Retinoic acid isomers facilitate apolipoprotein e production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway

Jing Zhao; Yuan Fu; Chia Chen Liu; Mitsuru Shinohara; Henrietta M. Nielsen; Qiang Dong; Takahisa Kanekiyo; Guojun Bu

doi:10.1074/jbc.M113.526095

Retinoic acid isomers facilitate apolipoprotein e production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway

Jing Zhao, Yuan Fu, Chia Chen Liu, Mitsuru Shinohara, Henrietta M. Nielsen, Qiang Dong, Takahisa Kanekiyo, Guojun Bu

Neuroscience

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Background: Apolipoprotein E (apoE) isoforms influence the risk for Alzheimer disease (AD). Results: All-trans-retinoic acid (RA), 9-cis-RA, and 13-cis-RA were identified as compounds that increase apoE expression and lipidation in astrocytes. Conclusion: RA isomers are effective modulators of apoE production through the retinoid X receptor (RXR) and RA receptor (RAR). Significance: RXR/RAR agonists can be explored for AD therapy.

Original language	English (US)
Pages (from-to)	11282-11292
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	289
Issue number	16
DOIs	https://doi.org/10.1074/jbc.M113.526095
State	Published - Apr 18 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Retinoic acid isomers facilitate apolipoprotein e production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway",

abstract = "Background: Apolipoprotein E (apoE) isoforms influence the risk for Alzheimer disease (AD). Results: All-trans-retinoic acid (RA), 9-cis-RA, and 13-cis-RA were identified as compounds that increase apoE expression and lipidation in astrocytes. Conclusion: RA isomers are effective modulators of apoE production through the retinoid X receptor (RXR) and RA receptor (RAR). Significance: RXR/RAR agonists can be explored for AD therapy.",

author = "Jing Zhao and Yuan Fu and Liu, {Chia Chen} and Mitsuru Shinohara and Nielsen, {Henrietta M.} and Qiang Dong and Takahisa Kanekiyo and Guojun Bu",

year = "2014",

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doi = "10.1074/jbc.M113.526095",

language = "English (US)",

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pages = "11282--11292",

journal = "Journal of Biological Chemistry",

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T1 - Retinoic acid isomers facilitate apolipoprotein e production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway

AU - Zhao, Jing

AU - Fu, Yuan

AU - Liu, Chia Chen

AU - Shinohara, Mitsuru

AU - Nielsen, Henrietta M.

AU - Dong, Qiang

AU - Kanekiyo, Takahisa

AU - Bu, Guojun

PY - 2014/4/18

Y1 - 2014/4/18

N2 - Background: Apolipoprotein E (apoE) isoforms influence the risk for Alzheimer disease (AD). Results: All-trans-retinoic acid (RA), 9-cis-RA, and 13-cis-RA were identified as compounds that increase apoE expression and lipidation in astrocytes. Conclusion: RA isomers are effective modulators of apoE production through the retinoid X receptor (RXR) and RA receptor (RAR). Significance: RXR/RAR agonists can be explored for AD therapy.

AB - Background: Apolipoprotein E (apoE) isoforms influence the risk for Alzheimer disease (AD). Results: All-trans-retinoic acid (RA), 9-cis-RA, and 13-cis-RA were identified as compounds that increase apoE expression and lipidation in astrocytes. Conclusion: RA isomers are effective modulators of apoE production through the retinoid X receptor (RXR) and RA receptor (RAR). Significance: RXR/RAR agonists can be explored for AD therapy.

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Retinoic acid isomers facilitate apolipoprotein e production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway

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