Retargeting adenoviruses for therapeutic applications and vaccines

Michael A. Barry, Jeffrey D. Rubin, Shao Chia Lu

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Adenoviruses (Ads) are robust vectors for therapeutic applications and vaccines, but their use can be limited by differences in their in vitro and in vivo pharmacologies. This review emphasizes that there is not just one Ad, but a whole virome of diverse viruses that can be used as therapeutics. It discusses that true vector targeting involves not only retargeting viruses, but importantly also detargeting the viruses from off-target cells.

Original languageEnglish (US)
Pages (from-to)1918-1946
Number of pages29
JournalFEBS Letters
Volume594
Issue number12
DOIs
StatePublished - Jun 1 2020

Keywords

  • Ad serotypes
  • detargeting
  • gain of function
  • liver
  • retargeting
  • sequestration
  • serotypes

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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