TY - JOUR
T1 - Safety and efficacy of buprenorphine for analgesia in laboratory mice and rats
AU - Guarnieri, Michael
AU - Brayton, Cory
AU - Detolla, Louis
AU - Forbes-Mcbean, Nadine
AU - Sarabia-Estrada, Rachel
AU - Zadnik, Patricia
N1 - Funding Information:
The authors declare competing financial interests. Funding to support this work was obtained from the biotechnology and economic development programs of maryland Technology Development Corporation (TeDCo) and maryland Industrial Partnerships (mIPS) and from bamvet Laboratories, Inc. P.Z. is a paid consultant for bamvet and is supported by a Johns Hopkins medical research Fellowship. m.G. holds a significant financial interest in bamvet.
PY - 2012/11
Y1 - 2012/11
N2 - Buprenorphine is a long-acting opiate with a high therapeutic index. The authors review the pharmacology, toxicity, analgesic effects and delivery of buprenorphine for use in laboratory mice and rats. Buprenorphine-based analgesic therapy has a substantial record of safety, and there is growing evidence of its effectiveness for treating post-operative pain. Nonetheless, more research is needed to determine optimal delivery systems and analgesic regimens for pain therapy in laboratory animals.
AB - Buprenorphine is a long-acting opiate with a high therapeutic index. The authors review the pharmacology, toxicity, analgesic effects and delivery of buprenorphine for use in laboratory mice and rats. Buprenorphine-based analgesic therapy has a substantial record of safety, and there is growing evidence of its effectiveness for treating post-operative pain. Nonetheless, more research is needed to determine optimal delivery systems and analgesic regimens for pain therapy in laboratory animals.
UR - http://www.scopus.com/inward/record.url?scp=84867755115&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84867755115&partnerID=8YFLogxK
U2 - 10.1038/laban.152
DO - 10.1038/laban.152
M3 - Review article
C2 - 23079917
AN - SCOPUS:84867755115
SN - 0093-7355
VL - 41
SP - 337
EP - 343
JO - Lab Animal
JF - Lab Animal
IS - 11
ER -