Sarcoidosis following HIV infection: Evidence for CD4+ lymphocyte dependence

David G. Morris, Robert M. Jasmer, Laurence Huang, Michael Gotway, Stephen Nishimura, Talmadge E. King

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Background: The chronic granulomatous inflammation of sarcoidosis has been hypothesized to depend on the CD4+ T-helper lymphocyte. HIV infection, which depletes these cells, has been reported to attenuate the manifestations of sarcoidosis. Study objectives: We asked whether the development of symptomatic sarcoidosis in the context of preexisting HIV infection was dependent on the CD4+ lymphocyte count. Design: We performed a retrospective standardized chart review of all patients who developed granulomatous inflammation following HIV infection at an urban academic referral center. Measurements: We identified seven patients with sarcoidosis within this cohort and compared their CD4+ lymphocyte count to that in a cohort of 16 patients in whom similar granulomatous inflammation was found but who did not have sarcoidosis. We then compared our cases to all reported cases using a systematic literature review. Results: The CD4+ lymphocyte count was > 200 cells/μL in all of our patients with HIV infection when they developed subsequent sarcoidosis. In contrast, specific etiologies for granulomatous inflammation were found in all 10 HIV-infected patients who presented with granulomatous inflammation and a CD4+ lymphocyte count of < 200 cells/μL, with infectious etiologies found in 8 patients. Similarly, there was relative preservation of the CD4+ lymphocyte count in previously reported cases, with 14 of 19 patients (74%) having an absolute CD4+ lymphocyte count of > 200 cells/μL. Conclusions: We conclude that the development of the chronic granulomatous inflammation of sarcoidosis appears to depend on the preservation or restoration of the peripheral CD4+ lymphocyte count and that in most cases the CD4+ lymphocyte count exceeds 200 cells/μL. Furthermore, alternative specific etiologies of granulomatous inflammation are generally identifiable in HIV-infected patients with peripheral CD4+ lymphocyte counts of < 200 cells/μL.

Original languageEnglish (US)
Pages (from-to)929-935
Number of pages7
JournalChest
Volume124
Issue number3
DOIs
StatePublished - Sep 1 2003
Externally publishedYes

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Sarcoidosis
CD4 Lymphocyte Count
HIV Infections
Lymphocytes
Inflammation
HIV
Helper-Inducer T-Lymphocytes
Referral and Consultation

Keywords

  • HIV infection
  • Immune restoration
  • Sarcoidosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Morris, D. G., Jasmer, R. M., Huang, L., Gotway, M., Nishimura, S., & King, T. E. (2003). Sarcoidosis following HIV infection: Evidence for CD4+ lymphocyte dependence. Chest, 124(3), 929-935. https://doi.org/10.1378/chest.124.3.929

Sarcoidosis following HIV infection : Evidence for CD4+ lymphocyte dependence. / Morris, David G.; Jasmer, Robert M.; Huang, Laurence; Gotway, Michael; Nishimura, Stephen; King, Talmadge E.

In: Chest, Vol. 124, No. 3, 01.09.2003, p. 929-935.

Research output: Contribution to journalArticle

Morris, DG, Jasmer, RM, Huang, L, Gotway, M, Nishimura, S & King, TE 2003, 'Sarcoidosis following HIV infection: Evidence for CD4+ lymphocyte dependence', Chest, vol. 124, no. 3, pp. 929-935. https://doi.org/10.1378/chest.124.3.929
Morris, David G. ; Jasmer, Robert M. ; Huang, Laurence ; Gotway, Michael ; Nishimura, Stephen ; King, Talmadge E. / Sarcoidosis following HIV infection : Evidence for CD4+ lymphocyte dependence. In: Chest. 2003 ; Vol. 124, No. 3. pp. 929-935.
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abstract = "Background: The chronic granulomatous inflammation of sarcoidosis has been hypothesized to depend on the CD4+ T-helper lymphocyte. HIV infection, which depletes these cells, has been reported to attenuate the manifestations of sarcoidosis. Study objectives: We asked whether the development of symptomatic sarcoidosis in the context of preexisting HIV infection was dependent on the CD4+ lymphocyte count. Design: We performed a retrospective standardized chart review of all patients who developed granulomatous inflammation following HIV infection at an urban academic referral center. Measurements: We identified seven patients with sarcoidosis within this cohort and compared their CD4+ lymphocyte count to that in a cohort of 16 patients in whom similar granulomatous inflammation was found but who did not have sarcoidosis. We then compared our cases to all reported cases using a systematic literature review. Results: The CD4+ lymphocyte count was > 200 cells/μL in all of our patients with HIV infection when they developed subsequent sarcoidosis. In contrast, specific etiologies for granulomatous inflammation were found in all 10 HIV-infected patients who presented with granulomatous inflammation and a CD4+ lymphocyte count of < 200 cells/μL, with infectious etiologies found in 8 patients. Similarly, there was relative preservation of the CD4+ lymphocyte count in previously reported cases, with 14 of 19 patients (74{\%}) having an absolute CD4+ lymphocyte count of > 200 cells/μL. Conclusions: We conclude that the development of the chronic granulomatous inflammation of sarcoidosis appears to depend on the preservation or restoration of the peripheral CD4+ lymphocyte count and that in most cases the CD4+ lymphocyte count exceeds 200 cells/μL. Furthermore, alternative specific etiologies of granulomatous inflammation are generally identifiable in HIV-infected patients with peripheral CD4+ lymphocyte counts of < 200 cells/μL.",
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