Abstract
The dystrophin gene, located at chromosome Xp21, was evaluated as a candidate gene in chronic schizophrenia in response to the report of a large family in which schizophrenia cosegregated with Becker muscular dystrophy [Zatz et al., 1991: Am J Hum Genet 49: A364; 1992: J Med Genet 30(2):131- 134]. Genomic DNA from 94 men with chronic schizophrenia was evaluated by Southern blot analysis using cDNA probes that span exons 1-59. No exonic deletions were identified. An unexpectedly high rate of polymorphism was calculated in this study and two novel polymorphisms were found, demonstrating the usefulness of the candidate gene approach even when results of the original study are negative.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-4 |
| Number of pages | 4 |
| Journal | American Journal of Medical Genetics |
| Volume | 54 |
| Issue number | 1 |
| State | Published - 1994 |
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Keywords
- dystrophin gene
- polymorphism
- polymorphism rate
- schizophrenia
ASJC Scopus subject areas
- Genetics(clinical)
Cite this
Screening the dystrophin gene suggests a high rate of polymorphism in general but no exonic deletions in schizophrenics. / Lindor, Noralane Morey; Sobell, J. L.; Heston, L. L.; Thibodeau, Stephen N; Sommer, S. S.
In: American Journal of Medical Genetics, Vol. 54, No. 1, 1994, p. 1-4.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Screening the dystrophin gene suggests a high rate of polymorphism in general but no exonic deletions in schizophrenics
AU - Lindor, Noralane Morey
AU - Sobell, J. L.
AU - Heston, L. L.
AU - Thibodeau, Stephen N
AU - Sommer, S. S.
PY - 1994
Y1 - 1994
N2 - The dystrophin gene, located at chromosome Xp21, was evaluated as a candidate gene in chronic schizophrenia in response to the report of a large family in which schizophrenia cosegregated with Becker muscular dystrophy [Zatz et al., 1991: Am J Hum Genet 49: A364; 1992: J Med Genet 30(2):131- 134]. Genomic DNA from 94 men with chronic schizophrenia was evaluated by Southern blot analysis using cDNA probes that span exons 1-59. No exonic deletions were identified. An unexpectedly high rate of polymorphism was calculated in this study and two novel polymorphisms were found, demonstrating the usefulness of the candidate gene approach even when results of the original study are negative.
AB - The dystrophin gene, located at chromosome Xp21, was evaluated as a candidate gene in chronic schizophrenia in response to the report of a large family in which schizophrenia cosegregated with Becker muscular dystrophy [Zatz et al., 1991: Am J Hum Genet 49: A364; 1992: J Med Genet 30(2):131- 134]. Genomic DNA from 94 men with chronic schizophrenia was evaluated by Southern blot analysis using cDNA probes that span exons 1-59. No exonic deletions were identified. An unexpectedly high rate of polymorphism was calculated in this study and two novel polymorphisms were found, demonstrating the usefulness of the candidate gene approach even when results of the original study are negative.
KW - dystrophin gene
KW - polymorphism
KW - polymorphism rate
KW - schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=0028147371&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028147371&partnerID=8YFLogxK
M3 - Article
C2 - 7909988
AN - SCOPUS:0028147371
VL - 54
SP - 1
EP - 4
JO - American Journal of Medical Genetics, Part A
JF - American Journal of Medical Genetics, Part A
SN - 0148-7299
IS - 1
ER -