Retinoic acid isomers facilitate apolipoprotein e production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway

Jing Zhao, Yuan Fu, Chia-Chen Liu, Mitsuru Shinohara, Henrietta M. Nielsen, Qiang Dong, Takahisa Kanekiyo, Guojun D Bu

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Apolipoprotein E (apoE) isoforms influence the risk for Alzheimer disease (AD). Results: All-trans-retinoic acid (RA), 9-cis-RA, and 13-cis-RA were identified as compounds that increase apoE expression and lipidation in astrocytes. Conclusion: RA isomers are effective modulators of apoE production through the retinoid X receptor (RXR) and RA receptor (RAR). Significance: RXR/RAR agonists can be explored for AD therapy.

Original languageEnglish (US)
Pages (from-to)11282-11292
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number16
DOIs
StatePublished - Apr 18 2014

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Retinoid X Receptors
Retinoic Acid Receptors
Apolipoproteins
Apolipoproteins E
Tretinoin
Astrocytes
Isomers
Alzheimer Disease
Isotretinoin
Modulators
Protein Isoforms
Acids
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Retinoic acid isomers facilitate apolipoprotein e production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway. / Zhao, Jing; Fu, Yuan; Liu, Chia-Chen; Shinohara, Mitsuru; Nielsen, Henrietta M.; Dong, Qiang; Kanekiyo, Takahisa; Bu, Guojun D.

In: Journal of Biological Chemistry, Vol. 289, No. 16, 18.04.2014, p. 11282-11292.

Research output: Contribution to journalArticle

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AU - Fu, Yuan

AU - Liu, Chia-Chen

AU - Shinohara, Mitsuru

AU - Nielsen, Henrietta M.

AU - Dong, Qiang

AU - Kanekiyo, Takahisa

AU - Bu, Guojun D

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AB - Background: Apolipoprotein E (apoE) isoforms influence the risk for Alzheimer disease (AD). Results: All-trans-retinoic acid (RA), 9-cis-RA, and 13-cis-RA were identified as compounds that increase apoE expression and lipidation in astrocytes. Conclusion: RA isomers are effective modulators of apoE production through the retinoid X receptor (RXR) and RA receptor (RAR). Significance: RXR/RAR agonists can be explored for AD therapy.

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