Role of diastolic function indices in the risk stratification of patients with mixed aortic valve disease

Alexander Egbe, Arooj R. Khan, Amber Boler, Sameh M. Said, Jeffrey B. Geske, William R. Miranda, Emmanuel Akintoye, Heidi M. Connolly, Carole A. Warnes, Jae Kuen Oh

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Abstract

Aims Determine the role of diastolic function indices in pre-operative and post-operative risk stratification in patients with moderate mixed aortic valve disease (MAVD). Methods and results A retrospective study was conducted of asymptomatic patients with moderate MAVD (a combination of moderate aortic stenosis and moderate aortic regurgitation) and an ejection fraction of 50% or more who were followed up at Mayo Clinic from 1 January 2004, to 31 December 2013. A pre-requisite for inclusion in the study was assessment of diastolic function involving at least three of the following indices: Tissue Doppler early diastolic velocity (e′), mitral inflow early velocity (E), tricuspid regurgitation velocity, and left atrial volume index. Primary endpoints were aortic valve replacement (AVR) or cardiac death while secondary endpoints were cardiovascular adverse events (CAEs) after AVR. We defined CAEs as stroke, heart failure hospitalization, severe left ventricular dysfunction, and cardiac death. There were 214 patients (age 61 ± 8 years, men 146 [68%]) followed for 6.1 ± 2.3 years during which 162 (76%) AVRs and 11 (5%) cardiac deaths occurred. The multivariable risk factors for cardiac death or AVR were relative wall thickness (RWT) > 0.42 [hazard ratio (HR), 1.88 [95% CI, 1.28-2.59]; P = 0.001] and average E/e′ >14 (HR, 1.94 [95% CI, 1.29-3.01]; P = 0.02). Freedom from CAE after AVR was significantly lower in the patients with baseline RWT >0.42 or mean E/e′ >14 than the other patients: 79% (95% CI 74-83%) vs. 94% (95% CI 89-98%) at 3 years (P = 0.03). Conclusion The presence of RWT >0.42 or E/e′ >14 identifies a high-risk patient subset whose risk for cardiovascular morbidities persists even after AVR.

Original languageEnglish (US)
Pages (from-to)668-674
Number of pages7
JournalEuropean Heart Journal Cardiovascular Imaging
Volume19
Issue number6
DOIs
StatePublished - Jun 1 2018

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Aortic Diseases
Aortic Valve
Tricuspid Valve Insufficiency
Aortic Valve Insufficiency
Heart Valves
Aortic Valve Stenosis
Left Ventricular Dysfunction
Hospitalization
Heart Failure
Retrospective Studies
Stroke
Morbidity

Keywords

  • aorta
  • diastole
  • regurgitation
  • stenosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Role of diastolic function indices in the risk stratification of patients with mixed aortic valve disease. / Egbe, Alexander; Khan, Arooj R.; Boler, Amber; Said, Sameh M.; Geske, Jeffrey B.; Miranda, William R.; Akintoye, Emmanuel; Connolly, Heidi M.; Warnes, Carole A.; Oh, Jae Kuen.

In: European Heart Journal Cardiovascular Imaging, Vol. 19, No. 6, 01.06.2018, p. 668-674.

Research output: Contribution to journalArticle

Egbe, A, Khan, AR, Boler, A, Said, SM, Geske, JB, Miranda, WR, Akintoye, E, Connolly, HM, Warnes, CA & Oh, JK 2018, 'Role of diastolic function indices in the risk stratification of patients with mixed aortic valve disease', European Heart Journal Cardiovascular Imaging, vol. 19, no. 6, pp. 668-674. https://doi.org/10.1093/ehjci/jex148
Egbe, Alexander ; Khan, Arooj R. ; Boler, Amber ; Said, Sameh M. ; Geske, Jeffrey B. ; Miranda, William R. ; Akintoye, Emmanuel ; Connolly, Heidi M. ; Warnes, Carole A. ; Oh, Jae Kuen. / Role of diastolic function indices in the risk stratification of patients with mixed aortic valve disease. In: European Heart Journal Cardiovascular Imaging. 2018 ; Vol. 19, No. 6. pp. 668-674.
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abstract = "Aims Determine the role of diastolic function indices in pre-operative and post-operative risk stratification in patients with moderate mixed aortic valve disease (MAVD). Methods and results A retrospective study was conducted of asymptomatic patients with moderate MAVD (a combination of moderate aortic stenosis and moderate aortic regurgitation) and an ejection fraction of 50{\%} or more who were followed up at Mayo Clinic from 1 January 2004, to 31 December 2013. A pre-requisite for inclusion in the study was assessment of diastolic function involving at least three of the following indices: Tissue Doppler early diastolic velocity (e′), mitral inflow early velocity (E), tricuspid regurgitation velocity, and left atrial volume index. Primary endpoints were aortic valve replacement (AVR) or cardiac death while secondary endpoints were cardiovascular adverse events (CAEs) after AVR. We defined CAEs as stroke, heart failure hospitalization, severe left ventricular dysfunction, and cardiac death. There were 214 patients (age 61 ± 8 years, men 146 [68{\%}]) followed for 6.1 ± 2.3 years during which 162 (76{\%}) AVRs and 11 (5{\%}) cardiac deaths occurred. The multivariable risk factors for cardiac death or AVR were relative wall thickness (RWT) > 0.42 [hazard ratio (HR), 1.88 [95{\%} CI, 1.28-2.59]; P = 0.001] and average E/e′ >14 (HR, 1.94 [95{\%} CI, 1.29-3.01]; P = 0.02). Freedom from CAE after AVR was significantly lower in the patients with baseline RWT >0.42 or mean E/e′ >14 than the other patients: 79{\%} (95{\%} CI 74-83{\%}) vs. 94{\%} (95{\%} CI 89-98{\%}) at 3 years (P = 0.03). Conclusion The presence of RWT >0.42 or E/e′ >14 identifies a high-risk patient subset whose risk for cardiovascular morbidities persists even after AVR.",
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T1 - Role of diastolic function indices in the risk stratification of patients with mixed aortic valve disease

AU - Egbe, Alexander

AU - Khan, Arooj R.

AU - Boler, Amber

AU - Said, Sameh M.

AU - Geske, Jeffrey B.

AU - Miranda, William R.

AU - Akintoye, Emmanuel

AU - Connolly, Heidi M.

AU - Warnes, Carole A.

AU - Oh, Jae Kuen

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N2 - Aims Determine the role of diastolic function indices in pre-operative and post-operative risk stratification in patients with moderate mixed aortic valve disease (MAVD). Methods and results A retrospective study was conducted of asymptomatic patients with moderate MAVD (a combination of moderate aortic stenosis and moderate aortic regurgitation) and an ejection fraction of 50% or more who were followed up at Mayo Clinic from 1 January 2004, to 31 December 2013. A pre-requisite for inclusion in the study was assessment of diastolic function involving at least three of the following indices: Tissue Doppler early diastolic velocity (e′), mitral inflow early velocity (E), tricuspid regurgitation velocity, and left atrial volume index. Primary endpoints were aortic valve replacement (AVR) or cardiac death while secondary endpoints were cardiovascular adverse events (CAEs) after AVR. We defined CAEs as stroke, heart failure hospitalization, severe left ventricular dysfunction, and cardiac death. There were 214 patients (age 61 ± 8 years, men 146 [68%]) followed for 6.1 ± 2.3 years during which 162 (76%) AVRs and 11 (5%) cardiac deaths occurred. The multivariable risk factors for cardiac death or AVR were relative wall thickness (RWT) > 0.42 [hazard ratio (HR), 1.88 [95% CI, 1.28-2.59]; P = 0.001] and average E/e′ >14 (HR, 1.94 [95% CI, 1.29-3.01]; P = 0.02). Freedom from CAE after AVR was significantly lower in the patients with baseline RWT >0.42 or mean E/e′ >14 than the other patients: 79% (95% CI 74-83%) vs. 94% (95% CI 89-98%) at 3 years (P = 0.03). Conclusion The presence of RWT >0.42 or E/e′ >14 identifies a high-risk patient subset whose risk for cardiovascular morbidities persists even after AVR.

AB - Aims Determine the role of diastolic function indices in pre-operative and post-operative risk stratification in patients with moderate mixed aortic valve disease (MAVD). Methods and results A retrospective study was conducted of asymptomatic patients with moderate MAVD (a combination of moderate aortic stenosis and moderate aortic regurgitation) and an ejection fraction of 50% or more who were followed up at Mayo Clinic from 1 January 2004, to 31 December 2013. A pre-requisite for inclusion in the study was assessment of diastolic function involving at least three of the following indices: Tissue Doppler early diastolic velocity (e′), mitral inflow early velocity (E), tricuspid regurgitation velocity, and left atrial volume index. Primary endpoints were aortic valve replacement (AVR) or cardiac death while secondary endpoints were cardiovascular adverse events (CAEs) after AVR. We defined CAEs as stroke, heart failure hospitalization, severe left ventricular dysfunction, and cardiac death. There were 214 patients (age 61 ± 8 years, men 146 [68%]) followed for 6.1 ± 2.3 years during which 162 (76%) AVRs and 11 (5%) cardiac deaths occurred. The multivariable risk factors for cardiac death or AVR were relative wall thickness (RWT) > 0.42 [hazard ratio (HR), 1.88 [95% CI, 1.28-2.59]; P = 0.001] and average E/e′ >14 (HR, 1.94 [95% CI, 1.29-3.01]; P = 0.02). Freedom from CAE after AVR was significantly lower in the patients with baseline RWT >0.42 or mean E/e′ >14 than the other patients: 79% (95% CI 74-83%) vs. 94% (95% CI 89-98%) at 3 years (P = 0.03). Conclusion The presence of RWT >0.42 or E/e′ >14 identifies a high-risk patient subset whose risk for cardiovascular morbidities persists even after AVR.

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