Safety and efficacy of buprenorphine for analgesia in laboratory mice and rats

Michael Guarnieri, Cory Brayton, Louis Detolla, Nadine Forbes-Mcbean, Rachel Sarabia Estrada, Patricia Zadnik

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

Buprenorphine is a long-acting opiate with a high therapeutic index. The authors review the pharmacology, toxicity, analgesic effects and delivery of buprenorphine for use in laboratory mice and rats. Buprenorphine-based analgesic therapy has a substantial record of safety, and there is growing evidence of its effectiveness for treating post-operative pain. Nonetheless, more research is needed to determine optimal delivery systems and analgesic regimens for pain therapy in laboratory animals.

Original languageEnglish (US)
Pages (from-to)337-343
Number of pages7
JournalLab Animal
Volume41
Issue number11
DOIs
StatePublished - Nov 2012
Externally publishedYes

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buprenorphine
Buprenorphine
analgesia
Analgesia
Analgesics
analgesics
Safety
Opiate Alkaloids
pain
rats
mice
therapy animals
Pain
therapeutics
analgesic effect
Laboratory Animals
pharmacology
laboratory animals
Therapeutics
Pharmacology

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Guarnieri, M., Brayton, C., Detolla, L., Forbes-Mcbean, N., Sarabia Estrada, R., & Zadnik, P. (2012). Safety and efficacy of buprenorphine for analgesia in laboratory mice and rats. Lab Animal, 41(11), 337-343. https://doi.org/10.1038/laban.152

Safety and efficacy of buprenorphine for analgesia in laboratory mice and rats. / Guarnieri, Michael; Brayton, Cory; Detolla, Louis; Forbes-Mcbean, Nadine; Sarabia Estrada, Rachel; Zadnik, Patricia.

In: Lab Animal, Vol. 41, No. 11, 11.2012, p. 337-343.

Research output: Contribution to journalReview article

Guarnieri, M, Brayton, C, Detolla, L, Forbes-Mcbean, N, Sarabia Estrada, R & Zadnik, P 2012, 'Safety and efficacy of buprenorphine for analgesia in laboratory mice and rats', Lab Animal, vol. 41, no. 11, pp. 337-343. https://doi.org/10.1038/laban.152
Guarnieri, Michael ; Brayton, Cory ; Detolla, Louis ; Forbes-Mcbean, Nadine ; Sarabia Estrada, Rachel ; Zadnik, Patricia. / Safety and efficacy of buprenorphine for analgesia in laboratory mice and rats. In: Lab Animal. 2012 ; Vol. 41, No. 11. pp. 337-343.
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