Serology of celiac disease in gluten-sensitive ataxia or neuropathy: Role of deamidated gliadin antibody

Shahrooz Rashtak, Shadi Rashtak, Melissa R. Snyder, Sean J. Pittock, Tsung Teh Wu, Manish J. Gandhi, Joseph A. Murray

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The role and relevance of deamidated gliadin antibodies specific for celiac disease in gluten-sensitive ataxia/neuropathy is unknown. We investigated the association of celiac-specific serology with gluten-sensitive ataxia/neuropathy, in patients with and without gliadin-induced enteropathy. 51 patients with unexplained ataxia/neuropathy suspected to have gluten sensitivity were included in the study and their serum celiac-specific markers were measured. Deamidated gliadin-IgA (83% vs. 22%), deamidated gliadin-IgG (50% vs. 3%), tissue transglutaminase-IgA (78% vs. 11%), and anti-endomysial-IgA (70% vs. 0%), were significantly more positive in ataxia/neuropathy patients with celiac disease versus those without enteropathy (P< 0.001). Our findings suggest that the serological profile of gluten-sensitive ataxia/neuropathy without intestinal involvement lacks the recognition of deamidated gliadin and tissue transglutaminase epitopes.

Original languageEnglish (US)
Pages (from-to)130-134
Number of pages5
JournalJournal of neuroimmunology
Volume230
Issue number1-2
DOIs
StatePublished - Jan 2011

Keywords

  • Ataxia
  • Celiac disease
  • Deamidated gliadin antibody
  • Gluten sensitivity
  • Neuropathy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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