Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype

M. Santoro, F. Carlomagno, I. D. Hay, M. A. Herrmann, M. Grieco, R. Melillo, M. A. Pierotti, I. Bongarzone, G. Della Porta, N. Berger, J. L. Peix, C. Paulin, N. Fabien, G. Vecchio, R. B. Jenkins, A. Fusco

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We have recently reported the activation of a new oncogene in human papillary thyroid carcinomas. This oncogene, papillary thyroid carcinoma (PTC), is a novel rearranged version of the ret tyrosine-kinase protooncogene. Thyroid neoplasms include a broad spectrum of malignant tumors, ranging from well-differentiated tumors to undifferentiated anaplastic carcinomas. To determine the frequency of ret oncogene activation, we analyzed 286 cases of human thyroid tumors of diverse histologic types. We found the presence of an activated form of the ret oncogene in 33 (19%) of 177 papillary carcinomas. By contrast, none of the other 109 thyroid tumors, which included 37 follicular, 15 anaplastic, and 18 medullary carcinomas, and 34 benign lesions, showed ret activation.

Original languageEnglish (US)
Pages (from-to)1517-1522
Number of pages6
JournalJournal of Clinical Investigation
Issue number5
StatePublished - Jan 1 1992



  • PTC
  • carcinoma
  • gene rearrangement
  • ret protooncogene
  • tyrosine kinase

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Santoro, M., Carlomagno, F., Hay, I. D., Herrmann, M. A., Grieco, M., Melillo, R., Pierotti, M. A., Bongarzone, I., Della Porta, G., Berger, N., Peix, J. L., Paulin, C., Fabien, N., Vecchio, G., Jenkins, R. B., & Fusco, A. (1992). Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype. Journal of Clinical Investigation, 89(5), 1517-1522.