Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy

Hongxiang Liu; Agnes Ruskon-Fourmestraux; Anne Lavergne-Slove; Hongtao Ye; Thierry Molina; Yoram Bouhnik; Rifat A. Hamoudi; Tim C. Diss; Ahmet Dogan; Francis Megraud; Jean Claude Rambaud; Ming Qing Du; Peter G. Isaacson

doi:10.1016/S0140-6736(00)03571-6

Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy

Hongxiang Liu, Agnes Ruskon-Fourmestraux, Anne Lavergne-Slove, Hongtao Ye, Thierry Molina, Yoram Bouhnik, Rifat A. Hamoudi, Tim C. Diss, Ahmet Dogan, Francis Megraud, Jean Claude Rambaud, Ming Qing Du, Peter G. Isaacson

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

374 Scopus citations

Abstract

20-30% of gastric mucosa-associated lymphoid tissue (MALT) lymphoma associated with Helicobacter pylori do not regress after antibiotic therapy. Regression can be assessed only by extended follow-up. To assess whether t(11;18, q21;q21), which results in a chimeric transcript between the API2 and MLT genes, predicts lymphoma resistance to antibiotic therapy, we screened for the fusion transcript with RT-PCR in ten responsive and 12 non-responsive gastric MALT lymphomas. The API2-MLT transcript was detected in nine (75%) of 12 patients non-responsive to antibiotic therapy but not in responsive patients. Most H pylori-associated gastric MALT lymphomas that do not respond to antibiotic therapy are associated with t(11;18, q21;q21).

Original language	English (US)
Pages (from-to)	39-40
Number of pages	2
Journal	Lancet
Volume	357
Issue number	9249
DOIs	https://doi.org/10.1016/S0140-6736(00)03571-6
State	Published - Jan 6 2001

ASJC Scopus subject areas

General Medicine

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Liu, H., Ruskon-Fourmestraux, A., Lavergne-Slove, A., Ye, H., Molina, T., Bouhnik, Y., Hamoudi, R. A., Diss, T. C., Dogan, A., Megraud, F., Rambaud, J. C., Du, M. Q., & Isaacson, P. G. (2001). Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy. Lancet, 357(9249), 39-40. https://doi.org/10.1016/S0140-6736(00)03571-6

Liu, H, Ruskon-Fourmestraux, A, Lavergne-Slove, A, Ye, H, Molina, T, Bouhnik, Y, Hamoudi, RA, Diss, TC, Dogan, A, Megraud, F, Rambaud, JC, Du, MQ & Isaacson, PG 2001, 'Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy', Lancet, vol. 357, no. 9249, pp. 39-40. https://doi.org/10.1016/S0140-6736(00)03571-6

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title = "Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy",

abstract = "20-30% of gastric mucosa-associated lymphoid tissue (MALT) lymphoma associated with Helicobacter pylori do not regress after antibiotic therapy. Regression can be assessed only by extended follow-up. To assess whether t(11;18, q21;q21), which results in a chimeric transcript between the API2 and MLT genes, predicts lymphoma resistance to antibiotic therapy, we screened for the fusion transcript with RT-PCR in ten responsive and 12 non-responsive gastric MALT lymphomas. The API2-MLT transcript was detected in nine (75%) of 12 patients non-responsive to antibiotic therapy but not in responsive patients. Most H pylori-associated gastric MALT lymphomas that do not respond to antibiotic therapy are associated with t(11;18, q21;q21).",

author = "Hongxiang Liu and Agnes Ruskon-Fourmestraux and Anne Lavergne-Slove and Hongtao Ye and Thierry Molina and Yoram Bouhnik and Hamoudi, {Rifat A.} and Diss, {Tim C.} and Ahmet Dogan and Francis Megraud and Rambaud, {Jean Claude} and Du, {Ming Qing} and Isaacson, {Peter G.}",

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AU - Liu, Hongxiang

AU - Ruskon-Fourmestraux, Agnes

AU - Lavergne-Slove, Anne

AU - Ye, Hongtao

AU - Molina, Thierry

AU - Bouhnik, Yoram

AU - Hamoudi, Rifat A.

AU - Diss, Tim C.

AU - Dogan, Ahmet

AU - Megraud, Francis

AU - Rambaud, Jean Claude

AU - Du, Ming Qing

AU - Isaacson, Peter G.

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N2 - 20-30% of gastric mucosa-associated lymphoid tissue (MALT) lymphoma associated with Helicobacter pylori do not regress after antibiotic therapy. Regression can be assessed only by extended follow-up. To assess whether t(11;18, q21;q21), which results in a chimeric transcript between the API2 and MLT genes, predicts lymphoma resistance to antibiotic therapy, we screened for the fusion transcript with RT-PCR in ten responsive and 12 non-responsive gastric MALT lymphomas. The API2-MLT transcript was detected in nine (75%) of 12 patients non-responsive to antibiotic therapy but not in responsive patients. Most H pylori-associated gastric MALT lymphomas that do not respond to antibiotic therapy are associated with t(11;18, q21;q21).

AB - 20-30% of gastric mucosa-associated lymphoid tissue (MALT) lymphoma associated with Helicobacter pylori do not regress after antibiotic therapy. Regression can be assessed only by extended follow-up. To assess whether t(11;18, q21;q21), which results in a chimeric transcript between the API2 and MLT genes, predicts lymphoma resistance to antibiotic therapy, we screened for the fusion transcript with RT-PCR in ten responsive and 12 non-responsive gastric MALT lymphomas. The API2-MLT transcript was detected in nine (75%) of 12 patients non-responsive to antibiotic therapy but not in responsive patients. Most H pylori-associated gastric MALT lymphomas that do not respond to antibiotic therapy are associated with t(11;18, q21;q21).

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Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy

Abstract

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