Abstract
Cancer tissue engineering has remained challenging due to the limitations of the conventional biofabrication techniques to model the complex tumor microenvironment. Here, the utilization of a sacrificial bioprinting strategy is reported to generate the biomimetic mammary duct-like structure within a hydrogel matrix, which is further populated with breast cancer cells, to model the genesis of ductal carcinoma and its subsequent outward invasion. This bioprinted mammary ductal carcinoma model provides a proof-of-concept demonstration of the value of using the sacrificial bioprinting technique for engineering biologically relevant cancer models, which may be possibly extended to other cancer types where duct-like structures are involved.
Original language | English (US) |
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Article number | 1700703 |
Journal | Biotechnology Journal |
Volume | 14 |
Issue number | 10 |
DOIs | |
State | Published - Oct 1 2019 |
Keywords
- bioprinting
- breast cancer
- cancer model
- ductal carcinoma
- hydrogel
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology
- Molecular Medicine