Abstract
A 76-year-old man developed akinetic mutism after 3 days of receiving low-dosage baclofen. Electroencephalography showed a diffusely slow background with intermittent generalized sharp wave discharges. The condition resolved after discontinuing baclofen. To our knowledge, this is the first reported case of baclofen-induced akinetic mutism in a patient with normal renal function. The pathophysiology of this condition is unknown, but it may result from selective binding of the drug to the γ-aminobutyric acid-B receptors located in the frontal lobes or thalamic nuclei, interrupting the thalamocortical limbic pathways.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 468-470 |
| Number of pages | 3 |
| Journal | Pharmacotherapy |
| Volume | 19 |
| Issue number | 4 I |
| DOIs | |
| State | Published - 1999 |
ASJC Scopus subject areas
- Pharmacology (medical)