Selecting an Appropriate Experimental Animal Model for Cholangiocarcinoma Research

Man Li, Xueli Zhou, Wei Wang, Baoan Ji, Yu Shao, Qianyu Du, Jinghao Yao, Yan Yang

Research output: Contribution to journalReview articlepeer-review

Abstract

Cholangiocarcinoma (CCA) is a highly aggressive biliary tree malignancy with intrahepatic and extra-hepatic subtypes that differ in molecular pathogeneses, epidemiology, clinical manifestations, treatment, and prognosis. The overall prognosis and patient survival remains poor because of lack of early diagnosis and effective treatments. Preclinical in vivo studies have become increasingly paramount as they are helpful not only for the study of the fundamental molecular mechanisms of CCA but also for developing novel and effective therapeutic approaches of this fatal cancer. Recent advancements in cell and molecular biology have made it possible to mimic the pathogenicity of human CCA in chemical-mechanical, infection-induced inflammatory, implantation, and genetically engineered animal models. This review is intended to help investigators understand the particular strengths and weaknesses of the currently used in vivo animal models of human CCA and their related modeling techniques to aid in the selection of the one that is the best for their research needs.

Original languageEnglish (US)
Pages (from-to)700-710
Number of pages11
JournalJournal of Clinical and Translational Hepatology
Volume10
Issue number4
DOIs
StatePublished - Aug 2022

Keywords

  • Animal model
  • Cancer cell of origin
  • Cholangiocarcinoma
  • Genetically engineered model
  • Heterogeneity

ASJC Scopus subject areas

  • Hepatology

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