TY - JOUR
T1 - Routes for drug delivery to the retina
T2 - Topical, transscleral, suprachoroidal and intravitreal gas phase delivery
AU - Yamada, Norihiro
AU - Olsen, Timothy W.
N1 - Publisher Copyright:
© 2016 S. Karger AG, Basel.
PY - 2015
Y1 - 2015
N2 - Local drug delivery to the posterior segment, particularly the macula, represents a significant challenge. In this chapter, we review current challenges, barriers and limitations. Due to the local drug delivery to the retina and macula, systemic side effects are limited. In this chapter, we also discuss the historical approaches, key aspects of ideal drug delivery systems, the use of animal models to study pharmacokinetics, and the principles of transscleral, suprachoroidal and gas phase drug delivery.
AB - Local drug delivery to the posterior segment, particularly the macula, represents a significant challenge. In this chapter, we review current challenges, barriers and limitations. Due to the local drug delivery to the retina and macula, systemic side effects are limited. In this chapter, we also discuss the historical approaches, key aspects of ideal drug delivery systems, the use of animal models to study pharmacokinetics, and the principles of transscleral, suprachoroidal and gas phase drug delivery.
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U2 - 10.1159/000431193
DO - 10.1159/000431193
M3 - Review article
C2 - 26501685
AN - SCOPUS:84947276475
SN - 0250-3751
VL - 55
SP - 71
EP - 83
JO - Developments in ophthalmology
JF - Developments in ophthalmology
ER -