Risk of colorectal cancer for carriers of mutations in MUTYH, with and without a family history of cancer

Aung Ko Win, James G. Dowty, Sean P. Cleary, Hyeja Kim, Daniel D. Buchanan, Joanne P. Young, Mark Clendenning, Christophe Rosty, Robert J. Macinnis, Graham G. Giles, Alex Boussioutas, Finlay A. Macrae, Susan Parry, Jack Goldblatt, John A. Baron, Terrilea Burnett, Loïc Le Marchand, Polly A. Newcomb, Robert W. Haile, John L. HopperMichelle Cotterchio, Steven Gallinger, Noralane M. Lindor, Katherine M. Tucker, Ingrid M. Winship, Mark A. Jenkins

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

We studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of 264 colorectal cancer (CRC) cases with a MUTYH mutation. We estimated CRC risks through 70 years of age of 7.2% for male carriers of monoallelic mutations (95% confidence interval [CI], 4.6%-11.3%) and 5.6% for female carriers of monoallelic mutations (95% CI, 3.6%-8.8%), irrespective of family history. For monoallelic MUTYH mutation carriers with a first-degree relative with CRC diagnosed by 50 years of age who does not have the MUTYH mutation, risks of CRC were 12.5% for men (95% CI, 8.6%-17.7%) and 10% for women (95% CI, 6.7%-14.4%). Risks of CRC for carriers of monoallelic mutations in MUTYH with a first-degree relative with CRC are sufficiently high to warrant more intensive screening than for the general population.

Original languageEnglish (US)
Pages (from-to)1208-1211.e5
JournalGastroenterology
Volume146
Issue number5
DOIs
StatePublished - May 2014

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Keywords

  • Base Excision Repair Gene
  • Colon Cancer
  • DNA Damage Response
  • Genetics
  • Keywords

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Win, A. K., Dowty, J. G., Cleary, S. P., Kim, H., Buchanan, D. D., Young, J. P., Clendenning, M., Rosty, C., Macinnis, R. J., Giles, G. G., Boussioutas, A., Macrae, F. A., Parry, S., Goldblatt, J., Baron, J. A., Burnett, T., Le Marchand, L., Newcomb, P. A., Haile, R. W., ... Jenkins, M. A. (2014). Risk of colorectal cancer for carriers of mutations in MUTYH, with and without a family history of cancer. Gastroenterology, 146(5), 1208-1211.e5. https://doi.org/10.1053/j.gastro.2014.01.022