Sequence variation of Epstein-Barr virus (EBV) BCRF1 in lymphomas in non-endemic areas of nasopharyngeal carcinoma

Lu Han, Lingling Sun, Zhenzhen Zhao, Yan Chao, Zhifu Sun, Hui Li, Bing Luo

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

To characterize the sequence variation and the potential implication of the Epstein-Barr virus (EBV) oncogene in lymphoma, BamHI-C fragment rightward reading frame 1 (BCRF1) was sequenced in different types of EBV-positive lymphoma in northern China, and polymorphisms were compared with previous variation data from other malignancies. The dominate subtype of BCRF1 in EBV-positive lymphoma was the B95-8 prototype, and a mutation in the signal peptide was more strongly associated with Hodgkin’s lymphoma. The high conservation of BCRF1 in EBV-positive lymphoma suggests its important role in maintaining the basic biological activity and immunosuppressive functions of the virus.

Original languageEnglish (US)
Pages (from-to)441-445
Number of pages5
JournalArchives of Virology
Volume160
Issue number2
DOIs
StatePublished - Feb 2014

ASJC Scopus subject areas

  • Virology

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