@article{89a0a8eca34c4c6b8bfa597ed5b84511,
title = "Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases",
abstract = "Aging is a major risk factor for numerous human pathologies, including cardiovascular, metabolic, musculoskeletal, and neurodegenerative conditions and various malignancies. While our understanding of aging is far from complete, recent advances suggest that targeting fundamental aging processes can delay, prevent, or alleviate age-related disorders. Cellular senescence is physiologically beneficial in several contexts, but it has causal roles in multiple chronic diseases. New studies have illustrated the promising feasibility and safety to selectively ablate senescent cells from tissues, a therapeutic modality that holds potential for treating multiple chronic pathologies and extending human healthspan. Here, we review molecular links between cellular senescence and age-associated complications and highlight novel therapeutic avenues that may be exploited to target senescent cells in future geriatric medicine.",
keywords = "SASP, cellular senescence, clinical trials, geroscience, senolytics",
author = "Shuling Song and Lam, {Eric W.F.} and Tamara Tchkonia and Kirkland, {James L.} and Yu Sun",
note = "Funding Information: The authors apologize to colleagues whose work in aging, cellular senescence, and chronic diseases could not be cited due to space limitations. We are grateful to members of the Sun Laboratory for inspiring discussions and insightful comments about the manuscript. This work is supported in part by grants from the National Key Research and Development Program of China ( 2016YFC1302400 ), the National Natural Science Foundation of China (NSFC) ( 81472709 , 31671425 , 31871380 ), the Key Lab of Tissue Microenvironment and Tumor of Chinese Academy of Sciences , the National 1000 Young Talents Research Program of China , the University and Locality Collaborative Development Program of Yantai ( 2019XDRHXMRC08 ), and the U.S. Department of Defense (DoD) Prostate Cancer Research Program (PCRP) (Idea Development Award PC111703) to Y.S.; CRUK ( A12011 ), Breast Cancer Now ( 2012MayPR070 ; 2012NovPhD016 ), the Medical Research Council of the United Kingdom ( MR/N012097/1 ), the Cancer Research UK Imperial Centre, Imperial ECMC and NIHR Imperial BRC to E.W-F.L.; and US National Institutes of Health grants R37-AG013925 and P01 AG062413 , the Connor Fund , Robert J. and Theresa W. Ryan , and the Noaber Foundation to J.L.K. Funding Information: The authors apologize to colleagues whose work in aging, cellular senescence, and chronic diseases could not be cited due to space limitations. We are grateful to members of the Sun Laboratory for inspiring discussions and insightful comments about the manuscript. This work is supported in part by grants from the National Key Research and Development Program of China (2016YFC1302400), the National Natural Science Foundation of China (NSFC) (81472709, 31671425, 31871380), the Key Lab of Tissue Microenvironment and Tumor of Chinese Academy of Sciences, the National 1000 Young Talents Research Program of China, the University and Locality Collaborative Development Program of Yantai (2019XDRHXMRC08), and the U.S. Department of Defense (DoD) Prostate Cancer Research Program (PCRP) (Idea Development Award PC111703) to Y.S.; CRUK (A12011), Breast Cancer Now (2012MayPR070; 2012NovPhD016), the Medical Research Council of the United Kingdom (MR/N012097/1), the Cancer Research UK Imperial Centre, Imperial ECMC and NIHR Imperial BRC to E.W-F.L.; and US National Institutes of Health grants R37-AG013925 and P01 AG062413, the Connor Fund, Robert J. and Theresa W. Ryan, and the Noaber Foundation to J.L.K. J.L.K. and T.T. have a financial interest related to this research. Patents on senolytic drugs are held by the Mayo Clinic. This research has been reviewed by the Mayo Clinic Conflict of Interest Review Board and was conducted in compliance with Mayo Clinic Conflict of Interest policies. Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",
year = "2020",
month = jul,
doi = "10.1016/j.tibs.2020.03.008",
language = "English (US)",
volume = "45",
pages = "578--592",
journal = "Trends in Biochemical Sciences",
issn = "0376-5067",
publisher = "Elsevier Limited",
number = "7",
}