TY - JOUR
T1 - Risk factors for pancreatic neuroendocrine tumors a clinic-based case-control study
AU - Halfdanarson, Thorvardur R.
AU - Bamlet, William R.
AU - McWilliams, Robert R.
AU - Hobday, Timothy J.
AU - Burch, Patrick A.
AU - Rabe, Kari G.
AU - Petersen, Gloria M.
N1 - Publisher Copyright:
Copyright © 2014 by Lippincott Williams & Wilkins.
PY - 2014/11/10
Y1 - 2014/11/10
N2 - Objectives: Pancreatic neuroendocrine tumors (PNETs) are uncommon, and little is known about their risk factors and association with other cancers. We evaluated whether the following risk factors known to be associated with pancreatic adenocarcinoma are also associated with PNETs: smoking, alcohol use, family history of PNET, and other cancers, and personal history of diabetes as potential risk factors.Methods: Patients with PNETs seen at Mayo Clinic Rochester between 2000 and 2011 were compared with controls seen for a general medical evaluation. Patients and controls completed the same questionnaires. After excluding insulinoma and high-grade PNETs, 355 cases were evaluated, and 309 were matched to 602 controls (2:1) on age, sex, and region of residence.Results: Personal smoking history was not associated with PNETs. Alcohol use was less common among cases (54% vs 67%, P < 0.001). Cases were more likely to report a family member with sarcoma (P = 0.02), PNET (P = 0.02), gallbladder cancer (P = 0.02), ovarian cancer (P = 0.04), and gastric cancer (P = 0.01). There was no association with other cancers in family members. Diabetes was more commonly reported by cases than controls (19% vs 11%, P < 0.001).Conclusions: With the exception of diabetes, risk factors that are associated with pancreatic adenocarcinoma are not risk factors for PNETs.
AB - Objectives: Pancreatic neuroendocrine tumors (PNETs) are uncommon, and little is known about their risk factors and association with other cancers. We evaluated whether the following risk factors known to be associated with pancreatic adenocarcinoma are also associated with PNETs: smoking, alcohol use, family history of PNET, and other cancers, and personal history of diabetes as potential risk factors.Methods: Patients with PNETs seen at Mayo Clinic Rochester between 2000 and 2011 were compared with controls seen for a general medical evaluation. Patients and controls completed the same questionnaires. After excluding insulinoma and high-grade PNETs, 355 cases were evaluated, and 309 were matched to 602 controls (2:1) on age, sex, and region of residence.Results: Personal smoking history was not associated with PNETs. Alcohol use was less common among cases (54% vs 67%, P < 0.001). Cases were more likely to report a family member with sarcoma (P = 0.02), PNET (P = 0.02), gallbladder cancer (P = 0.02), ovarian cancer (P = 0.04), and gastric cancer (P = 0.01). There was no association with other cancers in family members. Diabetes was more commonly reported by cases than controls (19% vs 11%, P < 0.001).Conclusions: With the exception of diabetes, risk factors that are associated with pancreatic adenocarcinoma are not risk factors for PNETs.
KW - Carcinoid tumors
KW - Islet cell tumors
KW - Neuroendocrine tumors
KW - Pancreatic neuroendocrine tumors
KW - Risk factors
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U2 - 10.1097/MPA.0000000000000234
DO - 10.1097/MPA.0000000000000234
M3 - Article
C2 - 25291526
AN - SCOPUS:84916594530
SN - 0885-3177
VL - 43
SP - 1219
EP - 1222
JO - Pancreas
JF - Pancreas
IS - 8
ER -