Serologic and biochemical identification of minor histocompatibility (H-4) antigens

P. M. Long, W. P. Lafuse, C. S. David

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Mouse alloantiserum capable of detecting minor histocompatibility antigens has been produced. Cytotoxic antibody to products of the H-4 locus was produced by reciprocal immunization of minor H loci congenic strains B10 (H-4a) and B10.129(21M) (H-4b), with mitogen-stimulated lymphocytes and epidermal cells. Absorption studies suggested antibodies to more than 1 specificity. The antibodies cross-react with products of other minor H loci. Alloantiserum to the H-4 gene product precipitates a glycoprotein with a m.w. of approximately 45,000 from radiolabeled Con A-stimulated lymph node cells.

Original languageEnglish (US)
Pages (from-to)825-828
Number of pages4
JournalJournal of Immunology
Volume127
Issue number3
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Long, P. M., Lafuse, W. P., & David, C. S. (1981). Serologic and biochemical identification of minor histocompatibility (H-4) antigens. Journal of Immunology, 127(3), 825-828.