Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy

Hongxiang Liu, Agnes Ruskon-Fourmestraux, Anne Lavergne-Slove, Hongtao Ye, Thierry Molina, Yoram Bouhnik, Rifat A. Hamoudi, Tim C. Diss, Ahmet Dogan, Francis Megraud, Jean Claude Rambaud, Ming Qing Du, Peter G. Isaacson

Research output: Contribution to journalArticlepeer-review

374 Scopus citations

Abstract

20-30% of gastric mucosa-associated lymphoid tissue (MALT) lymphoma associated with Helicobacter pylori do not regress after antibiotic therapy. Regression can be assessed only by extended follow-up. To assess whether t(11;18, q21;q21), which results in a chimeric transcript between the API2 and MLT genes, predicts lymphoma resistance to antibiotic therapy, we screened for the fusion transcript with RT-PCR in ten responsive and 12 non-responsive gastric MALT lymphomas. The API2-MLT transcript was detected in nine (75%) of 12 patients non-responsive to antibiotic therapy but not in responsive patients. Most H pylori-associated gastric MALT lymphomas that do not respond to antibiotic therapy are associated with t(11;18, q21;q21).

Original languageEnglish (US)
Pages (from-to)39-40
Number of pages2
JournalLancet
Volume357
Issue number9249
DOIs
StatePublished - Jan 6 2001

ASJC Scopus subject areas

  • Medicine(all)

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