Serologic and biochemical identification of minor histocompatibility (H-4) antigens

P. M. Long, W. P. Lafuse, C. S. David

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Mouse alloantiserum capable of detecting minor histocompatibility antigens has been produced. Cytotoxic antibody to products of the H-4 locus was produced by reciprocal immunization of minor H loci congenic strains B10 (H-4a) and B10.129(21M) (H-4b), with mitogen-stimulated lymphocytes and epidermal cells. Absorption studies suggested antibodies to more than 1 specificity. The antibodies cross-react with products of other minor H loci. Alloantiserum to the H-4 gene product precipitates a glycoprotein with a m.w. of approximately 45,000 from radiolabeled Con A-stimulated lymph node cells.

Original languageEnglish (US)
Pages (from-to)825-828
Number of pages4
JournalJournal of Immunology
Volume127
Issue number3
StatePublished - 1981

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Histocompatibility
Antibodies
Minor Histocompatibility Antigens
Mitogens
Immunization
Glycoproteins
Lymph Nodes
Lymphocytes
Genes
H antigen

ASJC Scopus subject areas

  • Immunology

Cite this

Long, P. M., Lafuse, W. P., & David, C. S. (1981). Serologic and biochemical identification of minor histocompatibility (H-4) antigens. Journal of Immunology, 127(3), 825-828.

Serologic and biochemical identification of minor histocompatibility (H-4) antigens. / Long, P. M.; Lafuse, W. P.; David, C. S.

In: Journal of Immunology, Vol. 127, No. 3, 1981, p. 825-828.

Research output: Contribution to journalArticle

Long, PM, Lafuse, WP & David, CS 1981, 'Serologic and biochemical identification of minor histocompatibility (H-4) antigens', Journal of Immunology, vol. 127, no. 3, pp. 825-828.
Long, P. M. ; Lafuse, W. P. ; David, C. S. / Serologic and biochemical identification of minor histocompatibility (H-4) antigens. In: Journal of Immunology. 1981 ; Vol. 127, No. 3. pp. 825-828.
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