Safety and efficacy of buprenorphine for analgesia in laboratory mice and rats

Michael Guarnieri, Cory Brayton, Louis Detolla, Nadine Forbes-Mcbean, Rachel Sarabia-Estrada, Patricia Zadnik

Research output: Contribution to journalReview article

36 Scopus citations

Abstract

Buprenorphine is a long-acting opiate with a high therapeutic index. The authors review the pharmacology, toxicity, analgesic effects and delivery of buprenorphine for use in laboratory mice and rats. Buprenorphine-based analgesic therapy has a substantial record of safety, and there is growing evidence of its effectiveness for treating post-operative pain. Nonetheless, more research is needed to determine optimal delivery systems and analgesic regimens for pain therapy in laboratory animals.

Original languageEnglish (US)
Pages (from-to)337-343
Number of pages7
JournalLab Animal
Volume41
Issue number11
DOIs
StatePublished - Nov 1 2012

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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    Guarnieri, M., Brayton, C., Detolla, L., Forbes-Mcbean, N., Sarabia-Estrada, R., & Zadnik, P. (2012). Safety and efficacy of buprenorphine for analgesia in laboratory mice and rats. Lab Animal, 41(11), 337-343. https://doi.org/10.1038/laban.152