Role of the microbiota and antibiotics in primary sclerosing cholangitis

James H. Tabibian, Jayant A. Talwalkar, Keith D. Lindor

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations

Abstract

Primary sclerosing cholangitis (PSC) is an idiopathic, progressive, cholestatic liver disease with considerable morbidity and mortality and no established pharmacotherapy. In addition to the long-recognized association between PSC and inflammatory bowel disease, several lines of preclinical and clinical evidence implicate the microbiota in the etiopathogenesis of PSC. Here we provide a concise review of these data which, taken together, support further investigation of the role of the microbiota and antibiotics in PSC as potential avenues toward elucidating safe and effective pharmacotherapy for patients afflicted by this illness.

Original languageEnglish (US)
Article number389537
JournalBioMed Research International
Volume2013
DOIs
StatePublished - 2013

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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