Selective central nervous system tropism of primary central nervous system lymphoma

Liuyan Jiang, Laura A. Marlow, Simon J. Cooper, Christina V. Roemeling, David M. Menke, John A. Copland, Han W. Tun

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Primary Central nervous system lymphoma (PCNSL) is most frequently a diffuse large B cell lymphoma (DLBCL), which is confined to the Central nervous system (CNS). We performed an experiment in which lymphoma cells from a PCNSL patient were implanted subcutaneously in an athymic mouse. The lymphoma cells were shown to home to the CNS with histologic evaluations of the brain showing multiple large B cells in blood vessels consistent with intravascular large B cell lymphoma (IVL). We did not find any evidence of lymphoma at the site of implantation or other locations. The findings are consistent with highly selective tropism of PCNSL for the CNS and its vasculature.

Original languageEnglish (US)
Pages (from-to)763-767
Number of pages5
JournalInternational Journal of Clinical and Experimental Pathology
Volume3
Issue number8
StatePublished - Dec 1 2010

Keywords

  • Central nervous system
  • Lymphoma
  • Tropism

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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