Sacrificial Bioprinting of a Mammary Ductal Carcinoma Model

Margaux Duchamp, Tingting Liu, Anne M. van Genderen, Vanessa Kappings, Rahmi Oklu, Leif W. Ellisen, Yu Shrike Zhang

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Cancer tissue engineering has remained challenging due to the limitations of the conventional biofabrication techniques to model the complex tumor microenvironment. Here, the utilization of a sacrificial bioprinting strategy is reported to generate the biomimetic mammary duct-like structure within a hydrogel matrix, which is further populated with breast cancer cells, to model the genesis of ductal carcinoma and its subsequent outward invasion. This bioprinted mammary ductal carcinoma model provides a proof-of-concept demonstration of the value of using the sacrificial bioprinting technique for engineering biologically relevant cancer models, which may be possibly extended to other cancer types where duct-like structures are involved.

Original languageEnglish (US)
Article number1700703
JournalBiotechnology Journal
Volume14
Issue number10
DOIs
StatePublished - Oct 1 2019

Keywords

  • bioprinting
  • breast cancer
  • cancer model
  • ductal carcinoma
  • hydrogel

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Molecular Medicine

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