TY - JOUR
T1 - Resting sympathetic outflow does not predict the morning blood pressure surge in hypertension
AU - Hering, Dagmara
AU - Kucharska, Wieslawa
AU - Kara, Tomas
AU - Somers, Virend K.
AU - Narkiewicz, Krzysztof
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2011/12
Y1 - 2011/12
N2 - OBJECTIVE: The blood pressure (BP) rise on awakening (morning surge) might be a predictor of hypertension-related cardiovascular complications. Previous studies suggest that the autonomic nervous system may contribute to the early morning BP increase. We tested the hypothesis that resting sympathetic outflow [assessed by direct measures of intraneural sympathetic nerve activity (SNA)] may help predict the morning BP surge in hypertension. METHODS: We measured muscle SNA (MSNA), heart rate (HR) and BP during undisturbed supine rest in 68 newly diagnosed untreated hypertensive patients (53 men and 15 women, age 40 ± 3 years, BMI 27 ± 1 kg/m, mean ± SEM). The morning BP surge was defined as the difference between the morning BP and the pre-awake BP. RESULTS: SBP averaged 143 ± 3 mmHg for daytime and 126 ± 2 mmHg for night-time. Mean HR was 81 ± 2 beats/min for daytime and 69 ± 2 beats/min for night-time. Average MSNA was 32 ± 2 bursts/min., SBP morning surge 19 ± 2 mmHg and HR morning surge 14 ± 2 beats/min. In univariate analysis, MSNA correlated with daytime SBP (r=0.28, P=0.02); night-time SBP (r=0.26, P=0.03); daytime HR (r=0.28, P=0.02); and night-time HR (r=0.26, P=0.03). Multivariate analysis, taking into consideration age, BMI and sex, revealed that MSNA was independently related to both daytime (P=0.006) and night-time HR (P=0.02), but not to ambulatory SBP. The morning surge of SBP and HR was not related to MSNA (r=0.01 and r=0.07, respectively, P=NS). CONCLUSION: In patients with essential hypertension, MSNA is related to both daytime and night-time HR, but not to the morning BP surge.
AB - OBJECTIVE: The blood pressure (BP) rise on awakening (morning surge) might be a predictor of hypertension-related cardiovascular complications. Previous studies suggest that the autonomic nervous system may contribute to the early morning BP increase. We tested the hypothesis that resting sympathetic outflow [assessed by direct measures of intraneural sympathetic nerve activity (SNA)] may help predict the morning BP surge in hypertension. METHODS: We measured muscle SNA (MSNA), heart rate (HR) and BP during undisturbed supine rest in 68 newly diagnosed untreated hypertensive patients (53 men and 15 women, age 40 ± 3 years, BMI 27 ± 1 kg/m, mean ± SEM). The morning BP surge was defined as the difference between the morning BP and the pre-awake BP. RESULTS: SBP averaged 143 ± 3 mmHg for daytime and 126 ± 2 mmHg for night-time. Mean HR was 81 ± 2 beats/min for daytime and 69 ± 2 beats/min for night-time. Average MSNA was 32 ± 2 bursts/min., SBP morning surge 19 ± 2 mmHg and HR morning surge 14 ± 2 beats/min. In univariate analysis, MSNA correlated with daytime SBP (r=0.28, P=0.02); night-time SBP (r=0.26, P=0.03); daytime HR (r=0.28, P=0.02); and night-time HR (r=0.26, P=0.03). Multivariate analysis, taking into consideration age, BMI and sex, revealed that MSNA was independently related to both daytime (P=0.006) and night-time HR (P=0.02), but not to ambulatory SBP. The morning surge of SBP and HR was not related to MSNA (r=0.01 and r=0.07, respectively, P=NS). CONCLUSION: In patients with essential hypertension, MSNA is related to both daytime and night-time HR, but not to the morning BP surge.
KW - Ambulatory blood pressure
KW - autonomic nervous system
KW - hypertension
KW - sympathetic nervous system
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U2 - 10.1097/HJH.0b013e32834c1ecd
DO - 10.1097/HJH.0b013e32834c1ecd
M3 - Article
C2 - 21986622
AN - SCOPUS:81355146546
SN - 0263-6352
VL - 29
SP - 2381
EP - 2386
JO - Journal of hypertension
JF - Journal of hypertension
IS - 12
ER -