Risk factors for growth of intracranial aneurysms: A systematic review and meta-analysis

Waleed Brinjikji, Y. Q. Zhu, G. Lanzino, H. J. Cloft, Mohammad H Murad, Zhen Wang, David F Kallmes

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

BACKGROUND AND PURPOSE: Understanding risk factors for intracranial aneurysm growth is important for patient management. We performed a meta-analysis examining risk factors for intracranial aneurysm growth in longitudinal studies and examined the association between aneurysm growth and rupture. MATERIALS AND METHODS: We searched the literature for longitudinal studies of patients with unruptured aneurysms. We examined the associations of demographics, multiple aneurysms, prior subarachnoid hemorrhage, family history of aneurysm or subarachnoid hemorrhage, smoking, and hypertension; and aneurysm shape, size, and location with aneurysm growth. We studied the association between aneurysm growth and rupture. A meta-analysis was performed by using a random-effects model by using summary statistics from included studies. RESULTS: Twenty-one studies including 3954 patients with 4990 aneurysms with 13,294 aneurysm-years of follow-up were included. The overall proportion of growing aneurysms was 3.0% per aneurysm-year (95% CI, 2.0%-4.0%). Patient risk factors for growth included age older than 50 years (3.8% per year versus 0.9% per year, P

Original languageEnglish (US)
Pages (from-to)615-620
Number of pages6
JournalAmerican Journal of Neuroradiology
Volume37
Issue number4
DOIs
StatePublished - Apr 1 2016

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging

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