Role of hormonal changes in the pathogenesis of osteoporosis in men

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

It is clear that age-related changes in sex-steroid production and availability likely play an important role in mediating bone loss in elderly men. Estrogen appears to be particularly important in regulating bone resorption, probably on cancellous and endocortical surfaces, whereas testosterone may have its major effect on periosteal surfaces. There also appears to be a significant role for age-related changes in growth hormone and IGF-I production in mediating age-related bone loss, in part through possible effects of IGF-I on SHBG production, resulting in alterations in sex steroid bioavailability. Perhaps somewhat surprisingly, the hormonal changes in young and middle-aged men with idiopathic osteoporosis appear to be paralleling those seen in aging men, although only a small number of men with idiopathic osteoporosis have been studied in detail. A more complete understanding of the hormonal factors leading to bone loss in both groups of men is likely to lead not only to insights on the mechanisms of sex-steroid action on bone, but also to more rational, mechanism-based therapeutic approaches.

Original languageEnglish (US)
Pages (from-to)110-113
Number of pages4
JournalCalcified Tissue International
Volume75
Issue number2
DOIs
StatePublished - Aug 1 2004

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

Fingerprint Dive into the research topics of 'Role of hormonal changes in the pathogenesis of osteoporosis in men'. Together they form a unique fingerprint.

Cite this