Retinoic acid isomers facilitate apolipoprotein e production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway

Jing Zhao, Yuan Fu, Chia Chen Liu, Mitsuru Shinohara, Henrietta M. Nielsen, Qiang Dong, Takahisa Kanekiyo, Guojun Bu

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Background: Apolipoprotein E (apoE) isoforms influence the risk for Alzheimer disease (AD). Results: All-trans-retinoic acid (RA), 9-cis-RA, and 13-cis-RA were identified as compounds that increase apoE expression and lipidation in astrocytes. Conclusion: RA isomers are effective modulators of apoE production through the retinoid X receptor (RXR) and RA receptor (RAR). Significance: RXR/RAR agonists can be explored for AD therapy.

Original languageEnglish (US)
Pages (from-to)11282-11292
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number16
DOIs
StatePublished - Apr 18 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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