Role of Operative Therapy in Non-cirrhotic Patients with Metastatic Hepatocellular Carcinoma

Victor Zaydfudim, Rory L. Smoot, Clancy J. Clark, Michael L. Kendrick, Florencia G. Que, Michael B. Farnell, David M. Nagorney

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Introduction: We investigated the role of operative therapy in non-cirrhotic patients who developed metastatic hepatocellular carcinoma (HCC). Methods: This retrospective cohort study included consecutive non-cirrhotic patients with metastatic HCC after a prior hepatectomy treated between 1990 and 2009. Patients were stratified by operative therapy (resection, ablation, transcatheter therapy). Kaplan-Meier analyses with log-rank comparisons tested effects of operative therapy on overall survival (OS) and progression-free survival (PFS). Results: Of 195 non-cirrhotic patients treated for HCC during the study period, 98 [median age 65, interquartile range (IQR) 53-71; 55 % male] subsequently developed metastatic HCC (55 intrahepatic only). Median time to development of metastases after the index operation was 10 months (IQR 5-20 months); median number of metastases was 3 (IQR 2-7). Half of these patients (n = 50) underwent operative treatment of metastases; 20 (40 %) underwent metastasectomy, 18 (36 %) ablation, and 12 (24 %) transcatheter therapy. Operative therapy was associated with improved OS (p < 0.001). Resection or ablation was associated with improved PFS and OS compared to transcatheter therapy (all p ≤ 0.006). Nine patients (seven resection, two ablation) are disease free at a median of 50 months (IQR 24-80 months) posttreatment. Conclusions: Resection and ablation are associated with an improved PFS and long-term OS and should be considered in select patients with metastatic HCC.

Original languageEnglish (US)
Pages (from-to)1516-1523
Number of pages8
JournalJournal of Gastrointestinal Surgery
Volume16
Issue number8
DOIs
StatePublished - Aug 1 2012

Keywords

  • Ablation
  • HCC
  • Hepatocellular carcinoma
  • Metastasectomy
  • Metastasis
  • Outcome
  • Recurrence
  • Resection
  • Sorafenib

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

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