Scientific Impact Recognition Award: Molecular breast imaging: A review of the Mayo Clinic experience

Carrie B Hruska, Judy C Boughey, Stephen W. Phillips, Deborah Rhodes, Dietlind L. Wahner-Roedler, Dana H. Whaley, Amy C Degnim, Michael K. O'Connor

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Background: Molecular breast imaging (MBI) depicts functional uptake of targeted radiotracers in the breast using dedicated gamma cameras. Methods: MBI studies were performed under several institutional protocols evaluating the use of MBI in screening and diagnosis. Results: By using a single-head system, sensitivity for breast cancer detection was 85% (57 of 67) overall and 29% for tumors 5 mm or less in diameter. Sensitivity improved to 91% (117 of 128) overall and 69% for tumors 5 mm or less using a dual-head system. In 650 high-risk patients undergoing breast cancer screening, MBI detected 7 cancers, 5 of which were missed on mammography. In 24 of 149 (16%) breast cancer patients MBI detected additional disease not seen on mammography. The sensitivity of MBI was 88% (83 of 94) for invasive ductal carcinoma, 79% (23 of 29) for invasive lobular carcinoma, and 89% (25 of 28) for ductal carcinoma in situ. Conclusions: MBI can detect invasive ductal carcinoma, ductal carcinoma in situ, and invasive lobular carcinoma. It has a promising role in evaluating the extent of disease and multifocal disease in the breast for surgical treatment planning.

Original languageEnglish (US)
Pages (from-to)470-476
Number of pages7
JournalAmerican Journal of Surgery
Volume196
Issue number4
DOIs
StatePublished - Oct 2008

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Keywords

  • Breast cancer
  • Detection
  • Molecular breast imaging
  • Scintimammography

ASJC Scopus subject areas

  • Surgery

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