Right ventricular assessment in patients presenting for lung transplantation

W. T. Vigneswaran, J. C. McDougall, L. J. Olson, J. F. Breen, C. G A McGregor, J. A. Rumberger

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Chronic pulmonary disease is associated with varying degrees of cardiac dysfunction. Because of the potentially predominant effect of severe lung disease on right ventricular (RV) size and function, a reliable method to assess RV mechanics before and after lung transplantation may provide information of long-term significance and/or prognosis. Conventional invasive and noninvasive imaging methods have a number of limitations in evaluating RV function. Ultrafast computed tomographic (ultrafast CT) scanning has been shown to provide quantitative assessment of RV and left ventricular (LV) function in individuals with and without cardiac disease. Twenty-two patients presenting during evaluation for possible lung transplantation with end- stage pulmonary disease formed the basis of this study. There were 14 patients with chronic obstructive pulmonary disease and 8 with pulmonary fibrosis. Conventional transthoracic echocardiography and ultrafast CT were used for the assessment of RV and LV function. All patients had invasive assessment of right-sided hemodynamics and pulmonary function studies performed within 7-10 days of cardiac imaging. A qualitative assessment of RV size or function was possible in all but two patients by echocardiogram, but in 45%, the echocardiographic examination was described as suboptimal. In contrast, a quantitative assessment of ventricular volumes and systolic function was obtained in all patients by ultrafast CT. Pulmonary function parameters or hemodynamic measurements obtained during cardiac catheterization did not correlate with any assessment of RV function. We concluded that (1) ultrafast CT provides measurement of the RV and LV cavity dimension and systolic function; (2) invasive right-sided hemodynamics or pulmonary function studies do not predict RV function; and (3) echocardiography does not uniformly provide assessment of RV function in patients with chronic pulmonary disease.

Original languageEnglish (US)
Pages (from-to)1051-1055
Number of pages5
JournalTransplantation
Volume55
Issue number5
StatePublished - 1993

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Lung Transplantation
Right Ventricular Function
Lung Diseases
Hemodynamics
Left Ventricular Function
Lung
Echocardiography
Chronic Disease
Pulmonary Fibrosis
Cardiac Catheterization
Mechanics
Chronic Obstructive Pulmonary Disease
Heart Diseases

ASJC Scopus subject areas

  • Immunology
  • Transplantation

Cite this

Vigneswaran, W. T., McDougall, J. C., Olson, L. J., Breen, J. F., McGregor, C. G. A., & Rumberger, J. A. (1993). Right ventricular assessment in patients presenting for lung transplantation. Transplantation, 55(5), 1051-1055.

Right ventricular assessment in patients presenting for lung transplantation. / Vigneswaran, W. T.; McDougall, J. C.; Olson, L. J.; Breen, J. F.; McGregor, C. G A; Rumberger, J. A.

In: Transplantation, Vol. 55, No. 5, 1993, p. 1051-1055.

Research output: Contribution to journalArticle

Vigneswaran, WT, McDougall, JC, Olson, LJ, Breen, JF, McGregor, CGA & Rumberger, JA 1993, 'Right ventricular assessment in patients presenting for lung transplantation', Transplantation, vol. 55, no. 5, pp. 1051-1055.
Vigneswaran WT, McDougall JC, Olson LJ, Breen JF, McGregor CGA, Rumberger JA. Right ventricular assessment in patients presenting for lung transplantation. Transplantation. 1993;55(5):1051-1055.
Vigneswaran, W. T. ; McDougall, J. C. ; Olson, L. J. ; Breen, J. F. ; McGregor, C. G A ; Rumberger, J. A. / Right ventricular assessment in patients presenting for lung transplantation. In: Transplantation. 1993 ; Vol. 55, No. 5. pp. 1051-1055.
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