Reversible akinetic mutism possibly induced by baclofen

Devon I. Rubin, Elson L. So

Research output: Contribution to journalArticle

12 Scopus citations


A 76-year-old man developed akinetic mutism after 3 days of receiving low-dosage baclofen. Electroencephalography showed a diffusely slow background with intermittent generalized sharp wave discharges. The condition resolved after discontinuing baclofen. To our knowledge, this is the first reported case of baclofen-induced akinetic mutism in a patient with normal renal function. The pathophysiology of this condition is unknown, but it may result from selective binding of the drug to the γ-aminobutyric acid-B receptors located in the frontal lobes or thalamic nuclei, interrupting the thalamocortical limbic pathways.

Original languageEnglish (US)
Pages (from-to)468-470
Number of pages3
Issue number4 I
StatePublished - 1999


ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Rubin, D. I., & So, E. L. (1999). Reversible akinetic mutism possibly induced by baclofen. Pharmacotherapy, 19(4 I), 468-470.