TY - JOUR
T1 - Response of the Retinal Pigment Epithelium to Selective Photocoagulation
AU - Roider, Johann
AU - Michaud, Norman A.
AU - Flotte, Thomas J.
AU - Birngruber, Reginald
PY - 1992/12
Y1 - 1992/12
N2 - Multiple short argon laser pulses can coagulate the retinal pigment epithelium selectively, while sparing the adjacent neural retina and choroid; in contrast, continuous-wave laser irradiation typically damages the neural retina and choroid. The healing response to selective photocoagulation of the retinal pigment epithelium was studied in rabbits during a period of 4 weeks. The lesions were never visible ophthalmoscopically. During the healing period, the epithelium was reformed by a single sheet of hypertrophic retinal pigment epithelial cells. In contrast to continuous-wave photocoagulation, only minimal inflammatory response was found. Retinal pigment epithelial cells showed clear signs of viability, eg, phagocytized outer segments. The local edema in the photoreceptor layer and subretinal space found in the early stage disappeared when the blood-retinal barrier was reestablished. The choriocapillaris remained unaffected. No subsequent damage to the photoreceptors was found. This type of photocoagulation may be useful for retinal pigment epithelium—related diseases, eg, diffuse diabetic macular edema.
AB - Multiple short argon laser pulses can coagulate the retinal pigment epithelium selectively, while sparing the adjacent neural retina and choroid; in contrast, continuous-wave laser irradiation typically damages the neural retina and choroid. The healing response to selective photocoagulation of the retinal pigment epithelium was studied in rabbits during a period of 4 weeks. The lesions were never visible ophthalmoscopically. During the healing period, the epithelium was reformed by a single sheet of hypertrophic retinal pigment epithelial cells. In contrast to continuous-wave photocoagulation, only minimal inflammatory response was found. Retinal pigment epithelial cells showed clear signs of viability, eg, phagocytized outer segments. The local edema in the photoreceptor layer and subretinal space found in the early stage disappeared when the blood-retinal barrier was reestablished. The choriocapillaris remained unaffected. No subsequent damage to the photoreceptors was found. This type of photocoagulation may be useful for retinal pigment epithelium—related diseases, eg, diffuse diabetic macular edema.
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U2 - 10.1001/archopht.1992.01080240126045
DO - 10.1001/archopht.1992.01080240126045
M3 - Article
C2 - 1463423
AN - SCOPUS:0026476696
SN - 0003-9950
VL - 110
SP - 1786
EP - 1792
JO - Archives of ophthalmology
JF - Archives of ophthalmology
IS - 12
ER -