@inproceedings{a53c35f1a4c34ad0a20923875f736105,
title = "Semantic Web Ontology and Data Integration: A Case Study in Aiding Psychiatric Drug Repurposing",
abstract = "There remain significant difficulties selecting probable candidate drugs from existing databases. We describe an ontology-oriented approach to represent the nexus between genes, drugs, phenotypes, symptoms, and diseases from multiple information sources. We also report a case study in which we attempted to explore candidate drugs effective for bipolar disorder and epilepsy. We constructed an ontology incorporating knowledge between the two diseases and performed semantic reasoning tasks with the ontology. The results suggested 48 candidate drugs that hold promise for further breakthrough. The evaluation demonstrated the validity our approach. Our approach prioritizes the candidate drugs that have potential associations among genes, phenotypes and symptoms, and thus facilitates the data integration and drug repurposing in psychiatric disorders.",
keywords = "Data Integration, Drug Repurposing, Ontology",
author = "Chen Liang and Jingchun Sun and Cui Tao",
note = "Publisher Copyright: {\textcopyright} 2015 IMIA and IOS Press.; 15th World Congress on Health and Biomedical Informatics, MEDINFO 2015 ; Conference date: 19-08-2015 Through 23-08-2015",
year = "2015",
doi = "10.3233/978-1-61499-564-7-1051",
language = "English (US)",
series = "Studies in Health Technology and Informatics",
publisher = "IOS Press",
pages = "1051",
editor = "Andrew Georgiou and Sarkar, {Indra Neil} and {de Azevedo Marques}, {Paulo Mazzoncini}",
booktitle = "MEDINFO 2015",
}