Risk factors and hormone levels in patients with serous and endometrioid uterine carcinomas

Mark E. Sherman, Susan Sturgeon, Louise A. Brinton, Nancy Potischman, Robert J. Kurman, Michael L. Berman, Rodrigue Mortel, Leo B. Twiggs, Rolland J. Barrett, George D. Wilbanks

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

We performed a multi-institutional, incident case-control study of 328 endometrioid and 26 serous carcinomas to assess whether risk factors and circulating hormone levels in women with serous carcinoma differ from the expected profile for endometrial carcinoma. We also evaluated exposures potentially related to endometrial cancer risk, anthropometric measurements, and circulating levels of sex hormones and related carrier proteins. Histopathologic specimens were reviewed without knowledge of the other data. As expected, a statistically significant association was observed for high body mass index (BMI) (relative risk, 3.5) and use of menopausal estrogens (relative risk, 2.4) in the endometrioid carcinoma cases, whereas serous carcinomas were not strongly associated with these factors. Smoking and oral contraceptive use decreased risk for both tumor types. For five of six sex hormones tested, age-adjusted mean serum levels in patients with serous carcinoma were significantly lower than those in women with endometrioid carcinoma. After adjustment for BMI, these differences were narrowed, but levels of albumin-bound estradiol and estrone remained significantly lower in the serous cases. Age and BMI-adjusted levels of sex hormone-binding globulin were significantly higher in patients with serous carcinoma than in women with endometrioid carcinomas. In conclusion, risk factors and sex hormone levels in patients with uterine serous carcinoma seem to differ from those in women with endometrioid carcinoma, suggesting that there may be at least two different pathways of endometrial carcinogenesis.

Original languageEnglish (US)
Pages (from-to)963-968
Number of pages6
JournalModern Pathology
Volume10
Issue number10
StatePublished - Oct 1997

Fingerprint

Endometrioid Carcinoma
Hormones
Carcinoma
Gonadal Steroid Hormones
Body Mass Index
Endometrial Neoplasms
Sex Hormone-Binding Globulin
Estrone
Oral Contraceptives
Case-Control Studies
Albumins
Estradiol
Carrier Proteins
Estrogens
Carcinogenesis
Smoking
Serum
Neoplasms

Keywords

  • Endometrial carcinoma
  • Endometrioid
  • Hormones
  • Pathogenesis
  • Risk
  • Serous

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Sherman, M. E., Sturgeon, S., Brinton, L. A., Potischman, N., Kurman, R. J., Berman, M. L., ... Wilbanks, G. D. (1997). Risk factors and hormone levels in patients with serous and endometrioid uterine carcinomas. Modern Pathology, 10(10), 963-968.

Risk factors and hormone levels in patients with serous and endometrioid uterine carcinomas. / Sherman, Mark E.; Sturgeon, Susan; Brinton, Louise A.; Potischman, Nancy; Kurman, Robert J.; Berman, Michael L.; Mortel, Rodrigue; Twiggs, Leo B.; Barrett, Rolland J.; Wilbanks, George D.

In: Modern Pathology, Vol. 10, No. 10, 10.1997, p. 963-968.

Research output: Contribution to journalArticle

Sherman, ME, Sturgeon, S, Brinton, LA, Potischman, N, Kurman, RJ, Berman, ML, Mortel, R, Twiggs, LB, Barrett, RJ & Wilbanks, GD 1997, 'Risk factors and hormone levels in patients with serous and endometrioid uterine carcinomas', Modern Pathology, vol. 10, no. 10, pp. 963-968.
Sherman ME, Sturgeon S, Brinton LA, Potischman N, Kurman RJ, Berman ML et al. Risk factors and hormone levels in patients with serous and endometrioid uterine carcinomas. Modern Pathology. 1997 Oct;10(10):963-968.
Sherman, Mark E. ; Sturgeon, Susan ; Brinton, Louise A. ; Potischman, Nancy ; Kurman, Robert J. ; Berman, Michael L. ; Mortel, Rodrigue ; Twiggs, Leo B. ; Barrett, Rolland J. ; Wilbanks, George D. / Risk factors and hormone levels in patients with serous and endometrioid uterine carcinomas. In: Modern Pathology. 1997 ; Vol. 10, No. 10. pp. 963-968.
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