Serology of celiac disease in gluten-sensitive ataxia or neuropathy: Role of deamidated gliadin antibody

Shahrooz Rashtak, Shadi Rashtak, Melissa R. Snyder, Sean J Pittock, Tsung Teh Wu, Manish J. Gandhi, Joseph A Murray

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The role and relevance of deamidated gliadin antibodies specific for celiac disease in gluten-sensitive ataxia/neuropathy is unknown. We investigated the association of celiac-specific serology with gluten-sensitive ataxia/neuropathy, in patients with and without gliadin-induced enteropathy. 51 patients with unexplained ataxia/neuropathy suspected to have gluten sensitivity were included in the study and their serum celiac-specific markers were measured. Deamidated gliadin-IgA (83% vs. 22%), deamidated gliadin-IgG (50% vs. 3%), tissue transglutaminase-IgA (78% vs. 11%), and anti-endomysial-IgA (70% vs. 0%), were significantly more positive in ataxia/neuropathy patients with celiac disease versus those without enteropathy (P< 0.001). Our findings suggest that the serological profile of gluten-sensitive ataxia/neuropathy without intestinal involvement lacks the recognition of deamidated gliadin and tissue transglutaminase epitopes.

Original languageEnglish (US)
Pages (from-to)130-134
Number of pages5
JournalJournal of Neuroimmunology
Volume230
Issue number1-2
DOIs
StatePublished - Jan 2011

Fingerprint

Gliadin
Glutens
Celiac Disease
Serology
Ataxia
Antibodies
Abdomen
Immunoglobulin A
Epitopes
Immunoglobulin G
Serum

Keywords

  • Ataxia
  • Celiac disease
  • Deamidated gliadin antibody
  • Gluten sensitivity
  • Neuropathy

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Serology of celiac disease in gluten-sensitive ataxia or neuropathy : Role of deamidated gliadin antibody. / Rashtak, Shahrooz; Rashtak, Shadi; Snyder, Melissa R.; Pittock, Sean J; Wu, Tsung Teh; Gandhi, Manish J.; Murray, Joseph A.

In: Journal of Neuroimmunology, Vol. 230, No. 1-2, 01.2011, p. 130-134.

Research output: Contribution to journalArticle

Rashtak, Shahrooz ; Rashtak, Shadi ; Snyder, Melissa R. ; Pittock, Sean J ; Wu, Tsung Teh ; Gandhi, Manish J. ; Murray, Joseph A. / Serology of celiac disease in gluten-sensitive ataxia or neuropathy : Role of deamidated gliadin antibody. In: Journal of Neuroimmunology. 2011 ; Vol. 230, No. 1-2. pp. 130-134.
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