Role of cyclooxygenase-2 in colorectal cancer

Frank A Sinicrope, Sharlene Gill

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

Cyclooxygenase-2 (COX-2) is an inducible enzyme that regulates prostaglandin synthesis and is overexpressed at sites of inflammation and in several epithelial cancers. Recently, a causal link for COX-2 in epithelial tumorigenesis was shown in genetically-manipulated animal models of colon and breast carcinoma. Data indicate that COX-2 is involved in the regulation of apoptosis, angiogenesis, and tumor cell invasiveness, which appear to contribute to its effects on tumorigenesis. Multiple studies have shown that nonselective COX and selective COX-2 inhibitors effectively prevent experimental colon cancer. Furthermore, sulindac and the selective COX-2 inhibitor celecoxib were shown to regress colorectal polyps in patients with familial adenomatous polyposis. Although the exact anti-tumor mechanisms of these agents await further study, data indicate that both COX-dependent and COX-independent mechanisms may be important. In this review, the association between COX-2 and colorectal tumorigenesis and potential mechanisms of this effect are discussed. Additionally, evidence supporting the role of NSAIDs and selective COX-2 inhibitors for the prevention and treatment of human colorectal cancer is reviewed.

Original languageEnglish (US)
Pages (from-to)63-75
Number of pages13
JournalCancer and Metastasis Reviews
Volume23
Issue number1-2
DOIs
StatePublished - Jan 2004

Fingerprint

Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Colorectal Neoplasms
Carcinogenesis
Celecoxib
Sulindac
Neoplasms
Adenomatous Polyposis Coli
Non-Steroidal Anti-Inflammatory Agents
Polyps
Colonic Neoplasms
Prostaglandins
Colon
Animal Models
Apoptosis
Breast Neoplasms
Inflammation
Enzymes
Therapeutics

Keywords

  • Colorectal cancer
  • Coxibs
  • Cyclooxygenase-2
  • NSAIDs
  • Tumorigenesis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Role of cyclooxygenase-2 in colorectal cancer. / Sinicrope, Frank A; Gill, Sharlene.

In: Cancer and Metastasis Reviews, Vol. 23, No. 1-2, 01.2004, p. 63-75.

Research output: Contribution to journalArticle

Sinicrope, Frank A ; Gill, Sharlene. / Role of cyclooxygenase-2 in colorectal cancer. In: Cancer and Metastasis Reviews. 2004 ; Vol. 23, No. 1-2. pp. 63-75.
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