, Warren J.; Welsh-Bohmer, Kathleen A.; Bennett, Ellen; Smigla, Greg; Shearer, Ian; Anderson, Robert W.; D'Amico, Thomas A.; Duane Davis, R.; Glower, Donald D.; Harpole, R. David; Jaggers, James; Jones, Robert H.; Landolfo, Kevin; Lowe, James E.; Messier, Robert H.; Milano, Carmelo; Toloza, Eric M.; Wolfe, Walter G.

In: Anesthesia and Analgesia, Vol. 95, No. 1, 2002, p. 1-8.

Research output: Contribution to journalArticle

Swaminathan, M, McCreath, BJ, Phillips-Bute, BG, Newman, MF, Mathew, JP, Smith, PK, Blumenthal, JA, Stafford-Smith, M, Grocott, HP, Hill, SE, Reves, JG, Schwinn, DA, Warner, D, Harris, M, Kirchner, JL, Mickley, B, Barnes, M, Carver, E, Funk, BL, Derilus, ED, Hawkins, J, Moore, T, Campbell, C, Cheek, A, Kagarise, T, Latiker, T, Lauff, E, Tirronen, M, DeLacy, R, Hansley, W, Connelly, YM, White, WD, Babyak, MA, Mark, DB, Sketch, MH, Graffagnino, C, Laskowitz, DT, Lynch, JR, Saunders, AM, Strittmatter, WJ, Welsh-Bohmer, KA, Bennett, E, Smigla, G, Shearer, I, Anderson, RW, D'Amico, TA, Duane Davis, R, Glower, DD, Harpole, RD, Jaggers, J, Jones, RH, Landolfo, K, Lowe, JE, Messier, RH, Milano, C, Toloza, EM & Wolfe, WG 2002, 'Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction', Anesthesia and Analgesia, vol. 95, no. 1, pp. 1-8.
Swaminathan M, McCreath BJ, Phillips-Bute BG, Newman MF, Mathew JP, Smith PK et al. Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction. Anesthesia and Analgesia. 2002;95(1):1-8.
Swaminathan, Madhav ; McCreath, Brian J. ; Phillips-Bute, Barbara G. ; Newman, Mark F. ; Mathew, Joseph P. ; Smith, Peter K. ; Blumenthal, James A. ; Stafford-Smith, Mark ; Grocott, Hilary P. ; Hill, Steven E. ; Reves, J. G. ; Schwinn, Debra A. ; Warner, David ; Harris, Malissa ; Kirchner, Jerry L. ; Mickley, Brenda ; Barnes, Mandy ; Carver, Elizabeth ; Funk, Bonita L. ; Derilus, E. D. ; Hawkins, Jason ; Moore, Terri ; Campbell, Chonna ; Cheek, Amanda ; Kagarise, Tanya ; Latiker, Tori ; Lauff, Erich ; Tirronen, Melanie ; DeLacy, Regina ; Hansley, William ; Connelly, Yvonne M. ; White, William D. ; Babyak, Michael A. ; Mark, Daniel B. ; Sketch, Michael H. ; Graffagnino, Carmelo ; Laskowitz, Daniel T. ; Lynch, John R. ; Saunders, Ann M. ; Strittmatter, Warren J. ; Welsh-Bohmer, Kathleen A. ; Bennett, Ellen ; Smigla, Greg ; Shearer, Ian ; Anderson, Robert W. ; D'Amico, Thomas A. ; Duane Davis, R. ; Glower, Donald D. ; Harpole, R. David ; Jaggers, James ; Jones, Robert H. ; Landolfo, Kevin ; Lowe, James E. ; Messier, Robert H. ; Milano, Carmelo ; Toloza, Eric M. ; Wolfe, Walter G. / Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction. In: Anesthesia and Analgesia. 2002 ; Vol. 95, No. 1. pp. 1-8.
@article{4a0c841f9f394758b00cbd5374e2b079,
title = "Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction",
abstract = "Renal dysfunction is common after coronary artery bypass graft (CABG) surgery. We have previously shown that CABG procedures complicated by stroke have a threefold greater peak serum creatinine level relative to uncomplicated surgery. However, postoperative creatinine patterns for procedures complicated by cognitive dysfunction are unknown. Therefore, we tested the hypothesis that postoperative cognitive dysfunction is associated with acute perioperative renal injury after CABG surgery. Data were prospectively gathered for 282 elective CABG surgery patients. Psychometric tests were performed at baseline and 6 wk after surgery. Cognitive dysfunction was defined both as a dichotomous variable (cognitive deficit [CD]) and as a continuous variable (cognitive index). Forty percent of patients had CD at 6 wk. However, the association between peak percentage change in postoperative creatinine and CD (parameter estimate = -0.41; P = 0.91) or cognitive index (parameter estimate = -1.29; P = 0.46) was not significant. These data indicate that postcardiac surgery cognitive dysfunction, unlike stroke, is not associated with major increases in postoperative renal dysfunction.",
author = "Madhav Swaminathan and McCreath, {Brian J.} and Phillips-Bute, {Barbara G.} and Newman, {Mark F.} and Mathew, {Joseph P.} and Smith, {Peter K.} and Blumenthal, {James A.} and Mark Stafford-Smith and Grocott, {Hilary P.} and Hill, {Steven E.} and Reves, {J. G.} and Schwinn, {Debra A.} and David Warner and Malissa Harris and Kirchner, {Jerry L.} and Brenda Mickley and Mandy Barnes and Elizabeth Carver and Funk, {Bonita L.} and Derilus, {E. D.} and Jason Hawkins and Terri Moore and Chonna Campbell and Amanda Cheek and Tanya Kagarise and Tori Latiker and Erich Lauff and Melanie Tirronen and Regina DeLacy and William Hansley and Connelly, {Yvonne M.} and White, {William D.} and Babyak, {Michael A.} and Mark, {Daniel B.} and Sketch, {Michael H.} and Carmelo Graffagnino and Laskowitz, {Daniel T.} and Lynch, {John R.} and Saunders, {Ann M.} and Strittmatter, {Warren J.} and Welsh-Bohmer, {Kathleen A.} and Ellen Bennett and Greg Smigla and Ian Shearer and Anderson, {Robert W.} and D'Amico, {Thomas A.} and {Duane Davis}, R. and Glower, {Donald D.} and Harpole, {R. David} and James Jaggers and Jones, {Robert H.} and Kevin Landolfo and Lowe, {James E.} and Messier, {Robert H.} and Carmelo Milano and Toloza, {Eric M.} and Wolfe, {Walter G.}",
year = "2002",
language = "English (US)",
volume = "95",
pages = "1--8",
journal = "Anesthesia and Analgesia",
issn = "0003-2999",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction

AU - Swaminathan, Madhav

AU - McCreath, Brian J.

AU - Phillips-Bute, Barbara G.

AU - Newman, Mark F.

AU - Mathew, Joseph P.

AU - Smith, Peter K.

AU - Blumenthal, James A.

AU - Stafford-Smith, Mark

AU - Grocott, Hilary P.

AU - Hill, Steven E.

AU - Reves, J. G.

AU - Schwinn, Debra A.

AU - Warner, David

AU - Harris, Malissa

AU - Kirchner, Jerry L.

AU - Mickley, Brenda

AU - Barnes, Mandy

AU - Carver, Elizabeth

AU - Funk, Bonita L.

AU - Derilus, E. D.

AU - Hawkins, Jason

AU - Moore, Terri

AU - Campbell, Chonna

AU - Cheek, Amanda

AU - Kagarise, Tanya

AU - Latiker, Tori

AU - Lauff, Erich

AU - Tirronen, Melanie

AU - DeLacy, Regina

AU - Hansley, William

AU - Connelly, Yvonne M.

AU - White, William D.

AU - Babyak, Michael A.

AU - Mark, Daniel B.

AU - Sketch, Michael H.

AU - Graffagnino, Carmelo

AU - Laskowitz, Daniel T.

AU - Lynch, John R.

AU - Saunders, Ann M.

AU - Strittmatter, Warren J.

AU - Welsh-Bohmer, Kathleen A.

AU - Bennett, Ellen

AU - Smigla, Greg

AU - Shearer, Ian

AU - Anderson, Robert W.

AU - D'Amico, Thomas A.

AU - Duane Davis, R.

AU - Glower, Donald D.

AU - Harpole, R. David

AU - Jaggers, James

AU - Jones, Robert H.

AU - Landolfo, Kevin

AU - Lowe, James E.

AU - Messier, Robert H.

AU - Milano, Carmelo

AU - Toloza, Eric M.

AU - Wolfe, Walter G.

PY - 2002

Y1 - 2002

N2 - Renal dysfunction is common after coronary artery bypass graft (CABG) surgery. We have previously shown that CABG procedures complicated by stroke have a threefold greater peak serum creatinine level relative to uncomplicated surgery. However, postoperative creatinine patterns for procedures complicated by cognitive dysfunction are unknown. Therefore, we tested the hypothesis that postoperative cognitive dysfunction is associated with acute perioperative renal injury after CABG surgery. Data were prospectively gathered for 282 elective CABG surgery patients. Psychometric tests were performed at baseline and 6 wk after surgery. Cognitive dysfunction was defined both as a dichotomous variable (cognitive deficit [CD]) and as a continuous variable (cognitive index). Forty percent of patients had CD at 6 wk. However, the association between peak percentage change in postoperative creatinine and CD (parameter estimate = -0.41; P = 0.91) or cognitive index (parameter estimate = -1.29; P = 0.46) was not significant. These data indicate that postcardiac surgery cognitive dysfunction, unlike stroke, is not associated with major increases in postoperative renal dysfunction.

AB - Renal dysfunction is common after coronary artery bypass graft (CABG) surgery. We have previously shown that CABG procedures complicated by stroke have a threefold greater peak serum creatinine level relative to uncomplicated surgery. However, postoperative creatinine patterns for procedures complicated by cognitive dysfunction are unknown. Therefore, we tested the hypothesis that postoperative cognitive dysfunction is associated with acute perioperative renal injury after CABG surgery. Data were prospectively gathered for 282 elective CABG surgery patients. Psychometric tests were performed at baseline and 6 wk after surgery. Cognitive dysfunction was defined both as a dichotomous variable (cognitive deficit [CD]) and as a continuous variable (cognitive index). Forty percent of patients had CD at 6 wk. However, the association between peak percentage change in postoperative creatinine and CD (parameter estimate = -0.41; P = 0.91) or cognitive index (parameter estimate = -1.29; P = 0.46) was not significant. These data indicate that postcardiac surgery cognitive dysfunction, unlike stroke, is not associated with major increases in postoperative renal dysfunction.

UR - http://www.scopus.com/inward/record.url?scp=0036294908&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036294908&partnerID=8YFLogxK

M3 - Article

C2 - 12088934

AN - SCOPUS:0036294908

VL - 95

SP - 1

EP - 8

JO - Anesthesia and Analgesia

JF - Anesthesia and Analgesia

SN - 0003-2999

IS - 1

ER -