Senescent cells: A therapeutic target for cardiovascular disease

Bennett G. Childs, Hu Li, Jan Van Deursen

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

Cellular senescence, a major tumor-suppressive cell fate, has emerged from humble beginnings as an in vitro phenomenon into recognition as a fundamental mechanism of aging. In the process, senescent cells have attracted attention as a therapeutic target for age-related diseases, including cardiovascular disease (CVD), the leading cause of morbidity and mortality in the elderly. Given the aging global population and the inadequacy of current medical management, attenuating the health care burden of CVD would be transformative to clinical practice. Here, we review the evidence that cellular senescence drives CVD in a bimodal fashion by both priming the aged cardiovascular system for disease and driving established disease forward. Hence, the growing field of senotherapy (neutralizing senescent cells for therapeutic benefit) is poised to contribute to both prevention and treatment of CVD.

Original languageEnglish (US)
Pages (from-to)1217-1228
Number of pages12
JournalJournal of Clinical Investigation
Volume128
Issue number4
DOIs
StatePublished - Apr 2 2018

ASJC Scopus subject areas

  • Medicine(all)

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