Risks of colorectal and other cancers after endometrial cancer for women with lynch syndrome

Aung Ko Win, Noralane Morey Lindor, Ingrid Winship, Katherine M. Tucker, Daniel D. Buchanan, Joanne P. Young, Christophe Rosty, Barbara Leggett, Graham G. Giles, Jack Goldblatt, Finlay A. MacRae, Susan Parry, Matthew F. Kalady, John A. Baron, Dennis J. Ahnen, Loic Le Marchand, Steven Gallinger, Robert W. Haile, Polly A. Newcomb, John L. HopperMark A. Jenkins

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Abstract

Background Lynch syndrome is an autosomal dominantly inherited disorder caused by germline mutations in DNA mismatch repair (MMR) genes. Previous studies have shown that MMR gene mutation carriers are at increased risk of colorectal, endometrial, and several other cancers following an initial diagnosis of colorectal cancer. We estimated cancer risks following an endometrial cancer diagnosis for women carrying MMR gene mutations. Methods We obtained data from the Colon Cancer Family Registry for a cohort of 127 women who had a diagnosis of endometrial cancer and who carried a mutation in one of four MMR genes (30 carried a mutation in MLH1, 72 in MSH2, 22 in MSH6, and 3 in PMS2). We used the Kaplan-Meier method to estimate 10- and 20-year cumulative risks for each cancer. We estimated the age-, country-, and calendar period-specific standardized incidence ratios (SIRs) for each cancer, compared with the general population. Results Following endometrial cancer, women carrying MMR gene mutations had the following 20-year risks of other cancer cancers: colorectal cancer (48%, 95% confidence interval [CI] = 35% to 62%); cancer of the kidney, renal pelvis, or ureter (11%, 95% CI = 3% to 20%); urinary bladder cancer (9%, 95% CI = 2% to 17%); and breast cancer (11%, 95% CI = 4% to 19%). Compared with the general population, these women were at statistically significantly elevated risks of colorectal cancer (SIR = 39.9, 95% CI = 27.2 to 58.3), cancer of the kidney, renal pelvis, or ureter (SIR = 28.3, 95% CI = 11.9 to 48.6), urinary bladder cancer (SIR = 24.3, 95% CI = 8.56 to 42.9), and breast cancer (SIR = 2.51, 95% CI = 1.17 to 4.14). Conclusions Women with Lynch syndrome who are diagnosed with endometrial cancer have increased risks of several cancers, including breast cancer.

Original languageEnglish (US)
Pages (from-to)274-279
Number of pages6
JournalJournal of the National Cancer Institute
Volume105
Issue number4
DOIs
StatePublished - Feb 20 2013

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Hereditary Nonpolyposis Colorectal Neoplasms
Endometrial Neoplasms
Colorectal Neoplasms
DNA Mismatch Repair
Confidence Intervals
Kidney Pelvis
Mutation
Incidence
Breast Neoplasms
Neoplasms
Kidney Neoplasms
Genes
Ureter
Urinary Bladder Neoplasms
Germ-Line Mutation
Colonic Neoplasms
Population
Registries

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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Risks of colorectal and other cancers after endometrial cancer for women with lynch syndrome. / Win, Aung Ko; Lindor, Noralane Morey; Winship, Ingrid; Tucker, Katherine M.; Buchanan, Daniel D.; Young, Joanne P.; Rosty, Christophe; Leggett, Barbara; Giles, Graham G.; Goldblatt, Jack; MacRae, Finlay A.; Parry, Susan; Kalady, Matthew F.; Baron, John A.; Ahnen, Dennis J.; Marchand, Loic Le; Gallinger, Steven; Haile, Robert W.; Newcomb, Polly A.; Hopper, John L.; Jenkins, Mark A.

In: Journal of the National Cancer Institute, Vol. 105, No. 4, 20.02.2013, p. 274-279.

Research output: Contribution to journalArticle

Win, AK, Lindor, NM, Winship, I, Tucker, KM, Buchanan, DD, Young, JP, Rosty, C, Leggett, B, Giles, GG, Goldblatt, J, MacRae, FA, Parry, S, Kalady, MF, Baron, JA, Ahnen, DJ, Marchand, LL, Gallinger, S, Haile, RW, Newcomb, PA, Hopper, JL & Jenkins, MA 2013, 'Risks of colorectal and other cancers after endometrial cancer for women with lynch syndrome', Journal of the National Cancer Institute, vol. 105, no. 4, pp. 274-279. https://doi.org/10.1093/jnci/djs525
Win, Aung Ko ; Lindor, Noralane Morey ; Winship, Ingrid ; Tucker, Katherine M. ; Buchanan, Daniel D. ; Young, Joanne P. ; Rosty, Christophe ; Leggett, Barbara ; Giles, Graham G. ; Goldblatt, Jack ; MacRae, Finlay A. ; Parry, Susan ; Kalady, Matthew F. ; Baron, John A. ; Ahnen, Dennis J. ; Marchand, Loic Le ; Gallinger, Steven ; Haile, Robert W. ; Newcomb, Polly A. ; Hopper, John L. ; Jenkins, Mark A. / Risks of colorectal and other cancers after endometrial cancer for women with lynch syndrome. In: Journal of the National Cancer Institute. 2013 ; Vol. 105, No. 4. pp. 274-279.
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title = "Risks of colorectal and other cancers after endometrial cancer for women with lynch syndrome",
abstract = "Background Lynch syndrome is an autosomal dominantly inherited disorder caused by germline mutations in DNA mismatch repair (MMR) genes. Previous studies have shown that MMR gene mutation carriers are at increased risk of colorectal, endometrial, and several other cancers following an initial diagnosis of colorectal cancer. We estimated cancer risks following an endometrial cancer diagnosis for women carrying MMR gene mutations. Methods We obtained data from the Colon Cancer Family Registry for a cohort of 127 women who had a diagnosis of endometrial cancer and who carried a mutation in one of four MMR genes (30 carried a mutation in MLH1, 72 in MSH2, 22 in MSH6, and 3 in PMS2). We used the Kaplan-Meier method to estimate 10- and 20-year cumulative risks for each cancer. We estimated the age-, country-, and calendar period-specific standardized incidence ratios (SIRs) for each cancer, compared with the general population. Results Following endometrial cancer, women carrying MMR gene mutations had the following 20-year risks of other cancer cancers: colorectal cancer (48{\%}, 95{\%} confidence interval [CI] = 35{\%} to 62{\%}); cancer of the kidney, renal pelvis, or ureter (11{\%}, 95{\%} CI = 3{\%} to 20{\%}); urinary bladder cancer (9{\%}, 95{\%} CI = 2{\%} to 17{\%}); and breast cancer (11{\%}, 95{\%} CI = 4{\%} to 19{\%}). Compared with the general population, these women were at statistically significantly elevated risks of colorectal cancer (SIR = 39.9, 95{\%} CI = 27.2 to 58.3), cancer of the kidney, renal pelvis, or ureter (SIR = 28.3, 95{\%} CI = 11.9 to 48.6), urinary bladder cancer (SIR = 24.3, 95{\%} CI = 8.56 to 42.9), and breast cancer (SIR = 2.51, 95{\%} CI = 1.17 to 4.14). Conclusions Women with Lynch syndrome who are diagnosed with endometrial cancer have increased risks of several cancers, including breast cancer.",
author = "Win, {Aung Ko} and Lindor, {Noralane Morey} and Ingrid Winship and Tucker, {Katherine M.} and Buchanan, {Daniel D.} and Young, {Joanne P.} and Christophe Rosty and Barbara Leggett and Giles, {Graham G.} and Jack Goldblatt and MacRae, {Finlay A.} and Susan Parry and Kalady, {Matthew F.} and Baron, {John A.} and Ahnen, {Dennis J.} and Marchand, {Loic Le} and Steven Gallinger and Haile, {Robert W.} and Newcomb, {Polly A.} and Hopper, {John L.} and Jenkins, {Mark A.}",
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T1 - Risks of colorectal and other cancers after endometrial cancer for women with lynch syndrome

AU - Win, Aung Ko

AU - Lindor, Noralane Morey

AU - Winship, Ingrid

AU - Tucker, Katherine M.

AU - Buchanan, Daniel D.

AU - Young, Joanne P.

AU - Rosty, Christophe

AU - Leggett, Barbara

AU - Giles, Graham G.

AU - Goldblatt, Jack

AU - MacRae, Finlay A.

AU - Parry, Susan

AU - Kalady, Matthew F.

AU - Baron, John A.

AU - Ahnen, Dennis J.

AU - Marchand, Loic Le

AU - Gallinger, Steven

AU - Haile, Robert W.

AU - Newcomb, Polly A.

AU - Hopper, John L.

AU - Jenkins, Mark A.

PY - 2013/2/20

Y1 - 2013/2/20

N2 - Background Lynch syndrome is an autosomal dominantly inherited disorder caused by germline mutations in DNA mismatch repair (MMR) genes. Previous studies have shown that MMR gene mutation carriers are at increased risk of colorectal, endometrial, and several other cancers following an initial diagnosis of colorectal cancer. We estimated cancer risks following an endometrial cancer diagnosis for women carrying MMR gene mutations. Methods We obtained data from the Colon Cancer Family Registry for a cohort of 127 women who had a diagnosis of endometrial cancer and who carried a mutation in one of four MMR genes (30 carried a mutation in MLH1, 72 in MSH2, 22 in MSH6, and 3 in PMS2). We used the Kaplan-Meier method to estimate 10- and 20-year cumulative risks for each cancer. We estimated the age-, country-, and calendar period-specific standardized incidence ratios (SIRs) for each cancer, compared with the general population. Results Following endometrial cancer, women carrying MMR gene mutations had the following 20-year risks of other cancer cancers: colorectal cancer (48%, 95% confidence interval [CI] = 35% to 62%); cancer of the kidney, renal pelvis, or ureter (11%, 95% CI = 3% to 20%); urinary bladder cancer (9%, 95% CI = 2% to 17%); and breast cancer (11%, 95% CI = 4% to 19%). Compared with the general population, these women were at statistically significantly elevated risks of colorectal cancer (SIR = 39.9, 95% CI = 27.2 to 58.3), cancer of the kidney, renal pelvis, or ureter (SIR = 28.3, 95% CI = 11.9 to 48.6), urinary bladder cancer (SIR = 24.3, 95% CI = 8.56 to 42.9), and breast cancer (SIR = 2.51, 95% CI = 1.17 to 4.14). Conclusions Women with Lynch syndrome who are diagnosed with endometrial cancer have increased risks of several cancers, including breast cancer.

AB - Background Lynch syndrome is an autosomal dominantly inherited disorder caused by germline mutations in DNA mismatch repair (MMR) genes. Previous studies have shown that MMR gene mutation carriers are at increased risk of colorectal, endometrial, and several other cancers following an initial diagnosis of colorectal cancer. We estimated cancer risks following an endometrial cancer diagnosis for women carrying MMR gene mutations. Methods We obtained data from the Colon Cancer Family Registry for a cohort of 127 women who had a diagnosis of endometrial cancer and who carried a mutation in one of four MMR genes (30 carried a mutation in MLH1, 72 in MSH2, 22 in MSH6, and 3 in PMS2). We used the Kaplan-Meier method to estimate 10- and 20-year cumulative risks for each cancer. We estimated the age-, country-, and calendar period-specific standardized incidence ratios (SIRs) for each cancer, compared with the general population. Results Following endometrial cancer, women carrying MMR gene mutations had the following 20-year risks of other cancer cancers: colorectal cancer (48%, 95% confidence interval [CI] = 35% to 62%); cancer of the kidney, renal pelvis, or ureter (11%, 95% CI = 3% to 20%); urinary bladder cancer (9%, 95% CI = 2% to 17%); and breast cancer (11%, 95% CI = 4% to 19%). Compared with the general population, these women were at statistically significantly elevated risks of colorectal cancer (SIR = 39.9, 95% CI = 27.2 to 58.3), cancer of the kidney, renal pelvis, or ureter (SIR = 28.3, 95% CI = 11.9 to 48.6), urinary bladder cancer (SIR = 24.3, 95% CI = 8.56 to 42.9), and breast cancer (SIR = 2.51, 95% CI = 1.17 to 4.14). Conclusions Women with Lynch syndrome who are diagnosed with endometrial cancer have increased risks of several cancers, including breast cancer.

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