Sarcopenia of male aging

Lisa S. Chow, K Sreekumaran Nair

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Sarcopenia is a common consequence of aging, with onset as early as the fourth decade. The decline in muscle strength is approximately 1% per year and is associated with loss of muscle mass and decreased muscle quality. At the cellular level, this loss of muscle function is associated with declines in muscle protein synthesis and mitochondrial capacity. Resistance strength training has the most substantive evidence in reversing sarcopenia, although aerobic exercise may also be beneficial. Both resistance and aerobic exercise enhance mixed muscle protein synthesis, although resistance training has a more profound stimulatory effect. It is likely that different exercise regimens may have distinctive effects on particular muscle proteins, suggesting the importance of variety in exercise. Although increased age and declining muscle function are associated with decreased testosterone levels in men, the role of testosterone supplementation remains controversial. Strong evidence exists for testosterone increasing muscle mass and muscle protein synthesis. Yet, a clear increase of muscle strength in elderly people by testosterone has not been observed, an observation vulnerable to confounding factors and experimental design. Much has been accomplished in studying the pathophysiology behind sarcopenia. Much still remains in altering its course.

Original languageEnglish (US)
Pages (from-to)833-852
Number of pages20
JournalEndocrinology and Metabolism Clinics of North America
Volume34
Issue number4
DOIs
StatePublished - Dec 2005

Fingerprint

Sarcopenia
Muscle Proteins
Muscle
Aging of materials
Resistance Training
Testosterone
Muscles
Exercise
Muscle Strength
Research Design
Observation
Design of experiments

ASJC Scopus subject areas

  • Endocrinology
  • Biochemistry

Cite this

Sarcopenia of male aging. / Chow, Lisa S.; Nair, K Sreekumaran.

In: Endocrinology and Metabolism Clinics of North America, Vol. 34, No. 4, 12.2005, p. 833-852.

Research output: Contribution to journalArticle

@article{7e7f3e8dff6c4270b32c0f492559fd0e,
title = "Sarcopenia of male aging",
abstract = "Sarcopenia is a common consequence of aging, with onset as early as the fourth decade. The decline in muscle strength is approximately 1{\%} per year and is associated with loss of muscle mass and decreased muscle quality. At the cellular level, this loss of muscle function is associated with declines in muscle protein synthesis and mitochondrial capacity. Resistance strength training has the most substantive evidence in reversing sarcopenia, although aerobic exercise may also be beneficial. Both resistance and aerobic exercise enhance mixed muscle protein synthesis, although resistance training has a more profound stimulatory effect. It is likely that different exercise regimens may have distinctive effects on particular muscle proteins, suggesting the importance of variety in exercise. Although increased age and declining muscle function are associated with decreased testosterone levels in men, the role of testosterone supplementation remains controversial. Strong evidence exists for testosterone increasing muscle mass and muscle protein synthesis. Yet, a clear increase of muscle strength in elderly people by testosterone has not been observed, an observation vulnerable to confounding factors and experimental design. Much has been accomplished in studying the pathophysiology behind sarcopenia. Much still remains in altering its course.",
author = "Chow, {Lisa S.} and Nair, {K Sreekumaran}",
year = "2005",
month = "12",
doi = "10.1016/j.ecl.2005.07.007",
language = "English (US)",
volume = "34",
pages = "833--852",
journal = "Endocrinology and Metabolism Clinics of North America",
issn = "0889-8529",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - Sarcopenia of male aging

AU - Chow, Lisa S.

AU - Nair, K Sreekumaran

PY - 2005/12

Y1 - 2005/12

N2 - Sarcopenia is a common consequence of aging, with onset as early as the fourth decade. The decline in muscle strength is approximately 1% per year and is associated with loss of muscle mass and decreased muscle quality. At the cellular level, this loss of muscle function is associated with declines in muscle protein synthesis and mitochondrial capacity. Resistance strength training has the most substantive evidence in reversing sarcopenia, although aerobic exercise may also be beneficial. Both resistance and aerobic exercise enhance mixed muscle protein synthesis, although resistance training has a more profound stimulatory effect. It is likely that different exercise regimens may have distinctive effects on particular muscle proteins, suggesting the importance of variety in exercise. Although increased age and declining muscle function are associated with decreased testosterone levels in men, the role of testosterone supplementation remains controversial. Strong evidence exists for testosterone increasing muscle mass and muscle protein synthesis. Yet, a clear increase of muscle strength in elderly people by testosterone has not been observed, an observation vulnerable to confounding factors and experimental design. Much has been accomplished in studying the pathophysiology behind sarcopenia. Much still remains in altering its course.

AB - Sarcopenia is a common consequence of aging, with onset as early as the fourth decade. The decline in muscle strength is approximately 1% per year and is associated with loss of muscle mass and decreased muscle quality. At the cellular level, this loss of muscle function is associated with declines in muscle protein synthesis and mitochondrial capacity. Resistance strength training has the most substantive evidence in reversing sarcopenia, although aerobic exercise may also be beneficial. Both resistance and aerobic exercise enhance mixed muscle protein synthesis, although resistance training has a more profound stimulatory effect. It is likely that different exercise regimens may have distinctive effects on particular muscle proteins, suggesting the importance of variety in exercise. Although increased age and declining muscle function are associated with decreased testosterone levels in men, the role of testosterone supplementation remains controversial. Strong evidence exists for testosterone increasing muscle mass and muscle protein synthesis. Yet, a clear increase of muscle strength in elderly people by testosterone has not been observed, an observation vulnerable to confounding factors and experimental design. Much has been accomplished in studying the pathophysiology behind sarcopenia. Much still remains in altering its course.

UR - http://www.scopus.com/inward/record.url?scp=27944456033&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27944456033&partnerID=8YFLogxK

U2 - 10.1016/j.ecl.2005.07.007

DO - 10.1016/j.ecl.2005.07.007

M3 - Article

VL - 34

SP - 833

EP - 852

JO - Endocrinology and Metabolism Clinics of North America

JF - Endocrinology and Metabolism Clinics of North America

SN - 0889-8529

IS - 4

ER -