Response to immunosuppressive therapy in patients with hereditary motor and sensory neuropathy and associated dysimmune neuromuscular disorders

Galen W. Mitchel; E. Peter Bosch; Michael N. Hart

doi:10.1159/000116154

Response to immunosuppressive therapy in patients with hereditary motor and sensory neuropathy and associated dysimmune neuromuscular disorders

Galen W. Mitchel, E. Peter Bosch, Michael N. Hart

Neurology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We encountered 2 patients with hereditary motor and sensory neuropathy (HMSN) type I who had marked weakness developing during several months superimposed on chronic peroneal muscular atrophy. Further studies disclosed a chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) in one patient and CIDP associated with polymyositis in the other. Both patients responded to prednisone and azathioprine with substantial improvement. Patients with HMSN who develop rapid progression of weakness should be evaluated for superimposed, potentially treatable dysimmune neuromuscular disorders.

Original language	English (US)
Pages (from-to)	188-196
Number of pages	9
Journal	European Neurology
Volume	27
Issue number	3
DOIs	https://doi.org/10.1159/000116154
State	Published - 1987

Keywords

Chronic inflammatory demyelinating polyradiculoneuropathy
Hereditary motor and sensory neuropathy
Immunosuppressive therapy
Polymyositis

ASJC Scopus subject areas

Neurology
Clinical Neurology

Access to Document

10.1159/000116154

Cite this

@article{626df60baa7349faa82e6932835190e3,

title = "Response to immunosuppressive therapy in patients with hereditary motor and sensory neuropathy and associated dysimmune neuromuscular disorders",

abstract = "We encountered 2 patients with hereditary motor and sensory neuropathy (HMSN) type I who had marked weakness developing during several months superimposed on chronic peroneal muscular atrophy. Further studies disclosed a chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) in one patient and CIDP associated with polymyositis in the other. Both patients responded to prednisone and azathioprine with substantial improvement. Patients with HMSN who develop rapid progression of weakness should be evaluated for superimposed, potentially treatable dysimmune neuromuscular disorders.",

keywords = "Chronic inflammatory demyelinating polyradiculoneuropathy, Hereditary motor and sensory neuropathy, Immunosuppressive therapy, Polymyositis",

author = "Mitchel, {Galen W.} and Bosch, {E. Peter} and Hart, {Michael N.}",

year = "1987",

doi = "10.1159/000116154",

language = "English (US)",

volume = "27",

pages = "188--196",

journal = "European Neurology",

issn = "0014-3022",

publisher = "S. Karger AG",

number = "3",

}

TY - JOUR

T1 - Response to immunosuppressive therapy in patients with hereditary motor and sensory neuropathy and associated dysimmune neuromuscular disorders

AU - Mitchel, Galen W.

AU - Bosch, E. Peter

AU - Hart, Michael N.

PY - 1987

Y1 - 1987

N2 - We encountered 2 patients with hereditary motor and sensory neuropathy (HMSN) type I who had marked weakness developing during several months superimposed on chronic peroneal muscular atrophy. Further studies disclosed a chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) in one patient and CIDP associated with polymyositis in the other. Both patients responded to prednisone and azathioprine with substantial improvement. Patients with HMSN who develop rapid progression of weakness should be evaluated for superimposed, potentially treatable dysimmune neuromuscular disorders.

AB - We encountered 2 patients with hereditary motor and sensory neuropathy (HMSN) type I who had marked weakness developing during several months superimposed on chronic peroneal muscular atrophy. Further studies disclosed a chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) in one patient and CIDP associated with polymyositis in the other. Both patients responded to prednisone and azathioprine with substantial improvement. Patients with HMSN who develop rapid progression of weakness should be evaluated for superimposed, potentially treatable dysimmune neuromuscular disorders.

KW - Chronic inflammatory demyelinating polyradiculoneuropathy

KW - Hereditary motor and sensory neuropathy

KW - Immunosuppressive therapy

KW - Polymyositis

UR - http://www.scopus.com/inward/record.url?scp=0023274948&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023274948&partnerID=8YFLogxK

U2 - 10.1159/000116154

DO - 10.1159/000116154

M3 - Article

C2 - 3476306

AN - SCOPUS:0023274948

SN - 0014-3022

VL - 27

SP - 188

EP - 196

JO - European Neurology

JF - European Neurology

IS - 3

ER -

Response to immunosuppressive therapy in patients with hereditary motor and sensory neuropathy and associated dysimmune neuromuscular disorders

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this