Abstract
Mouse alloantiserum capable of detecting minor histocompatibility antigens has been produced. Cytotoxic antibody to products of the H-4 locus was produced by reciprocal immunization of minor H loci congenic strains B10 (H-4a) and B10.129(21M) (H-4b), with mitogen-stimulated lymphocytes and epidermal cells. Absorption studies suggested antibodies to more than 1 specificity. The antibodies cross-react with products of other minor H loci. Alloantiserum to the H-4 gene product precipitates a glycoprotein with a m.w. of approximately 45,000 from radiolabeled Con A-stimulated lymph node cells.
Original language | English (US) |
---|---|
Pages (from-to) | 825-828 |
Number of pages | 4 |
Journal | Journal of Immunology |
Volume | 127 |
Issue number | 3 |
State | Published - 1981 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology