Risk factors for meningioma in postmenopausal women

Results from the Iowa Women's Health Study

Derek R. Johnson, Janet E Olson, Robert A. Vierkant, Julie E. Hammack, Alice H. Wang, Aaron R. Folsom, Beth A. Virnig, James R Cerhan

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Few risk factors for meningioma, aside from increasing age and female sex, have been identified. We investigated risk factors for meningioma in elderly women, a group with a high incidence. We evaluated associations of demographic, lifestyle, medical history, and anthropometric variables with risk of meningioma in the Iowa Women's Health Study (IWHS), a population-based prospective cohort study. Risk factors were collected via questionnaires mailed in 1986 and 1992. Incident meningiomas were identified via linkages to Medicare. Cox regression models were used to examine the association of risk factors with meningioma incidence. The mean age at baseline of the 27,791 women in the analysis cohort was 69.3 years (range, 65.0-84.6 years). During 291,021 person-years of follow-up, 125 incident meningiomas were identified. After adjusting for age, lower levels of physical activity (relative risk [RR] , 0.68 for high versus low; P for trend = .039), greater body mass index (BMI; RR, 2.14 for ≥35 versus 19.5- 24.9 kg/m 2; P for trend = .0019), greater height (RR, 2.04 for >66 versus ≤62 inches; P for trend = .013), and a history of uterine fibroids (RR, 1.72; 95% confidence interval, 1.19, 2.50) were positively associated with meningioma risk in multivariate analysis. BMI at age 18 and 30 years were not associated with risk. There were no associations with menstrual or reproductive factors or other medical history and lifestyle factors. Physical activity, BMI, height, and history of uterine fibroids were associated with meningioma risk in older women. The positive association with height suggests a role for early life influences on risk, whereas the associations with BMI and physical activity suggest a role for modifiable factors later in life.

Original languageEnglish (US)
Pages (from-to)1011-1019
Number of pages9
JournalNeuro-Oncology
Volume13
Issue number9
DOIs
StatePublished - Sep 2011

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Meningioma
Women's Health
Leiomyoma
Exercise
Life Style
Cohort Studies
Incidence
Medicare
Proportional Hazards Models
Body Mass Index
Multivariate Analysis
Demography
Prospective Studies
Confidence Intervals

Keywords

  • Cohort studies
  • Epidemiology
  • Primary brain tumor
  • Risk factors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Clinical Neurology

Cite this

Risk factors for meningioma in postmenopausal women : Results from the Iowa Women's Health Study. / Johnson, Derek R.; Olson, Janet E; Vierkant, Robert A.; Hammack, Julie E.; Wang, Alice H.; Folsom, Aaron R.; Virnig, Beth A.; Cerhan, James R.

In: Neuro-Oncology, Vol. 13, No. 9, 09.2011, p. 1011-1019.

Research output: Contribution to journalArticle

Johnson, DR, Olson, JE, Vierkant, RA, Hammack, JE, Wang, AH, Folsom, AR, Virnig, BA & Cerhan, JR 2011, 'Risk factors for meningioma in postmenopausal women: Results from the Iowa Women's Health Study', Neuro-Oncology, vol. 13, no. 9, pp. 1011-1019. https://doi.org/10.1093/neuonc/nor081
Johnson, Derek R. ; Olson, Janet E ; Vierkant, Robert A. ; Hammack, Julie E. ; Wang, Alice H. ; Folsom, Aaron R. ; Virnig, Beth A. ; Cerhan, James R. / Risk factors for meningioma in postmenopausal women : Results from the Iowa Women's Health Study. In: Neuro-Oncology. 2011 ; Vol. 13, No. 9. pp. 1011-1019.
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