TY - JOUR
T1 - Rheumatoid lung disease
T2 - Prognostic analysis of 54 biopsy-proven cases
AU - Nakamura, Yutaro
AU - Suda, Takafumi
AU - Kaida, Yusuke
AU - Kono, Masato
AU - Hozumi, Hironao
AU - Hashimoto, Dai
AU - Enomoto, Noriyuki
AU - Fujisawa, Tomoyuki
AU - Inui, Naoki
AU - Imokawa, Shiro
AU - Yasuda, Kazumasa
AU - Shirai, Toshihiro
AU - Suganuma, Hideki
AU - Morita, Satoru
AU - Hayakawa, Hiroshi
AU - Takehara, Yasuo
AU - Colby, Thomas V.
AU - Chida, Kingo
N1 - Funding Information:
This study was partly supported by a grant to the Diffuse Lung Diseases Research Group from the Ministry of Health, Labor and Welfare, Japan . We thank Dr. Noriyoshi Ogawa for helpful comments and discussions.
PY - 2012/8
Y1 - 2012/8
N2 - Objective: To investigate the prognostic significance of histopathological characteristics in patients with biopsy-proven rheumatoid lung disease (RLD). Materials and methods: Retrospective analysis was conducted on samples from 54 RLD patients who underwent surgical lung biopsies (SLBs) at Hamamatsu University Hospital and affiliated hospitals between 1980 and 2009. The overall survival rate, the spectrum of histopathological diagnosis and their associated prognostic significance were investigated. Results: The study group consisted of 30 men and 24 women with a median age of 60.3 years. Histopathological analysis revealed the following: usual interstitial pneumonia (UIP), 15 cases; nonspecific interstitial pneumonia/fibrosis, 16 cases; organizing pneumonia, 4 cases; unclassifiable, 2 cases; desquamative interstitial pneumonia, 1 case; and bronchiolar disease, 16 cases. In survival outcome, 10 yr survival rate was 76.6%. Patients with UIP had significantly worse prognosis than those with non-UIP (RLD cases except those with UIP) (p = 0.0452). Conclusion: RLD includes several histopathological groups. Patients with UIP have worse survival than those with other types of RLD. Histopathological diagnosis may have a major impact on prognostication in patients with RLD.
AB - Objective: To investigate the prognostic significance of histopathological characteristics in patients with biopsy-proven rheumatoid lung disease (RLD). Materials and methods: Retrospective analysis was conducted on samples from 54 RLD patients who underwent surgical lung biopsies (SLBs) at Hamamatsu University Hospital and affiliated hospitals between 1980 and 2009. The overall survival rate, the spectrum of histopathological diagnosis and their associated prognostic significance were investigated. Results: The study group consisted of 30 men and 24 women with a median age of 60.3 years. Histopathological analysis revealed the following: usual interstitial pneumonia (UIP), 15 cases; nonspecific interstitial pneumonia/fibrosis, 16 cases; organizing pneumonia, 4 cases; unclassifiable, 2 cases; desquamative interstitial pneumonia, 1 case; and bronchiolar disease, 16 cases. In survival outcome, 10 yr survival rate was 76.6%. Patients with UIP had significantly worse prognosis than those with non-UIP (RLD cases except those with UIP) (p = 0.0452). Conclusion: RLD includes several histopathological groups. Patients with UIP have worse survival than those with other types of RLD. Histopathological diagnosis may have a major impact on prognostication in patients with RLD.
KW - Connective tissue disease
KW - Histopathological diagnosis
KW - Interstitial lung disease
KW - Prognosis
KW - Rheumatoid arthritis
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U2 - 10.1016/j.rmed.2012.04.004
DO - 10.1016/j.rmed.2012.04.004
M3 - Article
C2 - 22560113
AN - SCOPUS:84862515696
SN - 0954-6111
VL - 106
SP - 1164
EP - 1169
JO - Respiratory Medicine
JF - Respiratory Medicine
IS - 8
ER -