Response to immunosuppressive therapy in patients with hereditary motor and sensory neuropathy and associated dysimmune neuromuscular disorders

Galen W. Mitchel, E. Peter Bosch, Michael N. Hart

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

We encountered 2 patients with hereditary motor and sensory neuropathy (HMSN) type I who had marked weakness developing during several months superimposed on chronic peroneal muscular atrophy. Further studies disclosed a chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) in one patient and CIDP associated with polymyositis in the other. Both patients responded to prednisone and azathioprine with substantial improvement. Patients with HMSN who develop rapid progression of weakness should be evaluated for superimposed, potentially treatable dysimmune neuromuscular disorders.

Original languageEnglish (US)
Pages (from-to)188-196
Number of pages9
JournalEuropean Neurology
Volume27
Issue number3
DOIs
StatePublished - Jan 1 1987

Keywords

  • Chronic inflammatory demyelinating polyradiculoneuropathy
  • Hereditary motor and sensory neuropathy
  • Immunosuppressive therapy
  • Polymyositis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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