Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype

Massimo Santoro; Francesca Carlomagno; Ian D. Hay; Marie A. Herrmann; Michele Grieco; Rosamarina Melillo; Marco A. Pierotti; Italia Bongarzone; Giuseppe Della Porta; Nicole Berger; Jean Louis Peix; Christian Paulin; Nicole Fabien; Giancarlo Vecchio; Robert B. Jenkins; Alfredo Fusco

Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype

Massimo Santoro, Francesca Carlomagno, Ian D. Hay, Marie A. Herrmann, Michele Grieco, Rosamarina Melillo, Marco A. Pierotti, Italia Bongarzone, Giuseppe Della Porta, Nicole Berger, Jean Louis Peix, Christian Paulin, Nicole Fabien, Giancarlo Vecchio, Robert B. Jenkins, Alfredo Fusco

Research output: Contribution to journal › Article › peer-review

327 Scopus citations

Abstract

We have recently reported the activation of a new oncogene in human papillary thyroid carcinomas. This oncogene, papillary thyroid carcinoma (PTC), is a novel rearranged version of the ret tyrosine-kinase protooncogene. Thyroid neoplasms include a broad spectrum of malignant tumors, ranging from well-differentiated tumors to undifferentiated anaplastic carcinomas. To determine the frequency of ret oneogene activation, we analyzed 286 cases of human thyroid tumors of diverse histologic types. We found the presence of an activated form of the ret oncogene in 33 (19%) of 177 papillary carcinomas. By contrast, none of the other 109 thyroid tumors, which included 37 follicular, 15 anaplastic, and 18 medullary carcinomas, and 34 benign lesions, showed ret activation.

Original language	English (US)
Pages (from-to)	1517-1522
Number of pages	6
Journal	Journal of Clinical Investigation
Volume	89
Issue number	5
State	Published - 1992

Keywords

Carcinoma
Gene rearrangement
PTC
Ret pro- Tooncogene
Tyrosine kinase

ASJC Scopus subject areas

General Medicine

Cite this

Santoro, M., Carlomagno, F., Hay, I. D., Herrmann, M. A., Grieco, M., Melillo, R., Pierotti, M. A., Bongarzone, I., Porta, G. D., Berger, N., Peix, J. L., Paulin, C., Fabien, N., Vecchio, G., Jenkins, R. B., & Fusco, A. (1992). Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype. Journal of Clinical Investigation, 89(5), 1517-1522.

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title = "Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype",

abstract = "We have recently reported the activation of a new oncogene in human papillary thyroid carcinomas. This oncogene, papillary thyroid carcinoma (PTC), is a novel rearranged version of the ret tyrosine-kinase protooncogene. Thyroid neoplasms include a broad spectrum of malignant tumors, ranging from well-differentiated tumors to undifferentiated anaplastic carcinomas. To determine the frequency of ret oneogene activation, we analyzed 286 cases of human thyroid tumors of diverse histologic types. We found the presence of an activated form of the ret oncogene in 33 (19%) of 177 papillary carcinomas. By contrast, none of the other 109 thyroid tumors, which included 37 follicular, 15 anaplastic, and 18 medullary carcinomas, and 34 benign lesions, showed ret activation.",

keywords = "Carcinoma, Gene rearrangement, PTC, Ret pro- Tooncogene, Tyrosine kinase",

author = "Massimo Santoro and Francesca Carlomagno and Hay, {Ian D.} and Herrmann, {Marie A.} and Michele Grieco and Rosamarina Melillo and Pierotti, {Marco A.} and Italia Bongarzone and Porta, {Giuseppe Della} and Nicole Berger and Peix, {Jean Louis} and Christian Paulin and Nicole Fabien and Giancarlo Vecchio and Jenkins, {Robert B.} and Alfredo Fusco",

year = "1992",

language = "English (US)",

volume = "89",

pages = "1517--1522",

journal = "Journal of Clinical Investigation",

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TY - JOUR

T1 - Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype

AU - Santoro, Massimo

AU - Carlomagno, Francesca

AU - Hay, Ian D.

AU - Herrmann, Marie A.

AU - Grieco, Michele

AU - Melillo, Rosamarina

AU - Pierotti, Marco A.

AU - Bongarzone, Italia

AU - Porta, Giuseppe Della

AU - Berger, Nicole

AU - Peix, Jean Louis

AU - Paulin, Christian

AU - Fabien, Nicole

AU - Vecchio, Giancarlo

AU - Jenkins, Robert B.

AU - Fusco, Alfredo

PY - 1992

Y1 - 1992

N2 - We have recently reported the activation of a new oncogene in human papillary thyroid carcinomas. This oncogene, papillary thyroid carcinoma (PTC), is a novel rearranged version of the ret tyrosine-kinase protooncogene. Thyroid neoplasms include a broad spectrum of malignant tumors, ranging from well-differentiated tumors to undifferentiated anaplastic carcinomas. To determine the frequency of ret oneogene activation, we analyzed 286 cases of human thyroid tumors of diverse histologic types. We found the presence of an activated form of the ret oncogene in 33 (19%) of 177 papillary carcinomas. By contrast, none of the other 109 thyroid tumors, which included 37 follicular, 15 anaplastic, and 18 medullary carcinomas, and 34 benign lesions, showed ret activation.

AB - We have recently reported the activation of a new oncogene in human papillary thyroid carcinomas. This oncogene, papillary thyroid carcinoma (PTC), is a novel rearranged version of the ret tyrosine-kinase protooncogene. Thyroid neoplasms include a broad spectrum of malignant tumors, ranging from well-differentiated tumors to undifferentiated anaplastic carcinomas. To determine the frequency of ret oneogene activation, we analyzed 286 cases of human thyroid tumors of diverse histologic types. We found the presence of an activated form of the ret oncogene in 33 (19%) of 177 papillary carcinomas. By contrast, none of the other 109 thyroid tumors, which included 37 follicular, 15 anaplastic, and 18 medullary carcinomas, and 34 benign lesions, showed ret activation.

KW - Carcinoma

KW - Gene rearrangement

KW - PTC

KW - Ret pro- Tooncogene

KW - Tyrosine kinase

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M3 - Article

C2 - 1569189

AN - SCOPUS:0026763062

SN - 0021-9738

VL - 89

SP - 1517

EP - 1522

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

IS - 5

ER -

Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype

Abstract

Keywords

ASJC Scopus subject areas

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