Review - Cronkhite-Canada syndrome: An acquired condition of gastrointestinal polyposis and dermatologic abnormalities

The report by Seshadri and colleagues describes a patient diagnosed with the rare gastrointestinal polyposis syndrome of CCS based on a combination of clinical, endoscopic, and pathologic findings.1 The diagnosis of CCS should be considered in patients with gastrointestinal hamartomatous polyps, diarrhea, and the dermatologic triad of alopecia, hyperpigmentation, and onychodystrophy. Malignant transformation of CCS polyps may occur, and the risk of colorectal cancer may warrant aggressive screening in CCS patients. Immunosuppression with corticosteroids or long-term azathioprine therapy may eradicate or lessen manifestations of CCS.