Seroconversion to human herpesvirus 6 following liver transplantation is a marker of cytomegalovirus disease

David H. Dockrell, Jose Prada, Mary F. Joncs, Robin Patel, Andrew David Badley, William S. Harmsen, Duane M. Ilstrup, Russell H. Wiesner, Ruud A F Krom, Thomas F. Smith, Carlos V. Paya

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Abstract

Human herpesvirus 6 (HHV-6) infection is common after transplantation; HHV-6 is known to interact with other viruses and induce immunosuppression. Whether HHV-6 plays a role in the occurrence of cytomegalovirus (CMV) infection after transplantation was investigated. In a cohort of 247 liver transplant recipients, HHV-6 seroconversion was identified as a significant risk factor for development of symptomatic CMV infection (P < .001), including CMV organ involvement (P < .001), even in the presence of the other significant risk factors: D+/R- CMV serologic status (P < .001) or use of OKT3 after transplantation (P = .002). Subgroup analysis indicated that HHV- 6 seroconversion was significantly associated with symptomatic CMV infection in the D+/R+ but not in the D+/R- CMV serologic group (P < .001 and P = .11, respectively). These results indicate that HHV-6 seroconversion is a marker for CMV disease after transplantation and suggest that additional studies using more sensitive diagnostic techniques are warranted to determine the relationship between HHV-6 and CMV infection after transplantation.

Original languageEnglish (US)
Pages (from-to)1135-1140
Number of pages6
JournalJournal of Infectious Diseases
Volume176
Issue number5
StatePublished - 1997

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Human Herpesvirus 6
Cytomegalovirus
Liver Transplantation
Cytomegalovirus Infections
Transplantation
Herpesviridae Infections
Muromonab-CD3
Seroconversion
Immunosuppression
Viruses
Liver

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Seroconversion to human herpesvirus 6 following liver transplantation is a marker of cytomegalovirus disease. / Dockrell, David H.; Prada, Jose; Joncs, Mary F.; Patel, Robin; Badley, Andrew David; Harmsen, William S.; Ilstrup, Duane M.; Wiesner, Russell H.; Krom, Ruud A F; Smith, Thomas F.; Paya, Carlos V.

In: Journal of Infectious Diseases, Vol. 176, No. 5, 1997, p. 1135-1140.

Research output: Contribution to journalArticle

Dockrell, DH, Prada, J, Joncs, MF, Patel, R, Badley, AD, Harmsen, WS, Ilstrup, DM, Wiesner, RH, Krom, RAF, Smith, TF & Paya, CV 1997, 'Seroconversion to human herpesvirus 6 following liver transplantation is a marker of cytomegalovirus disease', Journal of Infectious Diseases, vol. 176, no. 5, pp. 1135-1140.
Dockrell, David H. ; Prada, Jose ; Joncs, Mary F. ; Patel, Robin ; Badley, Andrew David ; Harmsen, William S. ; Ilstrup, Duane M. ; Wiesner, Russell H. ; Krom, Ruud A F ; Smith, Thomas F. ; Paya, Carlos V. / Seroconversion to human herpesvirus 6 following liver transplantation is a marker of cytomegalovirus disease. In: Journal of Infectious Diseases. 1997 ; Vol. 176, No. 5. pp. 1135-1140.
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