Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy

Hongxiang Liu, Agnes Ruskon-Fourmestraux, Anne Lavergne-Slove, Hongtao Ye, Thierry Molina, Yoram Bouhnik, Rifat A. Hamoudi, Tim C. Diss, Ahmet Dogan, Francis Megraud, Jean Claude Rambaud, Ming Qing Du, Peter G. Isaacson

Research output: Contribution to journalArticle

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Abstract

20-30% of gastric mucosa-associated lymphoid tissue (MALT) lymphoma associated with Helicobacter pylori do not regress after antibiotic therapy. Regression can be assessed only by extended follow-up. To assess whether t(11;18, q21;q21), which results in a chimeric transcript between the API2 and MLT genes, predicts lymphoma resistance to antibiotic therapy, we screened for the fusion transcript with RT-PCR in ten responsive and 12 non-responsive gastric MALT lymphomas. The API2-MLT transcript was detected in nine (75%) of 12 patients non-responsive to antibiotic therapy but not in responsive patients. Most H pylori-associated gastric MALT lymphomas that do not respond to antibiotic therapy are associated with t(11;18, q21;q21).

Original languageEnglish (US)
Pages (from-to)39-40
Number of pages2
JournalLancet
Volume357
Issue number9249
DOIs
StatePublished - Jan 6 2001
Externally publishedYes

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Marginal Zone B-Cell Lymphoma
Gastric Mucosa
Helicobacter pylori
Anti-Bacterial Agents
Pylorus
Therapeutics
Microbial Drug Resistance
Lymphoma
Polymerase Chain Reaction
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Liu, H., Ruskon-Fourmestraux, A., Lavergne-Slove, A., Ye, H., Molina, T., Bouhnik, Y., ... Isaacson, P. G. (2001). Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy. Lancet, 357(9249), 39-40. https://doi.org/10.1016/S0140-6736(00)03571-6

Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy. / Liu, Hongxiang; Ruskon-Fourmestraux, Agnes; Lavergne-Slove, Anne; Ye, Hongtao; Molina, Thierry; Bouhnik, Yoram; Hamoudi, Rifat A.; Diss, Tim C.; Dogan, Ahmet; Megraud, Francis; Rambaud, Jean Claude; Du, Ming Qing; Isaacson, Peter G.

In: Lancet, Vol. 357, No. 9249, 06.01.2001, p. 39-40.

Research output: Contribution to journalArticle

Liu, H, Ruskon-Fourmestraux, A, Lavergne-Slove, A, Ye, H, Molina, T, Bouhnik, Y, Hamoudi, RA, Diss, TC, Dogan, A, Megraud, F, Rambaud, JC, Du, MQ & Isaacson, PG 2001, 'Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy', Lancet, vol. 357, no. 9249, pp. 39-40. https://doi.org/10.1016/S0140-6736(00)03571-6
Liu, Hongxiang ; Ruskon-Fourmestraux, Agnes ; Lavergne-Slove, Anne ; Ye, Hongtao ; Molina, Thierry ; Bouhnik, Yoram ; Hamoudi, Rifat A. ; Diss, Tim C. ; Dogan, Ahmet ; Megraud, Francis ; Rambaud, Jean Claude ; Du, Ming Qing ; Isaacson, Peter G. / Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy. In: Lancet. 2001 ; Vol. 357, No. 9249. pp. 39-40.
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