Risk factors for malignant progression of intraductal papillary mucinous neoplasms

Maria Moris, Massimo Raimondo, Timothy A. Woodward, Verna Skinner, Paolo G. Arcidiacono, Maria C. Petrone, Claudio De Angelis, Selene Manfrè, Pietro Fusaroli, Michael B. Wallace

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Intraductal papillary mucinous neoplasms of the pancreas are increasingly diagnosed. Due to their malignant potential, greater understanding of their nature is required. Aims: Define risk factors for malignancy in intraductal papillary mucinous neoplasms. Methods: An international, multicentre study was performed in Europe and the United States. Clinical databases were reviewed for patients with intraductal papillary mucinous neoplasms diagnosis. Results: Of 1126 patients, 84 were diagnosed with invasive carcinoma/high-grade dysplasia and were compared to the rest of the cohort. Multivariate logistic analysis showed a statistically significant association between cancer/high-grade dysplasia and the variables smoking history (OR 1.9, 95% CI [1.1-3.1]), body mass index (OR 1.1, 95% CI [1-1.1]), symptoms (OR 3.4, 95% CI [1.9-6]), jaundice (OR 0.1, 95% CI [0-0.3]), and steatorrhea (OR 0.3, 95% CI [0.1-0.8]). Univariate analysis showed no association between malignancy and the cyst number/location (. p=. 0.3 and p=. 0.5, respectively) although a strong association was shown for cyst size (. p<. 0.001). The presence and size of nodules (. p<. 0.01) and main duct involvement (. p<. 0.001) were also strongly related with malignancy. Conclusion: The presence of jaundice and steatorrhea, smoking, high body mass index, and imaging features such as cyst size, main duct involvement, and the presence and size of mural nodules are associated with high-grade neoplasia in intraductal papillary mucinous neoplasms.

Original languageEnglish (US)
Pages (from-to)495-501
Number of pages7
JournalDigestive and Liver Disease
Volume47
Issue number6
DOIs
StatePublished - Jun 1 2015

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Neoplasms
Steatorrhea
Cysts
Jaundice
Body Mass Index
Smoking
Pancreatic Neoplasms
Multicenter Studies
Multivariate Analysis
History
Databases
Carcinoma

Keywords

  • Pancreatic adenocarcinoma
  • Pancreatic cystic neoplasm

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Moris, M., Raimondo, M., Woodward, T. A., Skinner, V., Arcidiacono, P. G., Petrone, M. C., ... Wallace, M. B. (2015). Risk factors for malignant progression of intraductal papillary mucinous neoplasms. Digestive and Liver Disease, 47(6), 495-501. https://doi.org/10.1016/j.dld.2015.03.007

Risk factors for malignant progression of intraductal papillary mucinous neoplasms. / Moris, Maria; Raimondo, Massimo; Woodward, Timothy A.; Skinner, Verna; Arcidiacono, Paolo G.; Petrone, Maria C.; De Angelis, Claudio; Manfrè, Selene; Fusaroli, Pietro; Wallace, Michael B.

In: Digestive and Liver Disease, Vol. 47, No. 6, 01.06.2015, p. 495-501.

Research output: Contribution to journalArticle

Moris, M, Raimondo, M, Woodward, TA, Skinner, V, Arcidiacono, PG, Petrone, MC, De Angelis, C, Manfrè, S, Fusaroli, P & Wallace, MB 2015, 'Risk factors for malignant progression of intraductal papillary mucinous neoplasms', Digestive and Liver Disease, vol. 47, no. 6, pp. 495-501. https://doi.org/10.1016/j.dld.2015.03.007
Moris, Maria ; Raimondo, Massimo ; Woodward, Timothy A. ; Skinner, Verna ; Arcidiacono, Paolo G. ; Petrone, Maria C. ; De Angelis, Claudio ; Manfrè, Selene ; Fusaroli, Pietro ; Wallace, Michael B. / Risk factors for malignant progression of intraductal papillary mucinous neoplasms. In: Digestive and Liver Disease. 2015 ; Vol. 47, No. 6. pp. 495-501.
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abstract = "Background: Intraductal papillary mucinous neoplasms of the pancreas are increasingly diagnosed. Due to their malignant potential, greater understanding of their nature is required. Aims: Define risk factors for malignancy in intraductal papillary mucinous neoplasms. Methods: An international, multicentre study was performed in Europe and the United States. Clinical databases were reviewed for patients with intraductal papillary mucinous neoplasms diagnosis. Results: Of 1126 patients, 84 were diagnosed with invasive carcinoma/high-grade dysplasia and were compared to the rest of the cohort. Multivariate logistic analysis showed a statistically significant association between cancer/high-grade dysplasia and the variables smoking history (OR 1.9, 95{\%} CI [1.1-3.1]), body mass index (OR 1.1, 95{\%} CI [1-1.1]), symptoms (OR 3.4, 95{\%} CI [1.9-6]), jaundice (OR 0.1, 95{\%} CI [0-0.3]), and steatorrhea (OR 0.3, 95{\%} CI [0.1-0.8]). Univariate analysis showed no association between malignancy and the cyst number/location (. p=. 0.3 and p=. 0.5, respectively) although a strong association was shown for cyst size (. p<. 0.001). The presence and size of nodules (. p<. 0.01) and main duct involvement (. p<. 0.001) were also strongly related with malignancy. Conclusion: The presence of jaundice and steatorrhea, smoking, high body mass index, and imaging features such as cyst size, main duct involvement, and the presence and size of mural nodules are associated with high-grade neoplasia in intraductal papillary mucinous neoplasms.",
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T1 - Risk factors for malignant progression of intraductal papillary mucinous neoplasms

AU - Moris, Maria

AU - Raimondo, Massimo

AU - Woodward, Timothy A.

AU - Skinner, Verna

AU - Arcidiacono, Paolo G.

AU - Petrone, Maria C.

AU - De Angelis, Claudio

AU - Manfrè, Selene

AU - Fusaroli, Pietro

AU - Wallace, Michael B.

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N2 - Background: Intraductal papillary mucinous neoplasms of the pancreas are increasingly diagnosed. Due to their malignant potential, greater understanding of their nature is required. Aims: Define risk factors for malignancy in intraductal papillary mucinous neoplasms. Methods: An international, multicentre study was performed in Europe and the United States. Clinical databases were reviewed for patients with intraductal papillary mucinous neoplasms diagnosis. Results: Of 1126 patients, 84 were diagnosed with invasive carcinoma/high-grade dysplasia and were compared to the rest of the cohort. Multivariate logistic analysis showed a statistically significant association between cancer/high-grade dysplasia and the variables smoking history (OR 1.9, 95% CI [1.1-3.1]), body mass index (OR 1.1, 95% CI [1-1.1]), symptoms (OR 3.4, 95% CI [1.9-6]), jaundice (OR 0.1, 95% CI [0-0.3]), and steatorrhea (OR 0.3, 95% CI [0.1-0.8]). Univariate analysis showed no association between malignancy and the cyst number/location (. p=. 0.3 and p=. 0.5, respectively) although a strong association was shown for cyst size (. p<. 0.001). The presence and size of nodules (. p<. 0.01) and main duct involvement (. p<. 0.001) were also strongly related with malignancy. Conclusion: The presence of jaundice and steatorrhea, smoking, high body mass index, and imaging features such as cyst size, main duct involvement, and the presence and size of mural nodules are associated with high-grade neoplasia in intraductal papillary mucinous neoplasms.

AB - Background: Intraductal papillary mucinous neoplasms of the pancreas are increasingly diagnosed. Due to their malignant potential, greater understanding of their nature is required. Aims: Define risk factors for malignancy in intraductal papillary mucinous neoplasms. Methods: An international, multicentre study was performed in Europe and the United States. Clinical databases were reviewed for patients with intraductal papillary mucinous neoplasms diagnosis. Results: Of 1126 patients, 84 were diagnosed with invasive carcinoma/high-grade dysplasia and were compared to the rest of the cohort. Multivariate logistic analysis showed a statistically significant association between cancer/high-grade dysplasia and the variables smoking history (OR 1.9, 95% CI [1.1-3.1]), body mass index (OR 1.1, 95% CI [1-1.1]), symptoms (OR 3.4, 95% CI [1.9-6]), jaundice (OR 0.1, 95% CI [0-0.3]), and steatorrhea (OR 0.3, 95% CI [0.1-0.8]). Univariate analysis showed no association between malignancy and the cyst number/location (. p=. 0.3 and p=. 0.5, respectively) although a strong association was shown for cyst size (. p<. 0.001). The presence and size of nodules (. p<. 0.01) and main duct involvement (. p<. 0.001) were also strongly related with malignancy. Conclusion: The presence of jaundice and steatorrhea, smoking, high body mass index, and imaging features such as cyst size, main duct involvement, and the presence and size of mural nodules are associated with high-grade neoplasia in intraductal papillary mucinous neoplasms.

KW - Pancreatic adenocarcinoma

KW - Pancreatic cystic neoplasm

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