Sequence variation of Epstein-Barr virus (EBV) BCRF1 in lymphomas in non-endemic areas of nasopharyngeal carcinoma

Lu Han; Lingling Sun; Zhenzhen Zhao; Yan Chao; Zhifu Sun; Hui Li; Bing Luo

doi:10.1007/s00705-014-2279-9

Sequence variation of Epstein-Barr virus (EBV) BCRF1 in lymphomas in non-endemic areas of nasopharyngeal carcinoma

Lu Han, Lingling Sun, Zhenzhen Zhao, Yan Chao, Zhifu Sun, Hui Li, Bing Luo

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

To characterize the sequence variation and the potential implication of the Epstein-Barr virus (EBV) oncogene in lymphoma, BamHI-C fragment rightward reading frame 1 (BCRF1) was sequenced in different types of EBV-positive lymphoma in northern China, and polymorphisms were compared with previous variation data from other malignancies. The dominate subtype of BCRF1 in EBV-positive lymphoma was the B95-8 prototype, and a mutation in the signal peptide was more strongly associated with Hodgkin’s lymphoma. The high conservation of BCRF1 in EBV-positive lymphoma suggests its important role in maintaining the basic biological activity and immunosuppressive functions of the virus.

Original language	English (US)
Pages (from-to)	441-445
Number of pages	5
Journal	Archives of Virology
Volume	160
Issue number	2
DOIs	https://doi.org/10.1007/s00705-014-2279-9
State	Published - Feb 2014

ASJC Scopus subject areas

Virology

Access to Document

10.1007/s00705-014-2279-9

Cite this

@article{e1bc5aa764a34f10ab51ffc3fbb3e3a6,

title = "Sequence variation of Epstein-Barr virus (EBV) BCRF1 in lymphomas in non-endemic areas of nasopharyngeal carcinoma",

abstract = "To characterize the sequence variation and the potential implication of the Epstein-Barr virus (EBV) oncogene in lymphoma, BamHI-C fragment rightward reading frame 1 (BCRF1) was sequenced in different types of EBV-positive lymphoma in northern China, and polymorphisms were compared with previous variation data from other malignancies. The dominate subtype of BCRF1 in EBV-positive lymphoma was the B95-8 prototype, and a mutation in the signal peptide was more strongly associated with Hodgkin{\textquoteright}s lymphoma. The high conservation of BCRF1 in EBV-positive lymphoma suggests its important role in maintaining the basic biological activity and immunosuppressive functions of the virus.",

author = "Lu Han and Lingling Sun and Zhenzhen Zhao and Yan Chao and Zhifu Sun and Hui Li and Bing Luo",

note = "Publisher Copyright: {\textcopyright} 2014, Springer-Verlag Wien.",

year = "2014",

month = feb,

doi = "10.1007/s00705-014-2279-9",

language = "English (US)",

volume = "160",

pages = "441--445",

journal = "Archives of Virology",

issn = "0304-8608",

publisher = "Springer Wien",

number = "2",

}

TY - JOUR

T1 - Sequence variation of Epstein-Barr virus (EBV) BCRF1 in lymphomas in non-endemic areas of nasopharyngeal carcinoma

AU - Han, Lu

AU - Sun, Lingling

AU - Zhao, Zhenzhen

AU - Chao, Yan

AU - Sun, Zhifu

AU - Li, Hui

AU - Luo, Bing

PY - 2014/2

Y1 - 2014/2

N2 - To characterize the sequence variation and the potential implication of the Epstein-Barr virus (EBV) oncogene in lymphoma, BamHI-C fragment rightward reading frame 1 (BCRF1) was sequenced in different types of EBV-positive lymphoma in northern China, and polymorphisms were compared with previous variation data from other malignancies. The dominate subtype of BCRF1 in EBV-positive lymphoma was the B95-8 prototype, and a mutation in the signal peptide was more strongly associated with Hodgkin’s lymphoma. The high conservation of BCRF1 in EBV-positive lymphoma suggests its important role in maintaining the basic biological activity and immunosuppressive functions of the virus.

AB - To characterize the sequence variation and the potential implication of the Epstein-Barr virus (EBV) oncogene in lymphoma, BamHI-C fragment rightward reading frame 1 (BCRF1) was sequenced in different types of EBV-positive lymphoma in northern China, and polymorphisms were compared with previous variation data from other malignancies. The dominate subtype of BCRF1 in EBV-positive lymphoma was the B95-8 prototype, and a mutation in the signal peptide was more strongly associated with Hodgkin’s lymphoma. The high conservation of BCRF1 in EBV-positive lymphoma suggests its important role in maintaining the basic biological activity and immunosuppressive functions of the virus.

UR - http://www.scopus.com/inward/record.url?scp=84925486738&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925486738&partnerID=8YFLogxK

U2 - 10.1007/s00705-014-2279-9

DO - 10.1007/s00705-014-2279-9

M3 - Article

C2 - 25373543

AN - SCOPUS:84925486738

SN - 0304-8608

VL - 160

SP - 441

EP - 445

JO - Archives of Virology

JF - Archives of Virology

IS - 2

ER -

Sequence variation of Epstein-Barr virus (EBV) BCRF1 in lymphomas in non-endemic areas of nasopharyngeal carcinoma

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this