Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype

Massimo Santoro, Francesca Carlomagno, Ian D Hay, Marie A. Herrmann, Michele Grieco, Rosamarina Melillo, Marco A. Pierotti, Italia Bongarzone, Giuseppe Della Porta, Nicole Berger, Jean Louis Peix, Christian Paulin, Nicole Fabien, Giancarlo Vecchio, Robert Brian Jenkins, Alfredo Fusco

Research output: Contribution to journalArticle

324 Citations (Scopus)

Abstract

We have recently reported the activation of a new oncogene in human papillary thyroid carcinomas. This oncogene, papillary thyroid carcinoma (PTC), is a novel rearranged version of the ret tyrosine-kinase protooncogene. Thyroid neoplasms include a broad spectrum of malignant tumors, ranging from well-differentiated tumors to undifferentiated anaplastic carcinomas. To determine the frequency of ret oneogene activation, we analyzed 286 cases of human thyroid tumors of diverse histologic types. We found the presence of an activated form of the ret oncogene in 33 (19%) of 177 papillary carcinomas. By contrast, none of the other 109 thyroid tumors, which included 37 follicular, 15 anaplastic, and 18 medullary carcinomas, and 34 benign lesions, showed ret activation.

Original languageEnglish (US)
Pages (from-to)1517-1522
Number of pages6
JournalJournal of Clinical Investigation
Volume89
Issue number5
StatePublished - 1992

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Oncogenes
Thyroid Neoplasms
Neoplasms
Thyroid Gland
Carcinoma
Medullary Carcinoma
Papillary Carcinoma
Protein-Tyrosine Kinases
Papillary Thyroid cancer

Keywords

  • Carcinoma
  • Gene rearrangement
  • PTC
  • Ret pro- Tooncogene
  • Tyrosine kinase

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Santoro, M., Carlomagno, F., Hay, I. D., Herrmann, M. A., Grieco, M., Melillo, R., ... Fusco, A. (1992). Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype. Journal of Clinical Investigation, 89(5), 1517-1522.

Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype. / Santoro, Massimo; Carlomagno, Francesca; Hay, Ian D; Herrmann, Marie A.; Grieco, Michele; Melillo, Rosamarina; Pierotti, Marco A.; Bongarzone, Italia; Porta, Giuseppe Della; Berger, Nicole; Peix, Jean Louis; Paulin, Christian; Fabien, Nicole; Vecchio, Giancarlo; Jenkins, Robert Brian; Fusco, Alfredo.

In: Journal of Clinical Investigation, Vol. 89, No. 5, 1992, p. 1517-1522.

Research output: Contribution to journalArticle

Santoro, M, Carlomagno, F, Hay, ID, Herrmann, MA, Grieco, M, Melillo, R, Pierotti, MA, Bongarzone, I, Porta, GD, Berger, N, Peix, JL, Paulin, C, Fabien, N, Vecchio, G, Jenkins, RB & Fusco, A 1992, 'Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype', Journal of Clinical Investigation, vol. 89, no. 5, pp. 1517-1522.
Santoro, Massimo ; Carlomagno, Francesca ; Hay, Ian D ; Herrmann, Marie A. ; Grieco, Michele ; Melillo, Rosamarina ; Pierotti, Marco A. ; Bongarzone, Italia ; Porta, Giuseppe Della ; Berger, Nicole ; Peix, Jean Louis ; Paulin, Christian ; Fabien, Nicole ; Vecchio, Giancarlo ; Jenkins, Robert Brian ; Fusco, Alfredo. / Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype. In: Journal of Clinical Investigation. 1992 ; Vol. 89, No. 5. pp. 1517-1522.
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AU - Peix, Jean Louis

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AB - We have recently reported the activation of a new oncogene in human papillary thyroid carcinomas. This oncogene, papillary thyroid carcinoma (PTC), is a novel rearranged version of the ret tyrosine-kinase protooncogene. Thyroid neoplasms include a broad spectrum of malignant tumors, ranging from well-differentiated tumors to undifferentiated anaplastic carcinomas. To determine the frequency of ret oneogene activation, we analyzed 286 cases of human thyroid tumors of diverse histologic types. We found the presence of an activated form of the ret oncogene in 33 (19%) of 177 papillary carcinomas. By contrast, none of the other 109 thyroid tumors, which included 37 follicular, 15 anaplastic, and 18 medullary carcinomas, and 34 benign lesions, showed ret activation.

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