Selective central nervous system tropism of primary central nervous system lymphoma

Liuyan Jiang; Laura A. Marlow; Simon J. Cooper; Christina V. Roemeling; David M. Menke; John A. Copland; Han W. Tun

Selective central nervous system tropism of primary central nervous system lymphoma

Liuyan Jiang, Laura A. Marlow, Simon J. Cooper, Christina V. Roemeling, David M. Menke, John A. Copland, Han W. Tun

Research output: Contribution to journal › Article › peer-review

Abstract

Primary Central nervous system lymphoma (PCNSL) is most frequently a diffuse large B cell lymphoma (DLBCL), which is confined to the Central nervous system (CNS). We performed an experiment in which lymphoma cells from a PCNSL patient were implanted subcutaneously in an athymic mouse. The lymphoma cells were shown to home to the CNS with histologic evaluations of the brain showing multiple large B cells in blood vessels consistent with intravascular large B cell lymphoma (IVL). We did not find any evidence of lymphoma at the site of implantation or other locations. The findings are consistent with highly selective tropism of PCNSL for the CNS and its vasculature.

Original language	English (US)
Pages (from-to)	763-767
Number of pages	5
Journal	International Journal of Clinical and Experimental Pathology
Volume	3
Issue number	8
State	Published - 2010

Keywords

Central nervous system
Lymphoma
Tropism

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology

Cite this

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title = "Selective central nervous system tropism of primary central nervous system lymphoma",

abstract = "Primary Central nervous system lymphoma (PCNSL) is most frequently a diffuse large B cell lymphoma (DLBCL), which is confined to the Central nervous system (CNS). We performed an experiment in which lymphoma cells from a PCNSL patient were implanted subcutaneously in an athymic mouse. The lymphoma cells were shown to home to the CNS with histologic evaluations of the brain showing multiple large B cells in blood vessels consistent with intravascular large B cell lymphoma (IVL). We did not find any evidence of lymphoma at the site of implantation or other locations. The findings are consistent with highly selective tropism of PCNSL for the CNS and its vasculature.",

keywords = "Central nervous system, Lymphoma, Tropism",

author = "Liuyan Jiang and Marlow, {Laura A.} and Cooper, {Simon J.} and Roemeling, {Christina V.} and Menke, {David M.} and Copland, {John A.} and Tun, {Han W.}",

year = "2010",

language = "English (US)",

volume = "3",

pages = "763--767",

journal = "International Journal of Clinical and Experimental Pathology",

issn = "1936-2625",

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TY - JOUR

T1 - Selective central nervous system tropism of primary central nervous system lymphoma

AU - Jiang, Liuyan

AU - Marlow, Laura A.

AU - Cooper, Simon J.

AU - Roemeling, Christina V.

AU - Menke, David M.

AU - Copland, John A.

AU - Tun, Han W.

PY - 2010

Y1 - 2010

N2 - Primary Central nervous system lymphoma (PCNSL) is most frequently a diffuse large B cell lymphoma (DLBCL), which is confined to the Central nervous system (CNS). We performed an experiment in which lymphoma cells from a PCNSL patient were implanted subcutaneously in an athymic mouse. The lymphoma cells were shown to home to the CNS with histologic evaluations of the brain showing multiple large B cells in blood vessels consistent with intravascular large B cell lymphoma (IVL). We did not find any evidence of lymphoma at the site of implantation or other locations. The findings are consistent with highly selective tropism of PCNSL for the CNS and its vasculature.

AB - Primary Central nervous system lymphoma (PCNSL) is most frequently a diffuse large B cell lymphoma (DLBCL), which is confined to the Central nervous system (CNS). We performed an experiment in which lymphoma cells from a PCNSL patient were implanted subcutaneously in an athymic mouse. The lymphoma cells were shown to home to the CNS with histologic evaluations of the brain showing multiple large B cells in blood vessels consistent with intravascular large B cell lymphoma (IVL). We did not find any evidence of lymphoma at the site of implantation or other locations. The findings are consistent with highly selective tropism of PCNSL for the CNS and its vasculature.

KW - Central nervous system

KW - Lymphoma

KW - Tropism

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M3 - Article

C2 - 21151389

AN - SCOPUS:79953148896

SN - 1936-2625

VL - 3

SP - 763

EP - 767

JO - International Journal of Clinical and Experimental Pathology

JF - International Journal of Clinical and Experimental Pathology

IS - 8

ER -

Selective central nervous system tropism of primary central nervous system lymphoma

Abstract

Keywords

ASJC Scopus subject areas

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